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Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Can Natural Killer and CD8 T Cells Switch Jobs?

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Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Can Natural Killer and CD8 T Cells Switch Jobs? / Biron, Christine A; Altfeld, Marcus.

In: CSH PERSPECT BIOL, Vol. 10, No. 10, 01.10.2018, p. a029892.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Biron, CA & Altfeld, M 2018, 'Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Can Natural Killer and CD8 T Cells Switch Jobs?', CSH PERSPECT BIOL, vol. 10, no. 10, pp. a029892. https://doi.org/10.1101/cshperspect.a029892

APA

Biron, C. A., & Altfeld, M. (2018). Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Can Natural Killer and CD8 T Cells Switch Jobs? CSH PERSPECT BIOL, 10(10), a029892. https://doi.org/10.1101/cshperspect.a029892

Vancouver

Biron CA, Altfeld M. Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Can Natural Killer and CD8 T Cells Switch Jobs? CSH PERSPECT BIOL. 2018 Oct 1;10(10):a029892. https://doi.org/10.1101/cshperspect.a029892

Bibtex

@article{7867dad73a0747a483e4112a27c8d319,
title = "Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Can Natural Killer and CD8 T Cells Switch Jobs?",
abstract = "Natural killer (NK) cells are components of innate immunity mediating defense at early times after viral infections. Their cytokine production and cell-mediated cytotoxicity functions overlap those of CD8 T cells elicited later during primary adaptive immune responses, but the populations are distinguished by their basal states and activating receptors as well as the kinetics of their responses. Demonstration of long-lived NK cells has led to speculation on the potential for inducing these to contribute to immunological memory. Conversely, activated CD8 T cells can acquire responses to innate cytokines and, as a result, have the potential to contribute to innate immunity. These observations beg the question: what is required to be a player in innate and adaptive immunity?",
keywords = "Animals, CD8-Positive T-Lymphocytes/physiology, Cytotoxicity, Immunologic, Humans, Immunologic Memory, Killer Cells, Natural/physiology, Lymphocyte Activation, Vaccination",
author = "Biron, {Christine A} and Marcus Altfeld",
note = "Copyright {\textcopyright} 2018 Cold Spring Harbor Laboratory Press; all rights reserved.",
year = "2018",
month = oct,
day = "1",
doi = "10.1101/cshperspect.a029892",
language = "English",
volume = "10",
pages = "a029892",
journal = "CSH PERSPECT BIOL",
issn = "1943-0264",
publisher = "Cold Spring Harbor Laboratory Press",
number = "10",

}

RIS

TY - JOUR

T1 - Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Can Natural Killer and CD8 T Cells Switch Jobs?

AU - Biron, Christine A

AU - Altfeld, Marcus

N1 - Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Natural killer (NK) cells are components of innate immunity mediating defense at early times after viral infections. Their cytokine production and cell-mediated cytotoxicity functions overlap those of CD8 T cells elicited later during primary adaptive immune responses, but the populations are distinguished by their basal states and activating receptors as well as the kinetics of their responses. Demonstration of long-lived NK cells has led to speculation on the potential for inducing these to contribute to immunological memory. Conversely, activated CD8 T cells can acquire responses to innate cytokines and, as a result, have the potential to contribute to innate immunity. These observations beg the question: what is required to be a player in innate and adaptive immunity?

AB - Natural killer (NK) cells are components of innate immunity mediating defense at early times after viral infections. Their cytokine production and cell-mediated cytotoxicity functions overlap those of CD8 T cells elicited later during primary adaptive immune responses, but the populations are distinguished by their basal states and activating receptors as well as the kinetics of their responses. Demonstration of long-lived NK cells has led to speculation on the potential for inducing these to contribute to immunological memory. Conversely, activated CD8 T cells can acquire responses to innate cytokines and, as a result, have the potential to contribute to innate immunity. These observations beg the question: what is required to be a player in innate and adaptive immunity?

KW - Animals

KW - CD8-Positive T-Lymphocytes/physiology

KW - Cytotoxicity, Immunologic

KW - Humans

KW - Immunologic Memory

KW - Killer Cells, Natural/physiology

KW - Lymphocyte Activation

KW - Vaccination

U2 - 10.1101/cshperspect.a029892

DO - 10.1101/cshperspect.a029892

M3 - SCORING: Review article

C2 - 29254975

VL - 10

SP - a029892

JO - CSH PERSPECT BIOL

JF - CSH PERSPECT BIOL

SN - 1943-0264

IS - 10

ER -