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Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals.

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Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals. / Addo, Marylyn; Altfeld, Marcus; Brainard, Diana M; Rathod, Almas; Piechocka-Trocha, Alicja; Fideli, Ulgen; Mulenga, Joseph; Shutes, Erin; Alvino, Donna Marie L; Hunter, Eric; Allen, Susan A; Walker, Bruce D.

In: J INFECT DIS, Vol. 203, No. 2, 2, 2011, p. 258-262.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Addo, M, Altfeld, M, Brainard, DM, Rathod, A, Piechocka-Trocha, A, Fideli, U, Mulenga, J, Shutes, E, Alvino, DML, Hunter, E, Allen, SA & Walker, BD 2011, 'Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals.', J INFECT DIS, vol. 203, no. 2, 2, pp. 258-262. <http://www.ncbi.nlm.nih.gov/pubmed/21288826?dopt=Citation>

APA

Addo, M., Altfeld, M., Brainard, D. M., Rathod, A., Piechocka-Trocha, A., Fideli, U., Mulenga, J., Shutes, E., Alvino, D. M. L., Hunter, E., Allen, S. A., & Walker, B. D. (2011). Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals. J INFECT DIS, 203(2), 258-262. [2]. http://www.ncbi.nlm.nih.gov/pubmed/21288826?dopt=Citation

Vancouver

Addo M, Altfeld M, Brainard DM, Rathod A, Piechocka-Trocha A, Fideli U et al. Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals. J INFECT DIS. 2011;203(2):258-262. 2.

Bibtex

@article{6ff5fddf5388463f8806a06d67e16a1c,
title = "Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals.",
abstract = "Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1-specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1-specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1-specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals.",
keywords = "Humans, Male, Female, Immunity, Innate, *Sexual Partners, CD8-Positive T-Lymphocytes/*immunology, HIV-1/*immunology, HIV Infections/*immunology, Zambia, Humans, Male, Female, Immunity, Innate, *Sexual Partners, CD8-Positive T-Lymphocytes/*immunology, HIV-1/*immunology, HIV Infections/*immunology, Zambia",
author = "Marylyn Addo and Marcus Altfeld and Brainard, {Diana M} and Almas Rathod and Alicja Piechocka-Trocha and Ulgen Fideli and Joseph Mulenga and Erin Shutes and Alvino, {Donna Marie L} and Eric Hunter and Allen, {Susan A} and Walker, {Bruce D}",
year = "2011",
language = "English",
volume = "203",
pages = "258--262",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals.

AU - Addo, Marylyn

AU - Altfeld, Marcus

AU - Brainard, Diana M

AU - Rathod, Almas

AU - Piechocka-Trocha, Alicja

AU - Fideli, Ulgen

AU - Mulenga, Joseph

AU - Shutes, Erin

AU - Alvino, Donna Marie L

AU - Hunter, Eric

AU - Allen, Susan A

AU - Walker, Bruce D

PY - 2011

Y1 - 2011

N2 - Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1-specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1-specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1-specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals.

AB - Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1-specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1-specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1-specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals.

KW - Humans

KW - Male

KW - Female

KW - Immunity, Innate

KW - Sexual Partners

KW - CD8-Positive T-Lymphocytes/immunology

KW - HIV-1/immunology

KW - HIV Infections/immunology

KW - Zambia

KW - Humans

KW - Male

KW - Female

KW - Immunity, Innate

KW - Sexual Partners

KW - CD8-Positive T-Lymphocytes/immunology

KW - HIV-1/immunology

KW - HIV Infections/immunology

KW - Zambia

M3 - SCORING: Journal article

VL - 203

SP - 258

EP - 262

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 2

M1 - 2

ER -