Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany
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Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany. / Weisshaar, Elke; Bentz, Philipp; Apfelbacher, Christian; Haufe, Eva; Heinrich, Luise; Heratizadeh, Annice; Abraham, Susanne; Harder, Inken; Kleinheinz, Andreas; Wollenberg, Andreas; Schäkel, Knut; Wiemers, Franca; Ertner, Julia; Augustin, Matthias; Wildberger, Julia; Von Kiedrowski, Ralph; Worm, Margitta; Zink, Alexander; Effendy, Isaak; Asmussen, Andrea; Pawlak, Mario; Sticherling, Michael; Hilgers, Melanie; Handrick, Christiane; Quist, Sven; Schwarz, Beate; Bell, Magnus; Staubach-Renz, Petra; Hong-Weldemann, Sung-Hei; Homey, Bernhard; Brücher, Jens-Joachim; Weidinger, Stephan; Werfel, Thomas; Schmitt, Jochen; TREATgermany study group.
in: ACTA DERM-VENEREOL, Jahrgang 103, adv00854, 23.01.2023.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany
AU - Weisshaar, Elke
AU - Bentz, Philipp
AU - Apfelbacher, Christian
AU - Haufe, Eva
AU - Heinrich, Luise
AU - Heratizadeh, Annice
AU - Abraham, Susanne
AU - Harder, Inken
AU - Kleinheinz, Andreas
AU - Wollenberg, Andreas
AU - Schäkel, Knut
AU - Wiemers, Franca
AU - Ertner, Julia
AU - Augustin, Matthias
AU - Wildberger, Julia
AU - Von Kiedrowski, Ralph
AU - Worm, Margitta
AU - Zink, Alexander
AU - Effendy, Isaak
AU - Asmussen, Andrea
AU - Pawlak, Mario
AU - Sticherling, Michael
AU - Hilgers, Melanie
AU - Handrick, Christiane
AU - Quist, Sven
AU - Schwarz, Beate
AU - Bell, Magnus
AU - Staubach-Renz, Petra
AU - Hong-Weldemann, Sung-Hei
AU - Homey, Bernhard
AU - Brücher, Jens-Joachim
AU - Weidinger, Stephan
AU - Werfel, Thomas
AU - Schmitt, Jochen
AU - TREATgermany study group
PY - 2023/1/23
Y1 - 2023/1/23
N2 - TREATgermany is an investigator-initiated prospective disease registry. It investigates physician- and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Dermatitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symptoms (itch, sleep loss, depressive symptoms), therapy courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD > 20. 1,134 atopic dermatitis patients (mean age 41.0 ± 14.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The current analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the previous 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho = 0.44 (0.39-0.48)) and EASI score (rho = 0.41 (0.36-0.46)). A strong correlation was found with self-reported disease severity as PGA (rho = 0.68 (0.65-0.71)), POEM sum score (rho = 0.66 (0.63-0.69)) and dermatological quality of life impairment DLQI (rho = 0.61 (0.57-0.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assessments by the physician.
AB - TREATgermany is an investigator-initiated prospective disease registry. It investigates physician- and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Dermatitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symptoms (itch, sleep loss, depressive symptoms), therapy courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD > 20. 1,134 atopic dermatitis patients (mean age 41.0 ± 14.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The current analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the previous 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho = 0.44 (0.39-0.48)) and EASI score (rho = 0.41 (0.36-0.46)). A strong correlation was found with self-reported disease severity as PGA (rho = 0.68 (0.65-0.71)), POEM sum score (rho = 0.66 (0.63-0.69)) and dermatological quality of life impairment DLQI (rho = 0.61 (0.57-0.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assessments by the physician.
KW - Female
KW - Humans
KW - Adult
KW - Middle Aged
KW - Male
KW - Dermatitis, Atopic/diagnosis
KW - Quality of Life
KW - Prospective Studies
KW - Severity of Illness Index
KW - Pruritus
KW - Patient Reported Outcome Measures
KW - Registries
KW - Physicians
KW - Eczema
U2 - 10.2340/actadv.v103.4426
DO - 10.2340/actadv.v103.4426
M3 - SCORING: Journal article
C2 - 36688701
VL - 103
JO - ACTA DERM-VENEREOL
JF - ACTA DERM-VENEREOL
SN - 0001-5555
M1 - adv00854
ER -