Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study
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Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study. / Mutschler, Jochen; Abbruzzese, Elvira; von der Goltz, Christoph; Dinter, Christina; Mobascher, Arian; Thiele, Holger; Diaz-Lacava, Amalia; Dahmen, Norbert; Gallinat, Jürgen; Majic, Tomislav; Petrovsky, Nadine; Thuerauf, Norbert; Kornhuber, Johannes; Gründer, Gerhard; Rademacher, Lena; Brinkmeyer, Juergen; Wienker, Thomas; Wagner, Michael; Winterer, Georg; Kiefer, Falk.
In: NICOTINE TOB RES, Vol. 15, No. 7, 01.07.2013, p. 1322-7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study
AU - Mutschler, Jochen
AU - Abbruzzese, Elvira
AU - von der Goltz, Christoph
AU - Dinter, Christina
AU - Mobascher, Arian
AU - Thiele, Holger
AU - Diaz-Lacava, Amalia
AU - Dahmen, Norbert
AU - Gallinat, Jürgen
AU - Majic, Tomislav
AU - Petrovsky, Nadine
AU - Thuerauf, Norbert
AU - Kornhuber, Johannes
AU - Gründer, Gerhard
AU - Rademacher, Lena
AU - Brinkmeyer, Juergen
AU - Wienker, Thomas
AU - Wagner, Michael
AU - Winterer, Georg
AU - Kiefer, Falk
PY - 2013/7/1
Y1 - 2013/7/1
N2 - BACKGROUND: The catechol-O-methyltransferase (COMT) modulates dopaminergic neurotransmission in the prefrontal cortex as well as in the mesolimbic reward system. Since the reward system mediates addictive behavior, the COMT gene is a strong candidate gene regarding the pathophysiology of tobacco dependence and smoking behavior. Because of rather conflicting results in previous studies, the purpose of the present study was to test for association between a functional genetic variant in the COMT gene (single nucleotide polymorphism [SNP] rs4680) and tobacco smoking behavior.METHODS: In a population-based case-control multicenter study designed for tobacco addiction research, a total of 551 current smokers of European ancestry and 548 age-matched healthy volunteers (never-smokers) were genotyped for SNP rs4680 and extensively characterized concerning their smoking behavior.RESULTS: We found no association between smoking status and SNP rs4680 genotype nor did we find a significant association to the degree of tobacco dependence.CONCLUSIONS: Although prefrontal cortical and ventral striatal activity are highly relevant for addictive behavior, and under partial control of COMT rs4680 genotype, no association between COMT and smoking behavior was observed. Other genetic variants may account for the high heritability of behavioral smoking phenotypes.
AB - BACKGROUND: The catechol-O-methyltransferase (COMT) modulates dopaminergic neurotransmission in the prefrontal cortex as well as in the mesolimbic reward system. Since the reward system mediates addictive behavior, the COMT gene is a strong candidate gene regarding the pathophysiology of tobacco dependence and smoking behavior. Because of rather conflicting results in previous studies, the purpose of the present study was to test for association between a functional genetic variant in the COMT gene (single nucleotide polymorphism [SNP] rs4680) and tobacco smoking behavior.METHODS: In a population-based case-control multicenter study designed for tobacco addiction research, a total of 551 current smokers of European ancestry and 548 age-matched healthy volunteers (never-smokers) were genotyped for SNP rs4680 and extensively characterized concerning their smoking behavior.RESULTS: We found no association between smoking status and SNP rs4680 genotype nor did we find a significant association to the degree of tobacco dependence.CONCLUSIONS: Although prefrontal cortical and ventral striatal activity are highly relevant for addictive behavior, and under partial control of COMT rs4680 genotype, no association between COMT and smoking behavior was observed. Other genetic variants may account for the high heritability of behavioral smoking phenotypes.
KW - Adult
KW - Case-Control Studies
KW - Catechol O-Methyltransferase
KW - European Continental Ancestry Group
KW - Germany
KW - Humans
KW - Middle Aged
KW - Polymorphism, Single Nucleotide
KW - Smoking
KW - Tobacco Use Disorder
U2 - 10.1093/ntr/nts334
DO - 10.1093/ntr/nts334
M3 - SCORING: Journal article
C2 - 23288874
VL - 15
SP - 1322
EP - 1327
JO - NICOTINE TOB RES
JF - NICOTINE TOB RES
SN - 1462-2203
IS - 7
ER -