Levosimendan improves diastolic and systolic function in failing human myocardium.
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Levosimendan improves diastolic and systolic function in failing human myocardium. / Janssen, P M; Datz, N; Zeitz, Oliver; Hasenfuss, G.
In: EUR J PHARMACOL, Vol. 404, No. 1-2, 1-2, 2000, p. 191-199.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Levosimendan improves diastolic and systolic function in failing human myocardium.
AU - Janssen, P M
AU - Datz, N
AU - Zeitz, Oliver
AU - Hasenfuss, G
PY - 2000
Y1 - 2000
N2 - Ca(2+)-sensitizers increase myocardial contractility, but may worsen diastolic dysfunction. Levosimendan, through its unique troponin-C interaction, may preserve diastolic function. We investigated the effects of levosimendan (10(-7)-10(-5) M) on diastolic and systolic function in multicellular cardiac muscle preparations from end-stage failing human hearts (1 and 2.5 Hz, 37 degrees C, 1.25 mM [Ca(2+)], pH 7.4). Levosimendan improved systolic function: at 1 Hz, developed force (F(dev)) increased from 13.84+/-3.27 to 16.40+/-3.57 (10(-7) M, P
AB - Ca(2+)-sensitizers increase myocardial contractility, but may worsen diastolic dysfunction. Levosimendan, through its unique troponin-C interaction, may preserve diastolic function. We investigated the effects of levosimendan (10(-7)-10(-5) M) on diastolic and systolic function in multicellular cardiac muscle preparations from end-stage failing human hearts (1 and 2.5 Hz, 37 degrees C, 1.25 mM [Ca(2+)], pH 7.4). Levosimendan improved systolic function: at 1 Hz, developed force (F(dev)) increased from 13.84+/-3.27 to 16.40+/-3.57 (10(-7) M, P
M3 - SCORING: Zeitschriftenaufsatz
VL - 404
SP - 191
EP - 199
JO - EUR J PHARMACOL
JF - EUR J PHARMACOL
SN - 0014-2999
IS - 1-2
M1 - 1-2
ER -