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Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer

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Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer. / Flammiger, Anna; Bayer, Florian; Cirugeda-Kühnert, Ana; Huland, Hartwig; Tennstedt, Pierre; Simon, Ronald; Minner, Sarah; Bokemeyer, Carsten; Sauter, Guido; Schlomm, Thorsten; Trepel, Martin.

in: APMIS, Jahrgang 120, Nr. 11, 11.2012, S. 901-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Flammiger, A, Bayer, F, Cirugeda-Kühnert, A, Huland, H, Tennstedt, P, Simon, R, Minner, S, Bokemeyer, C, Sauter, G, Schlomm, T & Trepel, M 2012, 'Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer', APMIS, Jg. 120, Nr. 11, S. 901-8. https://doi.org/10.1111/j.1600-0463.2012.02924.x

APA

Flammiger, A., Bayer, F., Cirugeda-Kühnert, A., Huland, H., Tennstedt, P., Simon, R., Minner, S., Bokemeyer, C., Sauter, G., Schlomm, T., & Trepel, M. (2012). Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer. APMIS, 120(11), 901-8. https://doi.org/10.1111/j.1600-0463.2012.02924.x

Vancouver

Flammiger A, Bayer F, Cirugeda-Kühnert A, Huland H, Tennstedt P, Simon R et al. Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer. APMIS. 2012 Nov;120(11):901-8. https://doi.org/10.1111/j.1600-0463.2012.02924.x

Bibtex

@article{871cc81f1087462c8a657ef051dc0259,
title = "Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer",
abstract = "The number of tumor-infiltrating lymphocytes is functionally important and correlates with clinical outcome in several tumor entities. Herein we explore the impact of the density of T and B lymphocytes in prostate cancer tissue on prostate-specific antigen (PSA) recurrence after prostatectomy in 3261 prostate cancer tissue samples. The number of prostate cancer-infiltrating CD3-positive T cells and CD20-positive B cells per tissue spot in a tissue microarray format was determined by immunohistochemistry and was correlated with clinical and pathological data from the same patient cohort. Patients with very low and very high numbers of CD3-positive T cells per tissue spot had a significantly shorter PSA recurrence-free survival compared to patients with intermediate numbers of T cells (p = 0.0188). Furthermore, a high number of CD3-positive T cells per tissue spot was associated with fusion type prostate cancer identified by ERG expression analysis. The number of CD20-positive B cells per tissue spot was not associated with other clinical and histopathological parameters. This study indicates that the density of T but not B cells plays a functional role in the biology of prostate cancer and may have an impact on clinical outcome in this frequent neoplasia.",
keywords = "Aged, Antigens, CD20, Antigens, CD3, B-Lymphocytes, Cell Survival, Humans, Immunohistochemistry, Lymphocyte Count, Male, Microarray Analysis, Middle Aged, Proportional Hazards Models, Prostate, Prostate-Specific Antigen, Prostatectomy, Prostatic Neoplasms, Regression Analysis, T-Lymphocytes, Treatment Outcome, Journal Article",
author = "Anna Flammiger and Florian Bayer and Ana Cirugeda-K{\"u}hnert and Hartwig Huland and Pierre Tennstedt and Ronald Simon and Sarah Minner and Carsten Bokemeyer and Guido Sauter and Thorsten Schlomm and Martin Trepel",
note = "{\textcopyright} 2012 The Authors APMIS {\textcopyright} 2012 APMIS.",
year = "2012",
month = nov,
doi = "10.1111/j.1600-0463.2012.02924.x",
language = "English",
volume = "120",
pages = "901--8",
journal = "APMIS",
issn = "0903-4641",
publisher = "Wiley-Blackwell",
number = "11",

}

RIS

TY - JOUR

T1 - Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer

AU - Flammiger, Anna

AU - Bayer, Florian

AU - Cirugeda-Kühnert, Ana

AU - Huland, Hartwig

AU - Tennstedt, Pierre

AU - Simon, Ronald

AU - Minner, Sarah

AU - Bokemeyer, Carsten

AU - Sauter, Guido

AU - Schlomm, Thorsten

AU - Trepel, Martin

N1 - © 2012 The Authors APMIS © 2012 APMIS.

PY - 2012/11

Y1 - 2012/11

N2 - The number of tumor-infiltrating lymphocytes is functionally important and correlates with clinical outcome in several tumor entities. Herein we explore the impact of the density of T and B lymphocytes in prostate cancer tissue on prostate-specific antigen (PSA) recurrence after prostatectomy in 3261 prostate cancer tissue samples. The number of prostate cancer-infiltrating CD3-positive T cells and CD20-positive B cells per tissue spot in a tissue microarray format was determined by immunohistochemistry and was correlated with clinical and pathological data from the same patient cohort. Patients with very low and very high numbers of CD3-positive T cells per tissue spot had a significantly shorter PSA recurrence-free survival compared to patients with intermediate numbers of T cells (p = 0.0188). Furthermore, a high number of CD3-positive T cells per tissue spot was associated with fusion type prostate cancer identified by ERG expression analysis. The number of CD20-positive B cells per tissue spot was not associated with other clinical and histopathological parameters. This study indicates that the density of T but not B cells plays a functional role in the biology of prostate cancer and may have an impact on clinical outcome in this frequent neoplasia.

AB - The number of tumor-infiltrating lymphocytes is functionally important and correlates with clinical outcome in several tumor entities. Herein we explore the impact of the density of T and B lymphocytes in prostate cancer tissue on prostate-specific antigen (PSA) recurrence after prostatectomy in 3261 prostate cancer tissue samples. The number of prostate cancer-infiltrating CD3-positive T cells and CD20-positive B cells per tissue spot in a tissue microarray format was determined by immunohistochemistry and was correlated with clinical and pathological data from the same patient cohort. Patients with very low and very high numbers of CD3-positive T cells per tissue spot had a significantly shorter PSA recurrence-free survival compared to patients with intermediate numbers of T cells (p = 0.0188). Furthermore, a high number of CD3-positive T cells per tissue spot was associated with fusion type prostate cancer identified by ERG expression analysis. The number of CD20-positive B cells per tissue spot was not associated with other clinical and histopathological parameters. This study indicates that the density of T but not B cells plays a functional role in the biology of prostate cancer and may have an impact on clinical outcome in this frequent neoplasia.

KW - Aged

KW - Antigens, CD20

KW - Antigens, CD3

KW - B-Lymphocytes

KW - Cell Survival

KW - Humans

KW - Immunohistochemistry

KW - Lymphocyte Count

KW - Male

KW - Microarray Analysis

KW - Middle Aged

KW - Proportional Hazards Models

KW - Prostate

KW - Prostate-Specific Antigen

KW - Prostatectomy

KW - Prostatic Neoplasms

KW - Regression Analysis

KW - T-Lymphocytes

KW - Treatment Outcome

KW - Journal Article

U2 - 10.1111/j.1600-0463.2012.02924.x

DO - 10.1111/j.1600-0463.2012.02924.x

M3 - SCORING: Journal article

C2 - 23009114

VL - 120

SP - 901

EP - 908

JO - APMIS

JF - APMIS

SN - 0903-4641

IS - 11

ER -