Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Can Natural Killer and CD8 T Cells Switch Jobs?
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Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Can Natural Killer and CD8 T Cells Switch Jobs? / Biron, Christine A; Altfeld, Marcus.
in: CSH PERSPECT BIOL, Jahrgang 10, Nr. 10, 01.10.2018, S. a029892.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Can Natural Killer and CD8 T Cells Switch Jobs?
AU - Biron, Christine A
AU - Altfeld, Marcus
N1 - Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Natural killer (NK) cells are components of innate immunity mediating defense at early times after viral infections. Their cytokine production and cell-mediated cytotoxicity functions overlap those of CD8 T cells elicited later during primary adaptive immune responses, but the populations are distinguished by their basal states and activating receptors as well as the kinetics of their responses. Demonstration of long-lived NK cells has led to speculation on the potential for inducing these to contribute to immunological memory. Conversely, activated CD8 T cells can acquire responses to innate cytokines and, as a result, have the potential to contribute to innate immunity. These observations beg the question: what is required to be a player in innate and adaptive immunity?
AB - Natural killer (NK) cells are components of innate immunity mediating defense at early times after viral infections. Their cytokine production and cell-mediated cytotoxicity functions overlap those of CD8 T cells elicited later during primary adaptive immune responses, but the populations are distinguished by their basal states and activating receptors as well as the kinetics of their responses. Demonstration of long-lived NK cells has led to speculation on the potential for inducing these to contribute to immunological memory. Conversely, activated CD8 T cells can acquire responses to innate cytokines and, as a result, have the potential to contribute to innate immunity. These observations beg the question: what is required to be a player in innate and adaptive immunity?
KW - Animals
KW - CD8-Positive T-Lymphocytes/physiology
KW - Cytotoxicity, Immunologic
KW - Humans
KW - Immunologic Memory
KW - Killer Cells, Natural/physiology
KW - Lymphocyte Activation
KW - Vaccination
U2 - 10.1101/cshperspect.a029892
DO - 10.1101/cshperspect.a029892
M3 - SCORING: Review article
C2 - 29254975
VL - 10
SP - a029892
JO - CSH PERSPECT BIOL
JF - CSH PERSPECT BIOL
SN - 1943-0264
IS - 10
ER -