K27M midline gliomas display malignant progression by imaging and histology

TY - JOUR

T1 - K27M midline gliomas display malignant progression by imaging and histology

AU - Vettermann, Franziska J

AU - Neumann, Julia E

AU - Suchorska, Bogdana

AU - Bartenstein, Peter

AU - Giese, Armin

AU - Dorostkar, Mario M

AU - Albert, Nathalie L

AU - Schüller, Ulrich

N1 - Letter

PY - 2017/8

Y1 - 2017/8

N2 - K27M midline gliomas are diffuse gliomas that usually occur in children and young adults and arise in midline structures of the brain, the brain stem and the spinal cord. They are defined by point mutations within the chromatin modifiers H3 and are usually associated with a bad clinical outcome [1,2,3]. As such, they are represented as a new separate entity in the new version of the WHO classification for tumors of the central nervous system. Interestingly, these tumors display a huge histological variability [4] and diagnoses currently range from low grade astrocytoma (WHO-grade II) to glioblastoma (WHO-grade IV). This article is protected by copyright. All rights reserved.

AB - K27M midline gliomas are diffuse gliomas that usually occur in children and young adults and arise in midline structures of the brain, the brain stem and the spinal cord. They are defined by point mutations within the chromatin modifiers H3 and are usually associated with a bad clinical outcome [1,2,3]. As such, they are represented as a new separate entity in the new version of the WHO classification for tumors of the central nervous system. Interestingly, these tumors display a huge histological variability [4] and diagnoses currently range from low grade astrocytoma (WHO-grade II) to glioblastoma (WHO-grade IV). This article is protected by copyright. All rights reserved.

U2 - 10.1111/nan.12371

DO - 10.1111/nan.12371

M3 - Other (editorial matter etc.)

C2 - 27997032

VL - 43

SP - 458

EP - 462

JO - NEUROPATH APPL NEURO

JF - NEUROPATH APPL NEURO

SN - 0305-1846

IS - 5

ER -