L1.1 is involved in spinal cord regeneration in adult zebrafish
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L1.1 is involved in spinal cord regeneration in adult zebrafish. / Becker, Catherina G; Lieberoth, Bettina C; Morellini, Fabio; Feldner, Julia; Becker, Thomas; Schachner, Melitta.
In: J NEUROSCI, Vol. 24, No. 36, 08.09.2004, p. 7837-42.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - L1.1 is involved in spinal cord regeneration in adult zebrafish
AU - Becker, Catherina G
AU - Lieberoth, Bettina C
AU - Morellini, Fabio
AU - Feldner, Julia
AU - Becker, Thomas
AU - Schachner, Melitta
PY - 2004/9/8
Y1 - 2004/9/8
N2 - Adult zebrafish, in contrast to mammals, regrow axons descending from the brainstem after spinal cord transection. L1.1, a homolog of the mammalian recognition molecule L1, is upregulated by brainstem neurons during axon regrowth. However, its functional relevance for regeneration is unclear. Here, we show with a novel morpholino-based approach that reducing L1.1 protein expression leads to impaired locomotor recovery as well as reduced regrowth and synapse formation of axons of supraspinal origin after spinal cord transection. This indicates that L1.1 contributes to successful regrowth of axons from the brainstem and locomotor recovery after spinal cord transection in adult zebrafish.
AB - Adult zebrafish, in contrast to mammals, regrow axons descending from the brainstem after spinal cord transection. L1.1, a homolog of the mammalian recognition molecule L1, is upregulated by brainstem neurons during axon regrowth. However, its functional relevance for regeneration is unclear. Here, we show with a novel morpholino-based approach that reducing L1.1 protein expression leads to impaired locomotor recovery as well as reduced regrowth and synapse formation of axons of supraspinal origin after spinal cord transection. This indicates that L1.1 contributes to successful regrowth of axons from the brainstem and locomotor recovery after spinal cord transection in adult zebrafish.
KW - Animals
KW - Axons
KW - Brain Stem
KW - Cordotomy
KW - Drug Implants
KW - Gelatin Sponge, Absorbable
KW - Morpholines
KW - Nerve Regeneration
KW - Oligodeoxyribonucleotides
KW - Recovery of Function
KW - Single-Blind Method
KW - Spinal Cord
KW - Spinal Cord Injuries
KW - Swimming
KW - Zebrafish
U2 - 10.1523/JNEUROSCI.2420-04.2004
DO - 10.1523/JNEUROSCI.2420-04.2004
M3 - SCORING: Journal article
C2 - 15356195
VL - 24
SP - 7837
EP - 7842
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 36
ER -