Intraindividual comparison of 123I-mIBG SPECT/MRI, 123I-mIBG SPECT/CT, and MRI for the detection of adrenal pheochromocytoma in patients with elevated urine or plasma catecholamines
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Intraindividual comparison of 123I-mIBG SPECT/MRI, 123I-mIBG SPECT/CT, and MRI for the detection of adrenal pheochromocytoma in patients with elevated urine or plasma catecholamines. / Derlin, Thorsten; Busch, Jasmin D; Wisotzki, Christian; Schoennagel, Bjoern P; Bannas, Peter; Papp, László; Klutmann, Susanne; Habermann, Christian R.
in: CLIN NUCL MED, Jahrgang 38, Nr. 1, 01.01.2013, S. e1-6.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Intraindividual comparison of 123I-mIBG SPECT/MRI, 123I-mIBG SPECT/CT, and MRI for the detection of adrenal pheochromocytoma in patients with elevated urine or plasma catecholamines
AU - Derlin, Thorsten
AU - Busch, Jasmin D
AU - Wisotzki, Christian
AU - Schoennagel, Bjoern P
AU - Bannas, Peter
AU - Papp, László
AU - Klutmann, Susanne
AU - Habermann, Christian R
PY - 2013/1/1
Y1 - 2013/1/1
N2 - PURPOSE: To determine the diagnostic performance of ¹²³I-metaiodobenzylguanidine (mIBG) SPECT/MRI fusion, ¹²³I-mIBG SPECT/CT and adrenal MRI for the detection of pheochromocytoma in patients with elevated urine or plasma catecholamines.PATIENTS AND METHODS: Twenty-two consecutive patients underwent both a whole-body ¹²³I-mIBG scan with SPECT/CT of the adrenal region and MRI of the adrenal glands. Fused SPECT/MRI, SPECT/CT, and MRI scans were evaluated. Imaging results were analyzed both on a per-patient and on a per-lesion basis. Histopathology and/or clinical and radiological follow-up served as the reference standard.RESULTS: Sixteen adrenal tumors were found in thirteen patients. On a per-lesion basis, SPECT/CT had a sensitivity of 87.5%, a specificity of 93.8%, and an overall accuracy of 92.5%. MRI had a sensitivity of 87.5%, a specificity of 96.9%, and an overall accuracy of 95.0%. On a per-patient basis, both SPECT/CT and MRI had a sensitivity of 85.7%, a specificity of 93.3%, and an overall accuracy of 90.9%. SPECT/CT was concordant with MRI in 81.8% of cases. SPECT/MRI fusion was superior to both SPECT/CT and MRI and had a sensitivity of 100% on both a per-lesion and a per-patient basis.CONCLUSIONS: ¹²³I-mIBG SPECT/MRI has the highest sensitivity and accuracy for the detection and localization of pheochromocytomas. SPECT/CT and MRI of the adrenal glands are equivalent diagnostic procedures. However, MRI offers the advantage of fully diagnostic assessment of adrenal lesions other than pheochromocytoma undetectable by ¹²³I-mIBG.
AB - PURPOSE: To determine the diagnostic performance of ¹²³I-metaiodobenzylguanidine (mIBG) SPECT/MRI fusion, ¹²³I-mIBG SPECT/CT and adrenal MRI for the detection of pheochromocytoma in patients with elevated urine or plasma catecholamines.PATIENTS AND METHODS: Twenty-two consecutive patients underwent both a whole-body ¹²³I-mIBG scan with SPECT/CT of the adrenal region and MRI of the adrenal glands. Fused SPECT/MRI, SPECT/CT, and MRI scans were evaluated. Imaging results were analyzed both on a per-patient and on a per-lesion basis. Histopathology and/or clinical and radiological follow-up served as the reference standard.RESULTS: Sixteen adrenal tumors were found in thirteen patients. On a per-lesion basis, SPECT/CT had a sensitivity of 87.5%, a specificity of 93.8%, and an overall accuracy of 92.5%. MRI had a sensitivity of 87.5%, a specificity of 96.9%, and an overall accuracy of 95.0%. On a per-patient basis, both SPECT/CT and MRI had a sensitivity of 85.7%, a specificity of 93.3%, and an overall accuracy of 90.9%. SPECT/CT was concordant with MRI in 81.8% of cases. SPECT/MRI fusion was superior to both SPECT/CT and MRI and had a sensitivity of 100% on both a per-lesion and a per-patient basis.CONCLUSIONS: ¹²³I-mIBG SPECT/MRI has the highest sensitivity and accuracy for the detection and localization of pheochromocytomas. SPECT/CT and MRI of the adrenal glands are equivalent diagnostic procedures. However, MRI offers the advantage of fully diagnostic assessment of adrenal lesions other than pheochromocytoma undetectable by ¹²³I-mIBG.
KW - 3-Iodobenzylguanidine
KW - Adrenal Gland Neoplasms
KW - Adult
KW - Aged
KW - Catecholamines
KW - Female
KW - Humans
KW - Iodine Radioisotopes
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Pheochromocytoma
KW - Reproducibility of Results
KW - Tomography, Emission-Computed, Single-Photon
KW - Tomography, X-Ray Computed
KW - Young Adult
U2 - 10.1097/RLU.0b013e318263923d
DO - 10.1097/RLU.0b013e318263923d
M3 - SCORING: Journal article
C2 - 22996238
VL - 38
SP - e1-6
JO - CLIN NUCL MED
JF - CLIN NUCL MED
SN - 0363-9762
IS - 1
ER -