Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals.
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Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals. / Addo, Marylyn; Altfeld, Marcus; Brainard, Diana M; Rathod, Almas; Piechocka-Trocha, Alicja; Fideli, Ulgen; Mulenga, Joseph; Shutes, Erin; Alvino, Donna Marie L; Hunter, Eric; Allen, Susan A; Walker, Bruce D.
in: J INFECT DIS, Jahrgang 203, Nr. 2, 2, 2011, S. 258-262.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals.
AU - Addo, Marylyn
AU - Altfeld, Marcus
AU - Brainard, Diana M
AU - Rathod, Almas
AU - Piechocka-Trocha, Alicja
AU - Fideli, Ulgen
AU - Mulenga, Joseph
AU - Shutes, Erin
AU - Alvino, Donna Marie L
AU - Hunter, Eric
AU - Allen, Susan A
AU - Walker, Bruce D
PY - 2011
Y1 - 2011
N2 - Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1-specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1-specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1-specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals.
AB - Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1-specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1-specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1-specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals.
KW - Humans
KW - Male
KW - Female
KW - Immunity, Innate
KW - Sexual Partners
KW - CD8-Positive T-Lymphocytes/immunology
KW - HIV-1/immunology
KW - HIV Infections/immunology
KW - Zambia
KW - Humans
KW - Male
KW - Female
KW - Immunity, Innate
KW - Sexual Partners
KW - CD8-Positive T-Lymphocytes/immunology
KW - HIV-1/immunology
KW - HIV Infections/immunology
KW - Zambia
M3 - SCORING: Journal article
VL - 203
SP - 258
EP - 262
JO - J INFECT DIS
JF - J INFECT DIS
SN - 0022-1899
IS - 2
M1 - 2
ER -