Leptin Raises Defended Body Temperature without Activating Thermogenesis
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Leptin Raises Defended Body Temperature without Activating Thermogenesis. / Fischer, Alexander W; Hoefig, Carolin S; Abreu-Vieira, Gustavo; de Jong, Jasper M A; Petrovic, Natasa; Mittag, Jens; Cannon, Barbara; Nedergaard, Jan.
In: CELL REP, Vol. 14, No. 7, 23.02.2016, p. 1621-31.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Leptin Raises Defended Body Temperature without Activating Thermogenesis
AU - Fischer, Alexander W
AU - Hoefig, Carolin S
AU - Abreu-Vieira, Gustavo
AU - de Jong, Jasper M A
AU - Petrovic, Natasa
AU - Mittag, Jens
AU - Cannon, Barbara
AU - Nedergaard, Jan
N1 - Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2016/2/23
Y1 - 2016/2/23
N2 - Leptin has been believed to exert its weight-reducing action not only by inducing hypophagia but also by increasing energy expenditure/thermogenesis. Leptin-deficient ob/ob mice have correspondingly been thought to be thermogenically limited and to show hypothermia, mainly due to atrophied brown adipose tissue (BAT). In contrast to these established views, we found that BAT is fully functional and that leptin treatment did not increase thermogenesis in wild-type or in ob/ob mice. Rather, ob/ob mice showed a decreased but defended body temperature (i.e., were anapyrexic, not hypothermic) that was normalized to wild-type levels after leptin treatment. This was not accompanied by increased energy expenditure or BAT recruitment but, instead, was mediated by decreased tail heat loss. The weight-reducing hypophagic effects of leptin are, therefore, not augmented through a thermogenic effect of leptin; leptin is, however, pyrexic, i.e., it alters centrally regulated thresholds of thermoregulatory mechanisms, in parallel to effects of other cytokines.
AB - Leptin has been believed to exert its weight-reducing action not only by inducing hypophagia but also by increasing energy expenditure/thermogenesis. Leptin-deficient ob/ob mice have correspondingly been thought to be thermogenically limited and to show hypothermia, mainly due to atrophied brown adipose tissue (BAT). In contrast to these established views, we found that BAT is fully functional and that leptin treatment did not increase thermogenesis in wild-type or in ob/ob mice. Rather, ob/ob mice showed a decreased but defended body temperature (i.e., were anapyrexic, not hypothermic) that was normalized to wild-type levels after leptin treatment. This was not accompanied by increased energy expenditure or BAT recruitment but, instead, was mediated by decreased tail heat loss. The weight-reducing hypophagic effects of leptin are, therefore, not augmented through a thermogenic effect of leptin; leptin is, however, pyrexic, i.e., it alters centrally regulated thresholds of thermoregulatory mechanisms, in parallel to effects of other cytokines.
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.celrep.2016.01.041
DO - 10.1016/j.celrep.2016.01.041
M3 - SCORING: Journal article
C2 - 26876182
VL - 14
SP - 1621
EP - 1631
JO - CELL REP
JF - CELL REP
SN - 2211-1247
IS - 7
ER -