Lectin histochemistry of metastatic adenocarcinomas of the lung.
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Lectin histochemistry of metastatic adenocarcinomas of the lung. / Thoem, Ina; Schult-Kronefeld, Olaf; Burkholder, Iris; Goern, Michael; Andritzky, Birte; Blonski, Katharina; Kugler, Christian; Edler, Lutz; Bokemeyer, Carsten; Schumacher, Udo; Laack, Eckart.
In: LUNG CANCER, Vol. 56, No. 3, 3, 2007, p. 391-397.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Lectin histochemistry of metastatic adenocarcinomas of the lung.
AU - Thoem, Ina
AU - Schult-Kronefeld, Olaf
AU - Burkholder, Iris
AU - Goern, Michael
AU - Andritzky, Birte
AU - Blonski, Katharina
AU - Kugler, Christian
AU - Edler, Lutz
AU - Bokemeyer, Carsten
AU - Schumacher, Udo
AU - Laack, Eckart
PY - 2007
Y1 - 2007
N2 - BACKGROUND: Several clinical studies indicate that primary tumour cells with high metastatic potential often show aberrant glycosylation as detected by lectin histochemistry. However, it is unclear whether aberrant glycosylation is still present in metastatic deposits. The aim of the present investigation was thus to analyse a possible association between the presence of lectin binding sites of pulmonary adenocarcinoma cells and their lymph node and haematogenous metastatic cells. METHODS: For this purpose, the expression of HPA, PHA-L and UEA-I was assessed in primary tumours, lymph node metastases and haematogenous metastases of 96 patients with metastatic adenocarcinomas of the lung that underwent surgery between 1999 and 2002. Besides, lectin-binding data and other known prognostic factors were correlated with survival. RESULTS: We found a significant positive correlation between the binding of the lectins HPA (p=0.002), PHA-L (p
AB - BACKGROUND: Several clinical studies indicate that primary tumour cells with high metastatic potential often show aberrant glycosylation as detected by lectin histochemistry. However, it is unclear whether aberrant glycosylation is still present in metastatic deposits. The aim of the present investigation was thus to analyse a possible association between the presence of lectin binding sites of pulmonary adenocarcinoma cells and their lymph node and haematogenous metastatic cells. METHODS: For this purpose, the expression of HPA, PHA-L and UEA-I was assessed in primary tumours, lymph node metastases and haematogenous metastases of 96 patients with metastatic adenocarcinomas of the lung that underwent surgery between 1999 and 2002. Besides, lectin-binding data and other known prognostic factors were correlated with survival. RESULTS: We found a significant positive correlation between the binding of the lectins HPA (p=0.002), PHA-L (p
M3 - SCORING: Zeitschriftenaufsatz
VL - 56
SP - 391
EP - 397
JO - LUNG CANCER
JF - LUNG CANCER
SN - 0169-5002
IS - 3
M1 - 3
ER -