Levels of haemolysis have no effect on femoral vein post-mortem tryptase levels
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Levels of haemolysis have no effect on femoral vein post-mortem tryptase levels. / Garland, Jack; Ondruschka, Benjamin; Da Broi, Ugo; Palmiere, Cristian; Glenn, Charley; Morrow, Paul; Kesha, Kilak; Stables, Simon; Tse, Rexson.
in: MED SCI LAW, Jahrgang 61, Nr. 4, 2021, S. 250-255.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Levels of haemolysis have no effect on femoral vein post-mortem tryptase levels
AU - Garland, Jack
AU - Ondruschka, Benjamin
AU - Da Broi, Ugo
AU - Palmiere, Cristian
AU - Glenn, Charley
AU - Morrow, Paul
AU - Kesha, Kilak
AU - Stables, Simon
AU - Tse, Rexson
PY - 2021
Y1 - 2021
N2 - Haemolysis is reported to be an artefact that may alter post-mortem tryptase levels. However, previous studies did not sample peripheral blood using newly standardised methods. Recent studies have shown that some previously recognised peri- and post-mortem confounders can be muted by careful sample collection with first clamping and then sampling the femoral vein. This prospective study investigated the relationship between the degree of haemolysis of the blood samples and femoral vein post-mortem tryptase levels when sampled using this recommended method. Seventy consecutive post-mortem tryptase levels in non-anaphylactic deaths were compared to the degree of haemolysis of these samples, and results showed no significant correlation between them. The mean post-mortem tryptase level was 9.5 μg/L. This study demonstrated that the effects of haemolysis on femoral vein post-mortem tryptase was negligible when the blood was sampled using the recommended sampling method. Future studies on post-mortem tryptase as well as other typically used blood markers in forensics are recommended to adopt this method of blood sampling in routine practice.
AB - Haemolysis is reported to be an artefact that may alter post-mortem tryptase levels. However, previous studies did not sample peripheral blood using newly standardised methods. Recent studies have shown that some previously recognised peri- and post-mortem confounders can be muted by careful sample collection with first clamping and then sampling the femoral vein. This prospective study investigated the relationship between the degree of haemolysis of the blood samples and femoral vein post-mortem tryptase levels when sampled using this recommended method. Seventy consecutive post-mortem tryptase levels in non-anaphylactic deaths were compared to the degree of haemolysis of these samples, and results showed no significant correlation between them. The mean post-mortem tryptase level was 9.5 μg/L. This study demonstrated that the effects of haemolysis on femoral vein post-mortem tryptase was negligible when the blood was sampled using the recommended sampling method. Future studies on post-mortem tryptase as well as other typically used blood markers in forensics are recommended to adopt this method of blood sampling in routine practice.
U2 - doi.org/10.1177/0025802421998851
DO - doi.org/10.1177/0025802421998851
M3 - SCORING: Journal article
VL - 61
SP - 250
EP - 255
JO - MED SCI LAW
JF - MED SCI LAW
SN - 0025-8024
IS - 4
ER -