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L1.1 is involved in spinal cord regeneration in adult zebrafish

Standard

L1.1 is involved in spinal cord regeneration in adult zebrafish. / Becker, Catherina G; Lieberoth, Bettina C; Morellini, Fabio; Feldner, Julia; Becker, Thomas; Schachner, Melitta.

in: J NEUROSCI, Jahrgang 24, Nr. 36, 08.09.2004, S. 7837-42.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Becker, CG, Lieberoth, BC, Morellini, F, Feldner, J, Becker, T & Schachner, M 2004, 'L1.1 is involved in spinal cord regeneration in adult zebrafish', J NEUROSCI, Jg. 24, Nr. 36, S. 7837-42. https://doi.org/10.1523/JNEUROSCI.2420-04.2004

APA

Becker, C. G., Lieberoth, B. C., Morellini, F., Feldner, J., Becker, T., & Schachner, M. (2004). L1.1 is involved in spinal cord regeneration in adult zebrafish. J NEUROSCI, 24(36), 7837-42. https://doi.org/10.1523/JNEUROSCI.2420-04.2004

Vancouver

Becker CG, Lieberoth BC, Morellini F, Feldner J, Becker T, Schachner M. L1.1 is involved in spinal cord regeneration in adult zebrafish. J NEUROSCI. 2004 Sep 8;24(36):7837-42. https://doi.org/10.1523/JNEUROSCI.2420-04.2004

Bibtex

@article{243abd93a3ec4fa0bf1e8d07ebcba791,
title = "L1.1 is involved in spinal cord regeneration in adult zebrafish",
abstract = "Adult zebrafish, in contrast to mammals, regrow axons descending from the brainstem after spinal cord transection. L1.1, a homolog of the mammalian recognition molecule L1, is upregulated by brainstem neurons during axon regrowth. However, its functional relevance for regeneration is unclear. Here, we show with a novel morpholino-based approach that reducing L1.1 protein expression leads to impaired locomotor recovery as well as reduced regrowth and synapse formation of axons of supraspinal origin after spinal cord transection. This indicates that L1.1 contributes to successful regrowth of axons from the brainstem and locomotor recovery after spinal cord transection in adult zebrafish.",
keywords = "Animals, Axons, Brain Stem, Cordotomy, Drug Implants, Gelatin Sponge, Absorbable, Morpholines, Nerve Regeneration, Oligodeoxyribonucleotides, Recovery of Function, Single-Blind Method, Spinal Cord, Spinal Cord Injuries, Swimming, Zebrafish",
author = "Becker, {Catherina G} and Lieberoth, {Bettina C} and Fabio Morellini and Julia Feldner and Thomas Becker and Melitta Schachner",
year = "2004",
month = sep,
day = "8",
doi = "10.1523/JNEUROSCI.2420-04.2004",
language = "English",
volume = "24",
pages = "7837--42",
journal = "J NEUROSCI",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "36",

}

RIS

TY - JOUR

T1 - L1.1 is involved in spinal cord regeneration in adult zebrafish

AU - Becker, Catherina G

AU - Lieberoth, Bettina C

AU - Morellini, Fabio

AU - Feldner, Julia

AU - Becker, Thomas

AU - Schachner, Melitta

PY - 2004/9/8

Y1 - 2004/9/8

N2 - Adult zebrafish, in contrast to mammals, regrow axons descending from the brainstem after spinal cord transection. L1.1, a homolog of the mammalian recognition molecule L1, is upregulated by brainstem neurons during axon regrowth. However, its functional relevance for regeneration is unclear. Here, we show with a novel morpholino-based approach that reducing L1.1 protein expression leads to impaired locomotor recovery as well as reduced regrowth and synapse formation of axons of supraspinal origin after spinal cord transection. This indicates that L1.1 contributes to successful regrowth of axons from the brainstem and locomotor recovery after spinal cord transection in adult zebrafish.

AB - Adult zebrafish, in contrast to mammals, regrow axons descending from the brainstem after spinal cord transection. L1.1, a homolog of the mammalian recognition molecule L1, is upregulated by brainstem neurons during axon regrowth. However, its functional relevance for regeneration is unclear. Here, we show with a novel morpholino-based approach that reducing L1.1 protein expression leads to impaired locomotor recovery as well as reduced regrowth and synapse formation of axons of supraspinal origin after spinal cord transection. This indicates that L1.1 contributes to successful regrowth of axons from the brainstem and locomotor recovery after spinal cord transection in adult zebrafish.

KW - Animals

KW - Axons

KW - Brain Stem

KW - Cordotomy

KW - Drug Implants

KW - Gelatin Sponge, Absorbable

KW - Morpholines

KW - Nerve Regeneration

KW - Oligodeoxyribonucleotides

KW - Recovery of Function

KW - Single-Blind Method

KW - Spinal Cord

KW - Spinal Cord Injuries

KW - Swimming

KW - Zebrafish

U2 - 10.1523/JNEUROSCI.2420-04.2004

DO - 10.1523/JNEUROSCI.2420-04.2004

M3 - SCORING: Journal article

C2 - 15356195

VL - 24

SP - 7837

EP - 7842

JO - J NEUROSCI

JF - J NEUROSCI

SN - 0270-6474

IS - 36

ER -