L1 is associated with micrometastatic spread and poor outcome in colorectal cancer.
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L1 is associated with micrometastatic spread and poor outcome in colorectal cancer. / Kaifi, Jussuf; Reichelt, Uta; Quaas, Alexander; Schurr, Paulus; Wachowiak, Robin; Yekebas, Emre F.; Strate, Tim; Schneider, Claus G.; Pantel, Klaus; Schachner, Melitta; Sauter, Guido; Izbicki, Jakob R.
In: MODERN PATHOL, Vol. 20, No. 11, 11, 2007, p. 1183-1190.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - L1 is associated with micrometastatic spread and poor outcome in colorectal cancer.
AU - Kaifi, Jussuf
AU - Reichelt, Uta
AU - Quaas, Alexander
AU - Schurr, Paulus
AU - Wachowiak, Robin
AU - Yekebas, Emre F.
AU - Strate, Tim
AU - Schneider, Claus G.
AU - Pantel, Klaus
AU - Schachner, Melitta
AU - Sauter, Guido
AU - Izbicki, Jakob R.
PY - 2007
Y1 - 2007
N2 - L1 is a cell adhesion molecule expressed at the invasive front of colorectal tumors with an important role in metastasis. The aim of the present study was to determine L1 protein expression in a large cohort of colorectal cancer patients and its impact on early metastatic spread and survival. A total of 375 patients that underwent surgical treatment for colorectal cancer were chosen retrospectively. A tissue microarray was constructed of 576 tissue samples from these patients and analyzed by immunohistochemistry with a monoclonal antibody against human L1 (UJ127). Lymph node and bone marrow micrometastasis were assessed with monoclonal antibodies Ber-EP4 and pancytokeratin A45-B/B3, respectively. Associations between L1 expression and lymph node, bone marrow micrometastasis and survival were investigated with Fisher's, log-rank test and Cox multivariate analysis. All statistical tests were two-sided. L1 was detected in a subset of 48 (13%) of 375 patients examined. Analysis of L1 expression and survival revealed a significantly worse outcome for L1-positive patients by log-rank test (P
AB - L1 is a cell adhesion molecule expressed at the invasive front of colorectal tumors with an important role in metastasis. The aim of the present study was to determine L1 protein expression in a large cohort of colorectal cancer patients and its impact on early metastatic spread and survival. A total of 375 patients that underwent surgical treatment for colorectal cancer were chosen retrospectively. A tissue microarray was constructed of 576 tissue samples from these patients and analyzed by immunohistochemistry with a monoclonal antibody against human L1 (UJ127). Lymph node and bone marrow micrometastasis were assessed with monoclonal antibodies Ber-EP4 and pancytokeratin A45-B/B3, respectively. Associations between L1 expression and lymph node, bone marrow micrometastasis and survival were investigated with Fisher's, log-rank test and Cox multivariate analysis. All statistical tests were two-sided. L1 was detected in a subset of 48 (13%) of 375 patients examined. Analysis of L1 expression and survival revealed a significantly worse outcome for L1-positive patients by log-rank test (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 20
SP - 1183
EP - 1190
JO - MODERN PATHOL
JF - MODERN PATHOL
SN - 0893-3952
IS - 11
M1 - 11
ER -