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Levels of haemolysis have no effect on femoral vein post-mortem tryptase levels

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Levels of haemolysis have no effect on femoral vein post-mortem tryptase levels. / Garland, Jack; Ondruschka, Benjamin; Da Broi, Ugo; Palmiere, Cristian; Glenn, Charley; Morrow, Paul; Kesha, Kilak; Stables, Simon; Tse, Rexson.

In: MED SCI LAW, Vol. 61, No. 4, 2021, p. 250-255.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Garland, J, Ondruschka, B, Da Broi, U, Palmiere, C, Glenn, C, Morrow, P, Kesha, K, Stables, S & Tse, R 2021, 'Levels of haemolysis have no effect on femoral vein post-mortem tryptase levels', MED SCI LAW, vol. 61, no. 4, pp. 250-255. https://doi.org/doi.org/10.1177/0025802421998851

APA

Garland, J., Ondruschka, B., Da Broi, U., Palmiere, C., Glenn, C., Morrow, P., Kesha, K., Stables, S., & Tse, R. (2021). Levels of haemolysis have no effect on femoral vein post-mortem tryptase levels. MED SCI LAW, 61(4), 250-255. https://doi.org/doi.org/10.1177/0025802421998851

Vancouver

Garland J, Ondruschka B, Da Broi U, Palmiere C, Glenn C, Morrow P et al. Levels of haemolysis have no effect on femoral vein post-mortem tryptase levels. MED SCI LAW. 2021;61(4):250-255. https://doi.org/doi.org/10.1177/0025802421998851

Bibtex

@article{791cac1ca8a8418988b633730a5d4261,
title = "Levels of haemolysis have no effect on femoral vein post-mortem tryptase levels",
abstract = "Haemolysis is reported to be an artefact that may alter post-mortem tryptase levels. However, previous studies did not sample peripheral blood using newly standardised methods. Recent studies have shown that some previously recognised peri- and post-mortem confounders can be muted by careful sample collection with first clamping and then sampling the femoral vein. This prospective study investigated the relationship between the degree of haemolysis of the blood samples and femoral vein post-mortem tryptase levels when sampled using this recommended method. Seventy consecutive post-mortem tryptase levels in non-anaphylactic deaths were compared to the degree of haemolysis of these samples, and results showed no significant correlation between them. The mean post-mortem tryptase level was 9.5 μg/L. This study demonstrated that the effects of haemolysis on femoral vein post-mortem tryptase was negligible when the blood was sampled using the recommended sampling method. Future studies on post-mortem tryptase as well as other typically used blood markers in forensics are recommended to adopt this method of blood sampling in routine practice.",
author = "Jack Garland and Benjamin Ondruschka and {Da Broi}, Ugo and Cristian Palmiere and Charley Glenn and Paul Morrow and Kilak Kesha and Simon Stables and Rexson Tse",
year = "2021",
doi = "doi.org/10.1177/0025802421998851",
language = "English",
volume = "61",
pages = "250--255",
journal = "MED SCI LAW",
issn = "0025-8024",
publisher = "SAGE Publications",
number = "4",

}

RIS

TY - JOUR

T1 - Levels of haemolysis have no effect on femoral vein post-mortem tryptase levels

AU - Garland, Jack

AU - Ondruschka, Benjamin

AU - Da Broi, Ugo

AU - Palmiere, Cristian

AU - Glenn, Charley

AU - Morrow, Paul

AU - Kesha, Kilak

AU - Stables, Simon

AU - Tse, Rexson

PY - 2021

Y1 - 2021

N2 - Haemolysis is reported to be an artefact that may alter post-mortem tryptase levels. However, previous studies did not sample peripheral blood using newly standardised methods. Recent studies have shown that some previously recognised peri- and post-mortem confounders can be muted by careful sample collection with first clamping and then sampling the femoral vein. This prospective study investigated the relationship between the degree of haemolysis of the blood samples and femoral vein post-mortem tryptase levels when sampled using this recommended method. Seventy consecutive post-mortem tryptase levels in non-anaphylactic deaths were compared to the degree of haemolysis of these samples, and results showed no significant correlation between them. The mean post-mortem tryptase level was 9.5 μg/L. This study demonstrated that the effects of haemolysis on femoral vein post-mortem tryptase was negligible when the blood was sampled using the recommended sampling method. Future studies on post-mortem tryptase as well as other typically used blood markers in forensics are recommended to adopt this method of blood sampling in routine practice.

AB - Haemolysis is reported to be an artefact that may alter post-mortem tryptase levels. However, previous studies did not sample peripheral blood using newly standardised methods. Recent studies have shown that some previously recognised peri- and post-mortem confounders can be muted by careful sample collection with first clamping and then sampling the femoral vein. This prospective study investigated the relationship between the degree of haemolysis of the blood samples and femoral vein post-mortem tryptase levels when sampled using this recommended method. Seventy consecutive post-mortem tryptase levels in non-anaphylactic deaths were compared to the degree of haemolysis of these samples, and results showed no significant correlation between them. The mean post-mortem tryptase level was 9.5 μg/L. This study demonstrated that the effects of haemolysis on femoral vein post-mortem tryptase was negligible when the blood was sampled using the recommended sampling method. Future studies on post-mortem tryptase as well as other typically used blood markers in forensics are recommended to adopt this method of blood sampling in routine practice.

U2 - doi.org/10.1177/0025802421998851

DO - doi.org/10.1177/0025802421998851

M3 - SCORING: Journal article

VL - 61

SP - 250

EP - 255

JO - MED SCI LAW

JF - MED SCI LAW

SN - 0025-8024

IS - 4

ER -