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Levosimendan improves diastolic and systolic function in failing human myocardium.

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Levosimendan improves diastolic and systolic function in failing human myocardium. / Janssen, P M; Datz, N; Zeitz, Oliver; Hasenfuss, G.

in: EUR J PHARMACOL, Jahrgang 404, Nr. 1-2, 1-2, 2000, S. 191-199.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Janssen, PM, Datz, N, Zeitz, O & Hasenfuss, G 2000, 'Levosimendan improves diastolic and systolic function in failing human myocardium.', EUR J PHARMACOL, Jg. 404, Nr. 1-2, 1-2, S. 191-199. <http://www.ncbi.nlm.nih.gov/pubmed/10980279?dopt=Citation>

APA

Janssen, P. M., Datz, N., Zeitz, O., & Hasenfuss, G. (2000). Levosimendan improves diastolic and systolic function in failing human myocardium. EUR J PHARMACOL, 404(1-2), 191-199. [1-2]. http://www.ncbi.nlm.nih.gov/pubmed/10980279?dopt=Citation

Vancouver

Janssen PM, Datz N, Zeitz O, Hasenfuss G. Levosimendan improves diastolic and systolic function in failing human myocardium. EUR J PHARMACOL. 2000;404(1-2):191-199. 1-2.

Bibtex

@article{017583cdd60041bd9d078ca316c8822d,
title = "Levosimendan improves diastolic and systolic function in failing human myocardium.",
abstract = "Ca(2+)-sensitizers increase myocardial contractility, but may worsen diastolic dysfunction. Levosimendan, through its unique troponin-C interaction, may preserve diastolic function. We investigated the effects of levosimendan (10(-7)-10(-5) M) on diastolic and systolic function in multicellular cardiac muscle preparations from end-stage failing human hearts (1 and 2.5 Hz, 37 degrees C, 1.25 mM [Ca(2+)], pH 7.4). Levosimendan improved systolic function: at 1 Hz, developed force (F(dev)) increased from 13.84+/-3.27 to 16.40+/-3.57 (10(-7) M, P",
author = "Janssen, {P M} and N Datz and Oliver Zeitz and G Hasenfuss",
year = "2000",
language = "Deutsch",
volume = "404",
pages = "191--199",
journal = "EUR J PHARMACOL",
issn = "0014-2999",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Levosimendan improves diastolic and systolic function in failing human myocardium.

AU - Janssen, P M

AU - Datz, N

AU - Zeitz, Oliver

AU - Hasenfuss, G

PY - 2000

Y1 - 2000

N2 - Ca(2+)-sensitizers increase myocardial contractility, but may worsen diastolic dysfunction. Levosimendan, through its unique troponin-C interaction, may preserve diastolic function. We investigated the effects of levosimendan (10(-7)-10(-5) M) on diastolic and systolic function in multicellular cardiac muscle preparations from end-stage failing human hearts (1 and 2.5 Hz, 37 degrees C, 1.25 mM [Ca(2+)], pH 7.4). Levosimendan improved systolic function: at 1 Hz, developed force (F(dev)) increased from 13.84+/-3.27 to 16.40+/-3.57 (10(-7) M, P

AB - Ca(2+)-sensitizers increase myocardial contractility, but may worsen diastolic dysfunction. Levosimendan, through its unique troponin-C interaction, may preserve diastolic function. We investigated the effects of levosimendan (10(-7)-10(-5) M) on diastolic and systolic function in multicellular cardiac muscle preparations from end-stage failing human hearts (1 and 2.5 Hz, 37 degrees C, 1.25 mM [Ca(2+)], pH 7.4). Levosimendan improved systolic function: at 1 Hz, developed force (F(dev)) increased from 13.84+/-3.27 to 16.40+/-3.57 (10(-7) M, P

M3 - SCORING: Zeitschriftenaufsatz

VL - 404

SP - 191

EP - 199

JO - EUR J PHARMACOL

JF - EUR J PHARMACOL

SN - 0014-2999

IS - 1-2

M1 - 1-2

ER -