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Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany

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Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany. / Weisshaar, Elke; Bentz, Philipp; Apfelbacher, Christian; Haufe, Eva; Heinrich, Luise; Heratizadeh, Annice; Abraham, Susanne; Harder, Inken; Kleinheinz, Andreas; Wollenberg, Andreas; Schäkel, Knut; Wiemers, Franca; Ertner, Julia; Augustin, Matthias; Wildberger, Julia; Von Kiedrowski, Ralph; Worm, Margitta; Zink, Alexander; Effendy, Isaak; Asmussen, Andrea; Pawlak, Mario; Sticherling, Michael; Hilgers, Melanie; Handrick, Christiane; Quist, Sven; Schwarz, Beate; Bell, Magnus; Staubach-Renz, Petra; Hong-Weldemann, Sung-Hei; Homey, Bernhard; Brücher, Jens-Joachim; Weidinger, Stephan; Werfel, Thomas; Schmitt, Jochen; TREATgermany study group.

In: ACTA DERM-VENEREOL, Vol. 103, adv00854, 23.01.2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Weisshaar, E, Bentz, P, Apfelbacher, C, Haufe, E, Heinrich, L, Heratizadeh, A, Abraham, S, Harder, I, Kleinheinz, A, Wollenberg, A, Schäkel, K, Wiemers, F, Ertner, J, Augustin, M, Wildberger, J, Von Kiedrowski, R, Worm, M, Zink, A, Effendy, I, Asmussen, A, Pawlak, M, Sticherling, M, Hilgers, M, Handrick, C, Quist, S, Schwarz, B, Bell, M, Staubach-Renz, P, Hong-Weldemann, S-H, Homey, B, Brücher, J-J, Weidinger, S, Werfel, T, Schmitt, J & TREATgermany study group 2023, 'Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany', ACTA DERM-VENEREOL, vol. 103, adv00854. https://doi.org/10.2340/actadv.v103.4426

APA

Weisshaar, E., Bentz, P., Apfelbacher, C., Haufe, E., Heinrich, L., Heratizadeh, A., Abraham, S., Harder, I., Kleinheinz, A., Wollenberg, A., Schäkel, K., Wiemers, F., Ertner, J., Augustin, M., Wildberger, J., Von Kiedrowski, R., Worm, M., Zink, A., Effendy, I., ... TREATgermany study group (2023). Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany. ACTA DERM-VENEREOL, 103, [adv00854]. https://doi.org/10.2340/actadv.v103.4426

Vancouver

Weisshaar E, Bentz P, Apfelbacher C, Haufe E, Heinrich L, Heratizadeh A et al. Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany. ACTA DERM-VENEREOL. 2023 Jan 23;103. adv00854. https://doi.org/10.2340/actadv.v103.4426

Bibtex

@article{1df38cd9ef64470eb8d1d904832132e1,
title = "Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany",
abstract = "TREATgermany is an investigator-initiated prospective disease registry. It investigates physician- and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Dermatitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symptoms (itch, sleep loss, depressive symptoms), therapy courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD > 20. 1,134 atopic dermatitis patients (mean age 41.0 ± 14.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The current analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the previous 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho = 0.44 (0.39-0.48)) and EASI score (rho = 0.41 (0.36-0.46)). A strong correlation was found with self-reported disease severity as PGA (rho = 0.68 (0.65-0.71)), POEM sum score (rho = 0.66 (0.63-0.69)) and dermatological quality of life impairment DLQI (rho = 0.61 (0.57-0.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assessments by the physician.",
keywords = "Female, Humans, Adult, Middle Aged, Male, Dermatitis, Atopic/diagnosis, Quality of Life, Prospective Studies, Severity of Illness Index, Pruritus, Patient Reported Outcome Measures, Registries, Physicians, Eczema",
author = "Elke Weisshaar and Philipp Bentz and Christian Apfelbacher and Eva Haufe and Luise Heinrich and Annice Heratizadeh and Susanne Abraham and Inken Harder and Andreas Kleinheinz and Andreas Wollenberg and Knut Sch{\"a}kel and Franca Wiemers and Julia Ertner and Matthias Augustin and Julia Wildberger and {Von Kiedrowski}, Ralph and Margitta Worm and Alexander Zink and Isaak Effendy and Andrea Asmussen and Mario Pawlak and Michael Sticherling and Melanie Hilgers and Christiane Handrick and Sven Quist and Beate Schwarz and Magnus Bell and Petra Staubach-Renz and Sung-Hei Hong-Weldemann and Bernhard Homey and Jens-Joachim Br{\"u}cher and Stephan Weidinger and Thomas Werfel and Jochen Schmitt and {TREATgermany study group}",
year = "2023",
month = jan,
day = "23",
doi = "10.2340/actadv.v103.4426",
language = "English",
volume = "103",
journal = "ACTA DERM-VENEREOL",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato-Venereologica",

}

RIS

TY - JOUR

T1 - Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany

AU - Weisshaar, Elke

AU - Bentz, Philipp

AU - Apfelbacher, Christian

AU - Haufe, Eva

AU - Heinrich, Luise

AU - Heratizadeh, Annice

AU - Abraham, Susanne

AU - Harder, Inken

AU - Kleinheinz, Andreas

AU - Wollenberg, Andreas

AU - Schäkel, Knut

AU - Wiemers, Franca

AU - Ertner, Julia

AU - Augustin, Matthias

AU - Wildberger, Julia

AU - Von Kiedrowski, Ralph

AU - Worm, Margitta

AU - Zink, Alexander

AU - Effendy, Isaak

AU - Asmussen, Andrea

AU - Pawlak, Mario

AU - Sticherling, Michael

AU - Hilgers, Melanie

AU - Handrick, Christiane

AU - Quist, Sven

AU - Schwarz, Beate

AU - Bell, Magnus

AU - Staubach-Renz, Petra

AU - Hong-Weldemann, Sung-Hei

AU - Homey, Bernhard

AU - Brücher, Jens-Joachim

AU - Weidinger, Stephan

AU - Werfel, Thomas

AU - Schmitt, Jochen

AU - TREATgermany study group

PY - 2023/1/23

Y1 - 2023/1/23

N2 - TREATgermany is an investigator-initiated prospective disease registry. It investigates physician- and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Dermatitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symptoms (itch, sleep loss, depressive symptoms), therapy courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD > 20. 1,134 atopic dermatitis patients (mean age 41.0 ± 14.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The current analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the previous 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho = 0.44 (0.39-0.48)) and EASI score (rho = 0.41 (0.36-0.46)). A strong correlation was found with self-reported disease severity as PGA (rho = 0.68 (0.65-0.71)), POEM sum score (rho = 0.66 (0.63-0.69)) and dermatological quality of life impairment DLQI (rho = 0.61 (0.57-0.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assessments by the physician.

AB - TREATgermany is an investigator-initiated prospective disease registry. It investigates physician- and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Dermatitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symptoms (itch, sleep loss, depressive symptoms), therapy courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD > 20. 1,134 atopic dermatitis patients (mean age 41.0 ± 14.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The current analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the previous 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho = 0.44 (0.39-0.48)) and EASI score (rho = 0.41 (0.36-0.46)). A strong correlation was found with self-reported disease severity as PGA (rho = 0.68 (0.65-0.71)), POEM sum score (rho = 0.66 (0.63-0.69)) and dermatological quality of life impairment DLQI (rho = 0.61 (0.57-0.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assessments by the physician.

KW - Female

KW - Humans

KW - Adult

KW - Middle Aged

KW - Male

KW - Dermatitis, Atopic/diagnosis

KW - Quality of Life

KW - Prospective Studies

KW - Severity of Illness Index

KW - Pruritus

KW - Patient Reported Outcome Measures

KW - Registries

KW - Physicians

KW - Eczema

U2 - 10.2340/actadv.v103.4426

DO - 10.2340/actadv.v103.4426

M3 - SCORING: Journal article

C2 - 36688701

VL - 103

JO - ACTA DERM-VENEREOL

JF - ACTA DERM-VENEREOL

SN - 0001-5555

M1 - adv00854

ER -