Levodopa faster and better word learning in normal humans
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Levodopa faster and better word learning in normal humans. / Knecht, Stefan; Breitenstein, Caterina; Bushuven, Stefan; Wailke, Stefanie; Kamping, Sandra; Flöel, Agnes; Zwitserlood, Pienie; Ringelstein, E Bernd.
in: ANN NEUROL, Jahrgang 56, Nr. 1, 07.2004, S. 20-6.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Levodopa faster and better word learning in normal humans
AU - Knecht, Stefan
AU - Breitenstein, Caterina
AU - Bushuven, Stefan
AU - Wailke, Stefanie
AU - Kamping, Sandra
AU - Flöel, Agnes
AU - Zwitserlood, Pienie
AU - Ringelstein, E Bernd
PY - 2004/7
Y1 - 2004/7
N2 - Dopamine is a potent modulator of learning and has been implicated in the encoding of stimulus salience. Repetition, however, as required for the acquisition and reacquisition of sensorimotor or cognitive skills (e.g., in aphasia therapy), decreases salience. We here tested whether increasing brain levels of dopamine during repetitive training improves learning success. Forty healthy humans took 100mg of the dopamine precursor levodopa or placebo daily for 5 days in a randomized double-blind and parallel-group design. Ninety minutes later on each day, subjects were trained on an artificial vocabulary using a high-frequency repetitive approach. Levodopa significantly enhanced the speed, overall success, and long-term retention of novel word learning in a dose-dependent manner. These findings indicate new ways to potentiate learning in a variety of domains if conventional training alone fails.
AB - Dopamine is a potent modulator of learning and has been implicated in the encoding of stimulus salience. Repetition, however, as required for the acquisition and reacquisition of sensorimotor or cognitive skills (e.g., in aphasia therapy), decreases salience. We here tested whether increasing brain levels of dopamine during repetitive training improves learning success. Forty healthy humans took 100mg of the dopamine precursor levodopa or placebo daily for 5 days in a randomized double-blind and parallel-group design. Ninety minutes later on each day, subjects were trained on an artificial vocabulary using a high-frequency repetitive approach. Levodopa significantly enhanced the speed, overall success, and long-term retention of novel word learning in a dose-dependent manner. These findings indicate new ways to potentiate learning in a variety of domains if conventional training alone fails.
KW - Adult
KW - Dopamine Agents
KW - Double-Blind Method
KW - Humans
KW - Learning
KW - Levodopa
KW - Male
KW - Mental Recall
KW - Placebos
KW - Psychomotor Performance
KW - Vocabulary
U2 - 10.1002/ana.20125
DO - 10.1002/ana.20125
M3 - SCORING: Journal article
C2 - 15236398
VL - 56
SP - 20
EP - 26
JO - ANN NEUROL
JF - ANN NEUROL
SN - 0364-5134
IS - 1
ER -