Leptin Raises Defended Body Temperature without Activating Thermogenesis

Alexander W Fischer; Carolin S Hoefig; Gustavo Abreu-Vieira; Jasper M A de Jong; Natasa Petrovic; Jens Mittag; Barbara Cannon; Jan Nedergaard

doi:10.1016/j.celrep.2016.01.041

Leptin Raises Defended Body Temperature without Activating Thermogenesis

Standard

Leptin Raises Defended Body Temperature without Activating Thermogenesis. / Fischer, Alexander W; Hoefig, Carolin S; Abreu-Vieira, Gustavo; de Jong, Jasper M A; Petrovic, Natasa; Mittag, Jens; Cannon, Barbara; Nedergaard, Jan.

in: CELL REP, Jahrgang 14, Nr. 7, 23.02.2016, S. 1621-31.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fischer, AW, Hoefig, CS, Abreu-Vieira, G, de Jong, JMA, Petrovic, N, Mittag, J, Cannon, B & Nedergaard, J 2016, 'Leptin Raises Defended Body Temperature without Activating Thermogenesis', CELL REP, Jg. 14, Nr. 7, S. 1621-31. https://doi.org/10.1016/j.celrep.2016.01.041

APA

Fischer, A. W., Hoefig, C. S., Abreu-Vieira, G., de Jong, J. M. A., Petrovic, N., Mittag, J., Cannon, B., & Nedergaard, J. (2016). Leptin Raises Defended Body Temperature without Activating Thermogenesis. CELL REP, 14(7), 1621-31. https://doi.org/10.1016/j.celrep.2016.01.041

Vancouver

Fischer AW, Hoefig CS, Abreu-Vieira G, de Jong JMA, Petrovic N, Mittag J et al. Leptin Raises Defended Body Temperature without Activating Thermogenesis. CELL REP. 2016 Feb 23;14(7):1621-31. https://doi.org/10.1016/j.celrep.2016.01.041

Bibtex

@article{5b2267bb614c460a924166c0ebeb0a11,

title = "Leptin Raises Defended Body Temperature without Activating Thermogenesis",

abstract = "Leptin has been believed to exert its weight-reducing action not only by inducing hypophagia but also by increasing energy expenditure/thermogenesis. Leptin-deficient ob/ob mice have correspondingly been thought to be thermogenically limited and to show hypothermia, mainly due to atrophied brown adipose tissue (BAT). In contrast to these established views, we found that BAT is fully functional and that leptin treatment did not increase thermogenesis in wild-type or in ob/ob mice. Rather, ob/ob mice showed a decreased but defended body temperature (i.e., were anapyrexic, not hypothermic) that was normalized to wild-type levels after leptin treatment. This was not accompanied by increased energy expenditure or BAT recruitment but, instead, was mediated by decreased tail heat loss. The weight-reducing hypophagic effects of leptin are, therefore, not augmented through a thermogenic effect of leptin; leptin is, however, pyrexic, i.e., it alters centrally regulated thresholds of thermoregulatory mechanisms, in parallel to effects of other cytokines.",

keywords = "Journal Article, Research Support, Non-U.S. Gov't",

author = "Fischer, {Alexander W} and Hoefig, {Carolin S} and Gustavo Abreu-Vieira and {de Jong}, {Jasper M A} and Natasa Petrovic and Jens Mittag and Barbara Cannon and Jan Nedergaard",

year = "2016",

month = feb,

day = "23",

doi = "10.1016/j.celrep.2016.01.041",

language = "English",

volume = "14",

pages = "1621--31",

journal = "CELL REP",

issn = "2211-1247",

publisher = "Elsevier",

number = "7",

}

RIS

TY - JOUR

T1 - Leptin Raises Defended Body Temperature without Activating Thermogenesis

AU - Fischer, Alexander W

AU - Hoefig, Carolin S

AU - Abreu-Vieira, Gustavo

AU - de Jong, Jasper M A

AU - Petrovic, Natasa

AU - Mittag, Jens

AU - Cannon, Barbara

AU - Nedergaard, Jan

PY - 2016/2/23

Y1 - 2016/2/23

N2 - Leptin has been believed to exert its weight-reducing action not only by inducing hypophagia but also by increasing energy expenditure/thermogenesis. Leptin-deficient ob/ob mice have correspondingly been thought to be thermogenically limited and to show hypothermia, mainly due to atrophied brown adipose tissue (BAT). In contrast to these established views, we found that BAT is fully functional and that leptin treatment did not increase thermogenesis in wild-type or in ob/ob mice. Rather, ob/ob mice showed a decreased but defended body temperature (i.e., were anapyrexic, not hypothermic) that was normalized to wild-type levels after leptin treatment. This was not accompanied by increased energy expenditure or BAT recruitment but, instead, was mediated by decreased tail heat loss. The weight-reducing hypophagic effects of leptin are, therefore, not augmented through a thermogenic effect of leptin; leptin is, however, pyrexic, i.e., it alters centrally regulated thresholds of thermoregulatory mechanisms, in parallel to effects of other cytokines.

AB - Leptin has been believed to exert its weight-reducing action not only by inducing hypophagia but also by increasing energy expenditure/thermogenesis. Leptin-deficient ob/ob mice have correspondingly been thought to be thermogenically limited and to show hypothermia, mainly due to atrophied brown adipose tissue (BAT). In contrast to these established views, we found that BAT is fully functional and that leptin treatment did not increase thermogenesis in wild-type or in ob/ob mice. Rather, ob/ob mice showed a decreased but defended body temperature (i.e., were anapyrexic, not hypothermic) that was normalized to wild-type levels after leptin treatment. This was not accompanied by increased energy expenditure or BAT recruitment but, instead, was mediated by decreased tail heat loss. The weight-reducing hypophagic effects of leptin are, therefore, not augmented through a thermogenic effect of leptin; leptin is, however, pyrexic, i.e., it alters centrally regulated thresholds of thermoregulatory mechanisms, in parallel to effects of other cytokines.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.celrep.2016.01.041

DO - 10.1016/j.celrep.2016.01.041

M3 - SCORING: Journal article

C2 - 26876182

VL - 14

SP - 1621

EP - 1631

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 7

ER -