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Levodopa faster and better word learning in normal humans

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Levodopa faster and better word learning in normal humans. / Knecht, Stefan; Breitenstein, Caterina; Bushuven, Stefan; Wailke, Stefanie; Kamping, Sandra; Flöel, Agnes; Zwitserlood, Pienie; Ringelstein, E Bernd.

In: ANN NEUROL, Vol. 56, No. 1, 07.2004, p. 20-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Knecht, S, Breitenstein, C, Bushuven, S, Wailke, S, Kamping, S, Flöel, A, Zwitserlood, P & Ringelstein, EB 2004, 'Levodopa faster and better word learning in normal humans', ANN NEUROL, vol. 56, no. 1, pp. 20-6. https://doi.org/10.1002/ana.20125

APA

Knecht, S., Breitenstein, C., Bushuven, S., Wailke, S., Kamping, S., Flöel, A., Zwitserlood, P., & Ringelstein, E. B. (2004). Levodopa faster and better word learning in normal humans. ANN NEUROL, 56(1), 20-6. https://doi.org/10.1002/ana.20125

Vancouver

Knecht S, Breitenstein C, Bushuven S, Wailke S, Kamping S, Flöel A et al. Levodopa faster and better word learning in normal humans. ANN NEUROL. 2004 Jul;56(1):20-6. https://doi.org/10.1002/ana.20125

Bibtex

@article{a3378ce0e6d84e689986b89b877f8301,
title = "Levodopa faster and better word learning in normal humans",
abstract = "Dopamine is a potent modulator of learning and has been implicated in the encoding of stimulus salience. Repetition, however, as required for the acquisition and reacquisition of sensorimotor or cognitive skills (e.g., in aphasia therapy), decreases salience. We here tested whether increasing brain levels of dopamine during repetitive training improves learning success. Forty healthy humans took 100mg of the dopamine precursor levodopa or placebo daily for 5 days in a randomized double-blind and parallel-group design. Ninety minutes later on each day, subjects were trained on an artificial vocabulary using a high-frequency repetitive approach. Levodopa significantly enhanced the speed, overall success, and long-term retention of novel word learning in a dose-dependent manner. These findings indicate new ways to potentiate learning in a variety of domains if conventional training alone fails.",
keywords = "Adult, Dopamine Agents, Double-Blind Method, Humans, Learning, Levodopa, Male, Mental Recall, Placebos, Psychomotor Performance, Vocabulary",
author = "Stefan Knecht and Caterina Breitenstein and Stefan Bushuven and Stefanie Wailke and Sandra Kamping and Agnes Fl{\"o}el and Pienie Zwitserlood and Ringelstein, {E Bernd}",
year = "2004",
month = jul,
doi = "10.1002/ana.20125",
language = "English",
volume = "56",
pages = "20--6",
journal = "ANN NEUROL",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Levodopa faster and better word learning in normal humans

AU - Knecht, Stefan

AU - Breitenstein, Caterina

AU - Bushuven, Stefan

AU - Wailke, Stefanie

AU - Kamping, Sandra

AU - Flöel, Agnes

AU - Zwitserlood, Pienie

AU - Ringelstein, E Bernd

PY - 2004/7

Y1 - 2004/7

N2 - Dopamine is a potent modulator of learning and has been implicated in the encoding of stimulus salience. Repetition, however, as required for the acquisition and reacquisition of sensorimotor or cognitive skills (e.g., in aphasia therapy), decreases salience. We here tested whether increasing brain levels of dopamine during repetitive training improves learning success. Forty healthy humans took 100mg of the dopamine precursor levodopa or placebo daily for 5 days in a randomized double-blind and parallel-group design. Ninety minutes later on each day, subjects were trained on an artificial vocabulary using a high-frequency repetitive approach. Levodopa significantly enhanced the speed, overall success, and long-term retention of novel word learning in a dose-dependent manner. These findings indicate new ways to potentiate learning in a variety of domains if conventional training alone fails.

AB - Dopamine is a potent modulator of learning and has been implicated in the encoding of stimulus salience. Repetition, however, as required for the acquisition and reacquisition of sensorimotor or cognitive skills (e.g., in aphasia therapy), decreases salience. We here tested whether increasing brain levels of dopamine during repetitive training improves learning success. Forty healthy humans took 100mg of the dopamine precursor levodopa or placebo daily for 5 days in a randomized double-blind and parallel-group design. Ninety minutes later on each day, subjects were trained on an artificial vocabulary using a high-frequency repetitive approach. Levodopa significantly enhanced the speed, overall success, and long-term retention of novel word learning in a dose-dependent manner. These findings indicate new ways to potentiate learning in a variety of domains if conventional training alone fails.

KW - Adult

KW - Dopamine Agents

KW - Double-Blind Method

KW - Humans

KW - Learning

KW - Levodopa

KW - Male

KW - Mental Recall

KW - Placebos

KW - Psychomotor Performance

KW - Vocabulary

U2 - 10.1002/ana.20125

DO - 10.1002/ana.20125

M3 - SCORING: Journal article

C2 - 15236398

VL - 56

SP - 20

EP - 26

JO - ANN NEUROL

JF - ANN NEUROL

SN - 0364-5134

IS - 1

ER -