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Intraindividual comparison of 123I-mIBG SPECT/MRI, 123I-mIBG SPECT/CT, and MRI for the detection of adrenal pheochromocytoma in patients with elevated urine or plasma catecholamines

Standard

Intraindividual comparison of 123I-mIBG SPECT/MRI, 123I-mIBG SPECT/CT, and MRI for the detection of adrenal pheochromocytoma in patients with elevated urine or plasma catecholamines. / Derlin, Thorsten; Busch, Jasmin D; Wisotzki, Christian; Schoennagel, Bjoern P; Bannas, Peter; Papp, László; Klutmann, Susanne; Habermann, Christian R.

In: CLIN NUCL MED, Vol. 38, No. 1, 01.01.2013, p. e1-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Derlin, T, Busch, JD, Wisotzki, C, Schoennagel, BP, Bannas, P, Papp, L, Klutmann, S & Habermann, CR 2013, 'Intraindividual comparison of 123I-mIBG SPECT/MRI, 123I-mIBG SPECT/CT, and MRI for the detection of adrenal pheochromocytoma in patients with elevated urine or plasma catecholamines', CLIN NUCL MED, vol. 38, no. 1, pp. e1-6. https://doi.org/10.1097/RLU.0b013e318263923d

APA

Derlin, T., Busch, J. D., Wisotzki, C., Schoennagel, B. P., Bannas, P., Papp, L., Klutmann, S., & Habermann, C. R. (2013). Intraindividual comparison of 123I-mIBG SPECT/MRI, 123I-mIBG SPECT/CT, and MRI for the detection of adrenal pheochromocytoma in patients with elevated urine or plasma catecholamines. CLIN NUCL MED, 38(1), e1-6. https://doi.org/10.1097/RLU.0b013e318263923d

Vancouver

Derlin T, Busch JD, Wisotzki C, Schoennagel BP, Bannas P, Papp L et al. Intraindividual comparison of 123I-mIBG SPECT/MRI, 123I-mIBG SPECT/CT, and MRI for the detection of adrenal pheochromocytoma in patients with elevated urine or plasma catecholamines. CLIN NUCL MED. 2013 Jan 1;38(1):e1-6. https://doi.org/10.1097/RLU.0b013e318263923d

Bibtex

@article{653cd0d5ec1740c6b4c4bcb06953822c,
title = "Intraindividual comparison of 123I-mIBG SPECT/MRI, 123I-mIBG SPECT/CT, and MRI for the detection of adrenal pheochromocytoma in patients with elevated urine or plasma catecholamines",
abstract = "PURPOSE: To determine the diagnostic performance of ¹²³I-metaiodobenzylguanidine (mIBG) SPECT/MRI fusion, ¹²³I-mIBG SPECT/CT and adrenal MRI for the detection of pheochromocytoma in patients with elevated urine or plasma catecholamines.PATIENTS AND METHODS: Twenty-two consecutive patients underwent both a whole-body ¹²³I-mIBG scan with SPECT/CT of the adrenal region and MRI of the adrenal glands. Fused SPECT/MRI, SPECT/CT, and MRI scans were evaluated. Imaging results were analyzed both on a per-patient and on a per-lesion basis. Histopathology and/or clinical and radiological follow-up served as the reference standard.RESULTS: Sixteen adrenal tumors were found in thirteen patients. On a per-lesion basis, SPECT/CT had a sensitivity of 87.5%, a specificity of 93.8%, and an overall accuracy of 92.5%. MRI had a sensitivity of 87.5%, a specificity of 96.9%, and an overall accuracy of 95.0%. On a per-patient basis, both SPECT/CT and MRI had a sensitivity of 85.7%, a specificity of 93.3%, and an overall accuracy of 90.9%. SPECT/CT was concordant with MRI in 81.8% of cases. SPECT/MRI fusion was superior to both SPECT/CT and MRI and had a sensitivity of 100% on both a per-lesion and a per-patient basis.CONCLUSIONS: ¹²³I-mIBG SPECT/MRI has the highest sensitivity and accuracy for the detection and localization of pheochromocytomas. SPECT/CT and MRI of the adrenal glands are equivalent diagnostic procedures. However, MRI offers the advantage of fully diagnostic assessment of adrenal lesions other than pheochromocytoma undetectable by ¹²³I-mIBG.",
keywords = "3-Iodobenzylguanidine, Adrenal Gland Neoplasms, Adult, Aged, Catecholamines, Female, Humans, Iodine Radioisotopes, Magnetic Resonance Imaging, Male, Middle Aged, Pheochromocytoma, Reproducibility of Results, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed, Young Adult",
author = "Thorsten Derlin and Busch, {Jasmin D} and Christian Wisotzki and Schoennagel, {Bjoern P} and Peter Bannas and L{\'a}szl{\'o} Papp and Susanne Klutmann and Habermann, {Christian R}",
year = "2013",
month = jan,
day = "1",
doi = "10.1097/RLU.0b013e318263923d",
language = "English",
volume = "38",
pages = "e1--6",
journal = "CLIN NUCL MED",
issn = "0363-9762",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Intraindividual comparison of 123I-mIBG SPECT/MRI, 123I-mIBG SPECT/CT, and MRI for the detection of adrenal pheochromocytoma in patients with elevated urine or plasma catecholamines

AU - Derlin, Thorsten

AU - Busch, Jasmin D

AU - Wisotzki, Christian

AU - Schoennagel, Bjoern P

AU - Bannas, Peter

AU - Papp, László

AU - Klutmann, Susanne

AU - Habermann, Christian R

PY - 2013/1/1

Y1 - 2013/1/1

N2 - PURPOSE: To determine the diagnostic performance of ¹²³I-metaiodobenzylguanidine (mIBG) SPECT/MRI fusion, ¹²³I-mIBG SPECT/CT and adrenal MRI for the detection of pheochromocytoma in patients with elevated urine or plasma catecholamines.PATIENTS AND METHODS: Twenty-two consecutive patients underwent both a whole-body ¹²³I-mIBG scan with SPECT/CT of the adrenal region and MRI of the adrenal glands. Fused SPECT/MRI, SPECT/CT, and MRI scans were evaluated. Imaging results were analyzed both on a per-patient and on a per-lesion basis. Histopathology and/or clinical and radiological follow-up served as the reference standard.RESULTS: Sixteen adrenal tumors were found in thirteen patients. On a per-lesion basis, SPECT/CT had a sensitivity of 87.5%, a specificity of 93.8%, and an overall accuracy of 92.5%. MRI had a sensitivity of 87.5%, a specificity of 96.9%, and an overall accuracy of 95.0%. On a per-patient basis, both SPECT/CT and MRI had a sensitivity of 85.7%, a specificity of 93.3%, and an overall accuracy of 90.9%. SPECT/CT was concordant with MRI in 81.8% of cases. SPECT/MRI fusion was superior to both SPECT/CT and MRI and had a sensitivity of 100% on both a per-lesion and a per-patient basis.CONCLUSIONS: ¹²³I-mIBG SPECT/MRI has the highest sensitivity and accuracy for the detection and localization of pheochromocytomas. SPECT/CT and MRI of the adrenal glands are equivalent diagnostic procedures. However, MRI offers the advantage of fully diagnostic assessment of adrenal lesions other than pheochromocytoma undetectable by ¹²³I-mIBG.

AB - PURPOSE: To determine the diagnostic performance of ¹²³I-metaiodobenzylguanidine (mIBG) SPECT/MRI fusion, ¹²³I-mIBG SPECT/CT and adrenal MRI for the detection of pheochromocytoma in patients with elevated urine or plasma catecholamines.PATIENTS AND METHODS: Twenty-two consecutive patients underwent both a whole-body ¹²³I-mIBG scan with SPECT/CT of the adrenal region and MRI of the adrenal glands. Fused SPECT/MRI, SPECT/CT, and MRI scans were evaluated. Imaging results were analyzed both on a per-patient and on a per-lesion basis. Histopathology and/or clinical and radiological follow-up served as the reference standard.RESULTS: Sixteen adrenal tumors were found in thirteen patients. On a per-lesion basis, SPECT/CT had a sensitivity of 87.5%, a specificity of 93.8%, and an overall accuracy of 92.5%. MRI had a sensitivity of 87.5%, a specificity of 96.9%, and an overall accuracy of 95.0%. On a per-patient basis, both SPECT/CT and MRI had a sensitivity of 85.7%, a specificity of 93.3%, and an overall accuracy of 90.9%. SPECT/CT was concordant with MRI in 81.8% of cases. SPECT/MRI fusion was superior to both SPECT/CT and MRI and had a sensitivity of 100% on both a per-lesion and a per-patient basis.CONCLUSIONS: ¹²³I-mIBG SPECT/MRI has the highest sensitivity and accuracy for the detection and localization of pheochromocytomas. SPECT/CT and MRI of the adrenal glands are equivalent diagnostic procedures. However, MRI offers the advantage of fully diagnostic assessment of adrenal lesions other than pheochromocytoma undetectable by ¹²³I-mIBG.

KW - 3-Iodobenzylguanidine

KW - Adrenal Gland Neoplasms

KW - Adult

KW - Aged

KW - Catecholamines

KW - Female

KW - Humans

KW - Iodine Radioisotopes

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Pheochromocytoma

KW - Reproducibility of Results

KW - Tomography, Emission-Computed, Single-Photon

KW - Tomography, X-Ray Computed

KW - Young Adult

U2 - 10.1097/RLU.0b013e318263923d

DO - 10.1097/RLU.0b013e318263923d

M3 - SCORING: Journal article

C2 - 22996238

VL - 38

SP - e1-6

JO - CLIN NUCL MED

JF - CLIN NUCL MED

SN - 0363-9762

IS - 1

ER -