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Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study

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Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study. / Mutschler, Jochen; Abbruzzese, Elvira; von der Goltz, Christoph; Dinter, Christina; Mobascher, Arian; Thiele, Holger; Diaz-Lacava, Amalia; Dahmen, Norbert; Gallinat, Jürgen; Majic, Tomislav; Petrovsky, Nadine; Thuerauf, Norbert; Kornhuber, Johannes; Gründer, Gerhard; Rademacher, Lena; Brinkmeyer, Juergen; Wienker, Thomas; Wagner, Michael; Winterer, Georg; Kiefer, Falk.

in: NICOTINE TOB RES, Jahrgang 15, Nr. 7, 01.07.2013, S. 1322-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mutschler, J, Abbruzzese, E, von der Goltz, C, Dinter, C, Mobascher, A, Thiele, H, Diaz-Lacava, A, Dahmen, N, Gallinat, J, Majic, T, Petrovsky, N, Thuerauf, N, Kornhuber, J, Gründer, G, Rademacher, L, Brinkmeyer, J, Wienker, T, Wagner, M, Winterer, G & Kiefer, F 2013, 'Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study', NICOTINE TOB RES, Jg. 15, Nr. 7, S. 1322-7. https://doi.org/10.1093/ntr/nts334

APA

Mutschler, J., Abbruzzese, E., von der Goltz, C., Dinter, C., Mobascher, A., Thiele, H., Diaz-Lacava, A., Dahmen, N., Gallinat, J., Majic, T., Petrovsky, N., Thuerauf, N., Kornhuber, J., Gründer, G., Rademacher, L., Brinkmeyer, J., Wienker, T., Wagner, M., Winterer, G., & Kiefer, F. (2013). Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study. NICOTINE TOB RES, 15(7), 1322-7. https://doi.org/10.1093/ntr/nts334

Vancouver

Mutschler J, Abbruzzese E, von der Goltz C, Dinter C, Mobascher A, Thiele H et al. Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study. NICOTINE TOB RES. 2013 Jul 1;15(7):1322-7. https://doi.org/10.1093/ntr/nts334

Bibtex

@article{062ca41d06ac40faae3db32498a740ab,
title = "Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study",
abstract = "BACKGROUND: The catechol-O-methyltransferase (COMT) modulates dopaminergic neurotransmission in the prefrontal cortex as well as in the mesolimbic reward system. Since the reward system mediates addictive behavior, the COMT gene is a strong candidate gene regarding the pathophysiology of tobacco dependence and smoking behavior. Because of rather conflicting results in previous studies, the purpose of the present study was to test for association between a functional genetic variant in the COMT gene (single nucleotide polymorphism [SNP] rs4680) and tobacco smoking behavior.METHODS: In a population-based case-control multicenter study designed for tobacco addiction research, a total of 551 current smokers of European ancestry and 548 age-matched healthy volunteers (never-smokers) were genotyped for SNP rs4680 and extensively characterized concerning their smoking behavior.RESULTS: We found no association between smoking status and SNP rs4680 genotype nor did we find a significant association to the degree of tobacco dependence.CONCLUSIONS: Although prefrontal cortical and ventral striatal activity are highly relevant for addictive behavior, and under partial control of COMT rs4680 genotype, no association between COMT and smoking behavior was observed. Other genetic variants may account for the high heritability of behavioral smoking phenotypes.",
keywords = "Adult, Case-Control Studies, Catechol O-Methyltransferase, European Continental Ancestry Group, Germany, Humans, Middle Aged, Polymorphism, Single Nucleotide, Smoking, Tobacco Use Disorder",
author = "Jochen Mutschler and Elvira Abbruzzese and {von der Goltz}, Christoph and Christina Dinter and Arian Mobascher and Holger Thiele and Amalia Diaz-Lacava and Norbert Dahmen and J{\"u}rgen Gallinat and Tomislav Majic and Nadine Petrovsky and Norbert Thuerauf and Johannes Kornhuber and Gerhard Gr{\"u}nder and Lena Rademacher and Juergen Brinkmeyer and Thomas Wienker and Michael Wagner and Georg Winterer and Falk Kiefer",
year = "2013",
month = jul,
day = "1",
doi = "10.1093/ntr/nts334",
language = "English",
volume = "15",
pages = "1322--7",
journal = "NICOTINE TOB RES",
issn = "1462-2203",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study

AU - Mutschler, Jochen

AU - Abbruzzese, Elvira

AU - von der Goltz, Christoph

AU - Dinter, Christina

AU - Mobascher, Arian

AU - Thiele, Holger

AU - Diaz-Lacava, Amalia

AU - Dahmen, Norbert

AU - Gallinat, Jürgen

AU - Majic, Tomislav

AU - Petrovsky, Nadine

AU - Thuerauf, Norbert

AU - Kornhuber, Johannes

AU - Gründer, Gerhard

AU - Rademacher, Lena

AU - Brinkmeyer, Juergen

AU - Wienker, Thomas

AU - Wagner, Michael

AU - Winterer, Georg

AU - Kiefer, Falk

PY - 2013/7/1

Y1 - 2013/7/1

N2 - BACKGROUND: The catechol-O-methyltransferase (COMT) modulates dopaminergic neurotransmission in the prefrontal cortex as well as in the mesolimbic reward system. Since the reward system mediates addictive behavior, the COMT gene is a strong candidate gene regarding the pathophysiology of tobacco dependence and smoking behavior. Because of rather conflicting results in previous studies, the purpose of the present study was to test for association between a functional genetic variant in the COMT gene (single nucleotide polymorphism [SNP] rs4680) and tobacco smoking behavior.METHODS: In a population-based case-control multicenter study designed for tobacco addiction research, a total of 551 current smokers of European ancestry and 548 age-matched healthy volunteers (never-smokers) were genotyped for SNP rs4680 and extensively characterized concerning their smoking behavior.RESULTS: We found no association between smoking status and SNP rs4680 genotype nor did we find a significant association to the degree of tobacco dependence.CONCLUSIONS: Although prefrontal cortical and ventral striatal activity are highly relevant for addictive behavior, and under partial control of COMT rs4680 genotype, no association between COMT and smoking behavior was observed. Other genetic variants may account for the high heritability of behavioral smoking phenotypes.

AB - BACKGROUND: The catechol-O-methyltransferase (COMT) modulates dopaminergic neurotransmission in the prefrontal cortex as well as in the mesolimbic reward system. Since the reward system mediates addictive behavior, the COMT gene is a strong candidate gene regarding the pathophysiology of tobacco dependence and smoking behavior. Because of rather conflicting results in previous studies, the purpose of the present study was to test for association between a functional genetic variant in the COMT gene (single nucleotide polymorphism [SNP] rs4680) and tobacco smoking behavior.METHODS: In a population-based case-control multicenter study designed for tobacco addiction research, a total of 551 current smokers of European ancestry and 548 age-matched healthy volunteers (never-smokers) were genotyped for SNP rs4680 and extensively characterized concerning their smoking behavior.RESULTS: We found no association between smoking status and SNP rs4680 genotype nor did we find a significant association to the degree of tobacco dependence.CONCLUSIONS: Although prefrontal cortical and ventral striatal activity are highly relevant for addictive behavior, and under partial control of COMT rs4680 genotype, no association between COMT and smoking behavior was observed. Other genetic variants may account for the high heritability of behavioral smoking phenotypes.

KW - Adult

KW - Case-Control Studies

KW - Catechol O-Methyltransferase

KW - European Continental Ancestry Group

KW - Germany

KW - Humans

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Smoking

KW - Tobacco Use Disorder

U2 - 10.1093/ntr/nts334

DO - 10.1093/ntr/nts334

M3 - SCORING: Journal article

C2 - 23288874

VL - 15

SP - 1322

EP - 1327

JO - NICOTINE TOB RES

JF - NICOTINE TOB RES

SN - 1462-2203

IS - 7

ER -