KRAS Mutation in an Implant-associated Peripheral Giant Cell Granuloma of the Jaw: Implications of Genetic Analysis of the Lesion for Treatment Concept and Surveillance
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KRAS Mutation in an Implant-associated Peripheral Giant Cell Granuloma of the Jaw: Implications of Genetic Analysis of the Lesion for Treatment Concept and Surveillance. / Friedrich, Reinhard E; Wüsthoff, Falk; Luebke, Andreas M; Kohlrusch, Felix K; Wieland, Ilse; Zenker, Martin; Gosau, Martin.
in: IN VIVO, Jahrgang 35, Nr. 2, 25.02.2021, S. 947-953.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - KRAS Mutation in an Implant-associated Peripheral Giant Cell Granuloma of the Jaw: Implications of Genetic Analysis of the Lesion for Treatment Concept and Surveillance
AU - Friedrich, Reinhard E
AU - Wüsthoff, Falk
AU - Luebke, Andreas M
AU - Kohlrusch, Felix K
AU - Wieland, Ilse
AU - Zenker, Martin
AU - Gosau, Martin
N1 - Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
PY - 2021/2/25
Y1 - 2021/2/25
N2 - The aim of this case report was to detail diagnosis and therapy in a case of implant-associated peripheral giant cell granuloma (IA-PGCG) of the jaw. Case Report: The 41-year-old female attended the outpatient clinic for treatment of recurrent mandibular IA-PGCG. The lesion was excised and the defect was closed with a connective tissue graft of the palate. Healing of oral defects was uneventful, and no local recurrence has occurred during a follow-up of 7 months. Genetic examination of the lesion identified a somatic mutation in KRAS. Conclusion: The lesions are assessed as reactive-inflammatory changes in the mucous membrane of the oral cavity. The cause of the lesion is unknown. KRAS mutations are commonly found in various cancer tissues, but also in germline and mosaic RASopathies. Recently, KRAS mutations have been identified in several IA-PGCG. The clinical course of a frequently locally recurring lesion gives rise to the assumption that lesions of this type show characteristics known in benign neoplasms.
AB - The aim of this case report was to detail diagnosis and therapy in a case of implant-associated peripheral giant cell granuloma (IA-PGCG) of the jaw. Case Report: The 41-year-old female attended the outpatient clinic for treatment of recurrent mandibular IA-PGCG. The lesion was excised and the defect was closed with a connective tissue graft of the palate. Healing of oral defects was uneventful, and no local recurrence has occurred during a follow-up of 7 months. Genetic examination of the lesion identified a somatic mutation in KRAS. Conclusion: The lesions are assessed as reactive-inflammatory changes in the mucous membrane of the oral cavity. The cause of the lesion is unknown. KRAS mutations are commonly found in various cancer tissues, but also in germline and mosaic RASopathies. Recently, KRAS mutations have been identified in several IA-PGCG. The clinical course of a frequently locally recurring lesion gives rise to the assumption that lesions of this type show characteristics known in benign neoplasms.
KW - Adult
KW - Connective Tissue
KW - Female
KW - Granuloma, Giant Cell/genetics
KW - Humans
KW - Mutation
KW - Neoplasm Recurrence, Local/genetics
KW - Proto-Oncogene Proteins p21(ras)/genetics
U2 - 10.21873/invivo.12335
DO - 10.21873/invivo.12335
M3 - SCORING: Journal article
C2 - 33622887
VL - 35
SP - 947
EP - 953
JO - IN VIVO
JF - IN VIVO
SN - 0258-851X
IS - 2
ER -