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Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO)

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Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO). / Mikolajczyk, Rafael; Diexer, Sophie; Klee, Bianca; Pfrommer, Laura; Purschke, Oliver; Fricke, Julia; Ahnert, Peter; Gabrysch, Sabine; Gottschick, Cornelia; Bohn, Barbara; Brenner, Hermann; Buck, Christoph; Castell, Stefanie; Gastell, Sylvia; Greiser, Karin Halina; Harth, Volker; Heise, Jana-Kristin; Holleczek, Bernd; Kaaks, Rudolf; Keil, Thomas; Krist, Lilian; Leitzmann, Michael; Lieb, Wolfgang; Meinke-Franze, Claudia; Michels, Karin B; Velásquez, Ilais Moreno; Obi, Nadia; Panreck, Leo; Peters, Annette; Pischon, Tobias; Schikowski, Tamara; Schmidt, Börge; Standl, Marie; Stang, Andreas; Völzke, Henry; Weber, Andrea; Zeeb, Hajo; Karch, André.

in: J INFECTION, Jahrgang 89, Nr. 2, 08.2024, S. 106206.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mikolajczyk, R, Diexer, S, Klee, B, Pfrommer, L, Purschke, O, Fricke, J, Ahnert, P, Gabrysch, S, Gottschick, C, Bohn, B, Brenner, H, Buck, C, Castell, S, Gastell, S, Greiser, KH, Harth, V, Heise, J-K, Holleczek, B, Kaaks, R, Keil, T, Krist, L, Leitzmann, M, Lieb, W, Meinke-Franze, C, Michels, KB, Velásquez, IM, Obi, N, Panreck, L, Peters, A, Pischon, T, Schikowski, T, Schmidt, B, Standl, M, Stang, A, Völzke, H, Weber, A, Zeeb, H & Karch, A 2024, 'Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO)', J INFECTION, Jg. 89, Nr. 2, S. 106206. https://doi.org/10.1016/j.jinf.2024.106206

APA

Mikolajczyk, R., Diexer, S., Klee, B., Pfrommer, L., Purschke, O., Fricke, J., Ahnert, P., Gabrysch, S., Gottschick, C., Bohn, B., Brenner, H., Buck, C., Castell, S., Gastell, S., Greiser, K. H., Harth, V., Heise, J-K., Holleczek, B., Kaaks, R., ... Karch, A. (2024). Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO). J INFECTION, 89(2), 106206. https://doi.org/10.1016/j.jinf.2024.106206

Vancouver

Mikolajczyk R, Diexer S, Klee B, Pfrommer L, Purschke O, Fricke J et al. Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO). J INFECTION. 2024 Aug;89(2):106206. https://doi.org/10.1016/j.jinf.2024.106206

Bibtex

@article{465d9e3201624db9a3e9235ef2960b42,
title = "Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO)",
abstract = "OBJECTIVES: The risk of Post-COVID-19 condition (PCC) under hybrid immunity remains unclear.METHODS: Using data from the German National Cohort (NAKO Gesundheitsstudie), we investigated risk factors for self-reported post-infection symptoms (any PCC is defined as having at least one symptom, and high symptom burden PCC as having nine or more symptoms).RESULTS: Sixty percent of 109,707 participants reported at least one previous SARS-CoV-2 infection; 35% reported having had any symptoms 4-12 months after infection; among them 23% reported nine or more symptoms. Individuals, who did not develop PCC after their first infection, had a strongly reduced risk for PCC after their second infection (50%) and a temporary risk reduction, which waned over 9 months after the preceding infection. The risk of developing PCC strongly depended on the virus variant. Within variants, there was no effect of the number of preceding vaccinations, apart from a strong protection by the fourth vaccination compared to three vaccinations for the Omicron variant (odds ratio = 0.52; 95% confidence interval 0.45-0.61).CONCLUSIONS: Previous infections without PCC and a fourth vaccination were associated with a lower risk of PCC after a new infection, indicating diminished risk under hybrid immunity. The two components of risk reduction after a preceding infection suggest different immunological mechanisms.",
author = "Rafael Mikolajczyk and Sophie Diexer and Bianca Klee and Laura Pfrommer and Oliver Purschke and Julia Fricke and Peter Ahnert and Sabine Gabrysch and Cornelia Gottschick and Barbara Bohn and Hermann Brenner and Christoph Buck and Stefanie Castell and Sylvia Gastell and Greiser, {Karin Halina} and Volker Harth and Jana-Kristin Heise and Bernd Holleczek and Rudolf Kaaks and Thomas Keil and Lilian Krist and Michael Leitzmann and Wolfgang Lieb and Claudia Meinke-Franze and Michels, {Karin B} and Vel{\'a}squez, {Ilais Moreno} and Nadia Obi and Leo Panreck and Annette Peters and Tobias Pischon and Tamara Schikowski and B{\"o}rge Schmidt and Marie Standl and Andreas Stang and Henry V{\"o}lzke and Andrea Weber and Hajo Zeeb and Andr{\'e} Karch",
note = "Copyright {\textcopyright} 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.",
year = "2024",
month = aug,
doi = "10.1016/j.jinf.2024.106206",
language = "English",
volume = "89",
pages = "106206",
journal = "J INFECTION",
issn = "0163-4453",
publisher = "W.B. Saunders Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO)

AU - Mikolajczyk, Rafael

AU - Diexer, Sophie

AU - Klee, Bianca

AU - Pfrommer, Laura

AU - Purschke, Oliver

AU - Fricke, Julia

AU - Ahnert, Peter

AU - Gabrysch, Sabine

AU - Gottschick, Cornelia

AU - Bohn, Barbara

AU - Brenner, Hermann

AU - Buck, Christoph

AU - Castell, Stefanie

AU - Gastell, Sylvia

AU - Greiser, Karin Halina

AU - Harth, Volker

AU - Heise, Jana-Kristin

AU - Holleczek, Bernd

AU - Kaaks, Rudolf

AU - Keil, Thomas

AU - Krist, Lilian

AU - Leitzmann, Michael

AU - Lieb, Wolfgang

AU - Meinke-Franze, Claudia

AU - Michels, Karin B

AU - Velásquez, Ilais Moreno

AU - Obi, Nadia

AU - Panreck, Leo

AU - Peters, Annette

AU - Pischon, Tobias

AU - Schikowski, Tamara

AU - Schmidt, Börge

AU - Standl, Marie

AU - Stang, Andreas

AU - Völzke, Henry

AU - Weber, Andrea

AU - Zeeb, Hajo

AU - Karch, André

N1 - Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.

PY - 2024/8

Y1 - 2024/8

N2 - OBJECTIVES: The risk of Post-COVID-19 condition (PCC) under hybrid immunity remains unclear.METHODS: Using data from the German National Cohort (NAKO Gesundheitsstudie), we investigated risk factors for self-reported post-infection symptoms (any PCC is defined as having at least one symptom, and high symptom burden PCC as having nine or more symptoms).RESULTS: Sixty percent of 109,707 participants reported at least one previous SARS-CoV-2 infection; 35% reported having had any symptoms 4-12 months after infection; among them 23% reported nine or more symptoms. Individuals, who did not develop PCC after their first infection, had a strongly reduced risk for PCC after their second infection (50%) and a temporary risk reduction, which waned over 9 months after the preceding infection. The risk of developing PCC strongly depended on the virus variant. Within variants, there was no effect of the number of preceding vaccinations, apart from a strong protection by the fourth vaccination compared to three vaccinations for the Omicron variant (odds ratio = 0.52; 95% confidence interval 0.45-0.61).CONCLUSIONS: Previous infections without PCC and a fourth vaccination were associated with a lower risk of PCC after a new infection, indicating diminished risk under hybrid immunity. The two components of risk reduction after a preceding infection suggest different immunological mechanisms.

AB - OBJECTIVES: The risk of Post-COVID-19 condition (PCC) under hybrid immunity remains unclear.METHODS: Using data from the German National Cohort (NAKO Gesundheitsstudie), we investigated risk factors for self-reported post-infection symptoms (any PCC is defined as having at least one symptom, and high symptom burden PCC as having nine or more symptoms).RESULTS: Sixty percent of 109,707 participants reported at least one previous SARS-CoV-2 infection; 35% reported having had any symptoms 4-12 months after infection; among them 23% reported nine or more symptoms. Individuals, who did not develop PCC after their first infection, had a strongly reduced risk for PCC after their second infection (50%) and a temporary risk reduction, which waned over 9 months after the preceding infection. The risk of developing PCC strongly depended on the virus variant. Within variants, there was no effect of the number of preceding vaccinations, apart from a strong protection by the fourth vaccination compared to three vaccinations for the Omicron variant (odds ratio = 0.52; 95% confidence interval 0.45-0.61).CONCLUSIONS: Previous infections without PCC and a fourth vaccination were associated with a lower risk of PCC after a new infection, indicating diminished risk under hybrid immunity. The two components of risk reduction after a preceding infection suggest different immunological mechanisms.

U2 - 10.1016/j.jinf.2024.106206

DO - 10.1016/j.jinf.2024.106206

M3 - SCORING: Journal article

C2 - 38897239

VL - 89

SP - 106206

JO - J INFECTION

JF - J INFECTION

SN - 0163-4453

IS - 2

ER -