KRAS Mutation in an Implant-associated Peripheral Giant Cell Granuloma of the Jaw: Implications of Genetic Analysis of the Lesion for Treatment Concept and Surveillance

Reinhard E Friedrich; Falk Wüsthoff; Andreas M Luebke; Felix K Kohlrusch; Ilse Wieland; Martin Zenker; Martin Gosau

doi:10.21873/invivo.12335

KRAS Mutation in an Implant-associated Peripheral Giant Cell Granuloma of the Jaw: Implications of Genetic Analysis of the Lesion for Treatment Concept and Surveillance

Standard

KRAS Mutation in an Implant-associated Peripheral Giant Cell Granuloma of the Jaw: Implications of Genetic Analysis of the Lesion for Treatment Concept and Surveillance. / Friedrich, Reinhard E; Wüsthoff, Falk; Luebke, Andreas M; Kohlrusch, Felix K; Wieland, Ilse; Zenker, Martin; Gosau, Martin.

In: IN VIVO, Vol. 35, No. 2, 25.02.2021, p. 947-953.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Friedrich, RE, Wüsthoff, F, Luebke, AM, Kohlrusch, FK, Wieland, I, Zenker, M & Gosau, M 2021, 'KRAS Mutation in an Implant-associated Peripheral Giant Cell Granuloma of the Jaw: Implications of Genetic Analysis of the Lesion for Treatment Concept and Surveillance', IN VIVO, vol. 35, no. 2, pp. 947-953. https://doi.org/10.21873/invivo.12335

APA

Friedrich, R. E., Wüsthoff, F., Luebke, A. M., Kohlrusch, F. K., Wieland, I., Zenker, M., & Gosau, M. (2021). KRAS Mutation in an Implant-associated Peripheral Giant Cell Granuloma of the Jaw: Implications of Genetic Analysis of the Lesion for Treatment Concept and Surveillance. IN VIVO, 35(2), 947-953. https://doi.org/10.21873/invivo.12335

Vancouver

Friedrich RE, Wüsthoff F, Luebke AM, Kohlrusch FK, Wieland I, Zenker M et al. KRAS Mutation in an Implant-associated Peripheral Giant Cell Granuloma of the Jaw: Implications of Genetic Analysis of the Lesion for Treatment Concept and Surveillance. IN VIVO. 2021 Feb 25;35(2):947-953. https://doi.org/10.21873/invivo.12335

Bibtex

@article{300d982fdddb4baaa7fe9663690daaba,

title = "KRAS Mutation in an Implant-associated Peripheral Giant Cell Granuloma of the Jaw: Implications of Genetic Analysis of the Lesion for Treatment Concept and Surveillance",

abstract = "The aim of this case report was to detail diagnosis and therapy in a case of implant-associated peripheral giant cell granuloma (IA-PGCG) of the jaw. Case Report: The 41-year-old female attended the outpatient clinic for treatment of recurrent mandibular IA-PGCG. The lesion was excised and the defect was closed with a connective tissue graft of the palate. Healing of oral defects was uneventful, and no local recurrence has occurred during a follow-up of 7 months. Genetic examination of the lesion identified a somatic mutation in KRAS. Conclusion: The lesions are assessed as reactive-inflammatory changes in the mucous membrane of the oral cavity. The cause of the lesion is unknown. KRAS mutations are commonly found in various cancer tissues, but also in germline and mosaic RASopathies. Recently, KRAS mutations have been identified in several IA-PGCG. The clinical course of a frequently locally recurring lesion gives rise to the assumption that lesions of this type show characteristics known in benign neoplasms.",

keywords = "Adult, Connective Tissue, Female, Granuloma, Giant Cell/genetics, Humans, Mutation, Neoplasm Recurrence, Local/genetics, Proto-Oncogene Proteins p21(ras)/genetics",

author = "Friedrich, {Reinhard E} and Falk W{\"u}sthoff and Luebke, {Andreas M} and Kohlrusch, {Felix K} and Ilse Wieland and Martin Zenker and Martin Gosau",

year = "2021",

month = feb,

day = "25",

doi = "10.21873/invivo.12335",

language = "English",

volume = "35",

pages = "947--953",

journal = "IN VIVO",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

number = "2",

}

RIS

TY - JOUR

T1 - KRAS Mutation in an Implant-associated Peripheral Giant Cell Granuloma of the Jaw: Implications of Genetic Analysis of the Lesion for Treatment Concept and Surveillance

AU - Friedrich, Reinhard E

AU - Wüsthoff, Falk

AU - Luebke, Andreas M

AU - Kohlrusch, Felix K

AU - Wieland, Ilse

AU - Zenker, Martin

AU - Gosau, Martin

PY - 2021/2/25

Y1 - 2021/2/25

N2 - The aim of this case report was to detail diagnosis and therapy in a case of implant-associated peripheral giant cell granuloma (IA-PGCG) of the jaw. Case Report: The 41-year-old female attended the outpatient clinic for treatment of recurrent mandibular IA-PGCG. The lesion was excised and the defect was closed with a connective tissue graft of the palate. Healing of oral defects was uneventful, and no local recurrence has occurred during a follow-up of 7 months. Genetic examination of the lesion identified a somatic mutation in KRAS. Conclusion: The lesions are assessed as reactive-inflammatory changes in the mucous membrane of the oral cavity. The cause of the lesion is unknown. KRAS mutations are commonly found in various cancer tissues, but also in germline and mosaic RASopathies. Recently, KRAS mutations have been identified in several IA-PGCG. The clinical course of a frequently locally recurring lesion gives rise to the assumption that lesions of this type show characteristics known in benign neoplasms.

AB - The aim of this case report was to detail diagnosis and therapy in a case of implant-associated peripheral giant cell granuloma (IA-PGCG) of the jaw. Case Report: The 41-year-old female attended the outpatient clinic for treatment of recurrent mandibular IA-PGCG. The lesion was excised and the defect was closed with a connective tissue graft of the palate. Healing of oral defects was uneventful, and no local recurrence has occurred during a follow-up of 7 months. Genetic examination of the lesion identified a somatic mutation in KRAS. Conclusion: The lesions are assessed as reactive-inflammatory changes in the mucous membrane of the oral cavity. The cause of the lesion is unknown. KRAS mutations are commonly found in various cancer tissues, but also in germline and mosaic RASopathies. Recently, KRAS mutations have been identified in several IA-PGCG. The clinical course of a frequently locally recurring lesion gives rise to the assumption that lesions of this type show characteristics known in benign neoplasms.

KW - Adult

KW - Connective Tissue

KW - Female

KW - Granuloma, Giant Cell/genetics

KW - Humans

KW - Mutation

KW - Neoplasm Recurrence, Local/genetics

KW - Proto-Oncogene Proteins p21(ras)/genetics

U2 - 10.21873/invivo.12335

DO - 10.21873/invivo.12335

M3 - SCORING: Journal article

C2 - 33622887

VL - 35

SP - 947

EP - 953

JO - IN VIVO

JF - IN VIVO

SN - 0258-851X

IS - 2

ER -