Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer
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Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer. / Flammiger, Anna; Bayer, Florian; Cirugeda-Kühnert, Ana; Huland, Hartwig; Tennstedt, Pierre; Simon, Ronald; Minner, Sarah; Bokemeyer, Carsten; Sauter, Guido; Schlomm, Thorsten; Trepel, Martin.
In: APMIS, Vol. 120, No. 11, 11.2012, p. 901-8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer
AU - Flammiger, Anna
AU - Bayer, Florian
AU - Cirugeda-Kühnert, Ana
AU - Huland, Hartwig
AU - Tennstedt, Pierre
AU - Simon, Ronald
AU - Minner, Sarah
AU - Bokemeyer, Carsten
AU - Sauter, Guido
AU - Schlomm, Thorsten
AU - Trepel, Martin
N1 - © 2012 The Authors APMIS © 2012 APMIS.
PY - 2012/11
Y1 - 2012/11
N2 - The number of tumor-infiltrating lymphocytes is functionally important and correlates with clinical outcome in several tumor entities. Herein we explore the impact of the density of T and B lymphocytes in prostate cancer tissue on prostate-specific antigen (PSA) recurrence after prostatectomy in 3261 prostate cancer tissue samples. The number of prostate cancer-infiltrating CD3-positive T cells and CD20-positive B cells per tissue spot in a tissue microarray format was determined by immunohistochemistry and was correlated with clinical and pathological data from the same patient cohort. Patients with very low and very high numbers of CD3-positive T cells per tissue spot had a significantly shorter PSA recurrence-free survival compared to patients with intermediate numbers of T cells (p = 0.0188). Furthermore, a high number of CD3-positive T cells per tissue spot was associated with fusion type prostate cancer identified by ERG expression analysis. The number of CD20-positive B cells per tissue spot was not associated with other clinical and histopathological parameters. This study indicates that the density of T but not B cells plays a functional role in the biology of prostate cancer and may have an impact on clinical outcome in this frequent neoplasia.
AB - The number of tumor-infiltrating lymphocytes is functionally important and correlates with clinical outcome in several tumor entities. Herein we explore the impact of the density of T and B lymphocytes in prostate cancer tissue on prostate-specific antigen (PSA) recurrence after prostatectomy in 3261 prostate cancer tissue samples. The number of prostate cancer-infiltrating CD3-positive T cells and CD20-positive B cells per tissue spot in a tissue microarray format was determined by immunohistochemistry and was correlated with clinical and pathological data from the same patient cohort. Patients with very low and very high numbers of CD3-positive T cells per tissue spot had a significantly shorter PSA recurrence-free survival compared to patients with intermediate numbers of T cells (p = 0.0188). Furthermore, a high number of CD3-positive T cells per tissue spot was associated with fusion type prostate cancer identified by ERG expression analysis. The number of CD20-positive B cells per tissue spot was not associated with other clinical and histopathological parameters. This study indicates that the density of T but not B cells plays a functional role in the biology of prostate cancer and may have an impact on clinical outcome in this frequent neoplasia.
KW - Aged
KW - Antigens, CD20
KW - Antigens, CD3
KW - B-Lymphocytes
KW - Cell Survival
KW - Humans
KW - Immunohistochemistry
KW - Lymphocyte Count
KW - Male
KW - Microarray Analysis
KW - Middle Aged
KW - Proportional Hazards Models
KW - Prostate
KW - Prostate-Specific Antigen
KW - Prostatectomy
KW - Prostatic Neoplasms
KW - Regression Analysis
KW - T-Lymphocytes
KW - Treatment Outcome
KW - Journal Article
U2 - 10.1111/j.1600-0463.2012.02924.x
DO - 10.1111/j.1600-0463.2012.02924.x
M3 - SCORING: Journal article
C2 - 23009114
VL - 120
SP - 901
EP - 908
JO - APMIS
JF - APMIS
SN - 0903-4641
IS - 11
ER -