Research ExplorerPublicationsInteractions Between KIR3DS1 and HLA-F Activate Natural Kill...

Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture

Standard

Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture. / Lunemann, Sebastian; Schöbel, Anja; Kah, Janine; Fittje, Pia; Hölzemer, Angelique; Langeneckert, Annika E; Hess, Leonard U; Poch, Tobias; Martrus, Gloria; Garcia-Beltran, Wilfredo F; Körner, Christian; Ziegler, Annerose E; Richert, Laura; Oldhafer, Karl J; Schulze Zur Wiesch, Julian; Schramm, Christoph; Dandri, Maura; Herker, Eva; Altfeld, Marcus.

In: GASTROENTEROLOGY, Vol. 155, No. 5, 11.2018, p. 1366-1371.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lunemann, S, Schöbel, A, Kah, J, Fittje, P, Hölzemer, A, Langeneckert, AE, Hess, LU, Poch, T, Martrus, G, Garcia-Beltran, WF, Körner, C, Ziegler, AE, Richert, L, Oldhafer, KJ, Schulze Zur Wiesch, J, Schramm, C, Dandri, M, Herker, E & Altfeld, M 2018, 'Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture', GASTROENTEROLOGY, vol. 155, no. 5, pp. 1366-1371. https://doi.org/10.1053/j.gastro.2018.07.019

APA

Lunemann, S., Schöbel, A., Kah, J., Fittje, P., Hölzemer, A., Langeneckert, A. E., Hess, L. U., Poch, T., Martrus, G., Garcia-Beltran, W. F., Körner, C., Ziegler, A. E., Richert, L., Oldhafer, K. J., Schulze Zur Wiesch, J., Schramm, C., Dandri, M., Herker, E., & Altfeld, M. (2018). Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture. GASTROENTEROLOGY, 155(5), 1366-1371. https://doi.org/10.1053/j.gastro.2018.07.019

Vancouver

Lunemann S, Schöbel A, Kah J, Fittje P, Hölzemer A, Langeneckert AE et al. Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture. GASTROENTEROLOGY. 2018 Nov;155(5):1366-1371. https://doi.org/10.1053/j.gastro.2018.07.019

Bibtex

@article{d6415da0aa1d49a080e1c75da372602b,
title = "Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture",
abstract = "Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers, and primary liver tissue from HCV-infected individuals, we found that the KIR3DS1 ligand HLA-F is up-regulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer.",
keywords = "Cells, Cultured, Hepacivirus, Hepatitis C, Histocompatibility Antigens Class I, Humans, Killer Cells, Natural, Lymphocyte Activation, Receptors, KIR3DS1, Virus Replication, Journal Article, Research Support, Non-U.S. Gov't",
author = "Sebastian Lunemann and Anja Sch{\"o}bel and Janine Kah and Pia Fittje and Angelique H{\"o}lzemer and Langeneckert, {Annika E} and Hess, {Leonard U} and Tobias Poch and Gloria Martrus and Garcia-Beltran, {Wilfredo F} and Christian K{\"o}rner and Ziegler, {Annerose E} and Laura Richert and Oldhafer, {Karl J} and {Schulze Zur Wiesch}, Julian and Christoph Schramm and Maura Dandri and Eva Herker and Marcus Altfeld",
note = "Copyright {\textcopyright} 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = nov,
doi = "10.1053/j.gastro.2018.07.019",
language = "English",
volume = "155",
pages = "1366--1371",
journal = "GASTROENTEROLOGY",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture

AU - Lunemann, Sebastian

AU - Schöbel, Anja

AU - Kah, Janine

AU - Fittje, Pia

AU - Hölzemer, Angelique

AU - Langeneckert, Annika E

AU - Hess, Leonard U

AU - Poch, Tobias

AU - Martrus, Gloria

AU - Garcia-Beltran, Wilfredo F

AU - Körner, Christian

AU - Ziegler, Annerose E

AU - Richert, Laura

AU - Oldhafer, Karl J

AU - Schulze Zur Wiesch, Julian

AU - Schramm, Christoph

AU - Dandri, Maura

AU - Herker, Eva

AU - Altfeld, Marcus

N1 - Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

PY - 2018/11

Y1 - 2018/11

N2 - Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers, and primary liver tissue from HCV-infected individuals, we found that the KIR3DS1 ligand HLA-F is up-regulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer.

AB - Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers, and primary liver tissue from HCV-infected individuals, we found that the KIR3DS1 ligand HLA-F is up-regulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer.

KW - Cells, Cultured

KW - Hepacivirus

KW - Hepatitis C

KW - Histocompatibility Antigens Class I

KW - Humans

KW - Killer Cells, Natural

KW - Lymphocyte Activation

KW - Receptors, KIR3DS1

KW - Virus Replication

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1053/j.gastro.2018.07.019

DO - 10.1053/j.gastro.2018.07.019

M3 - SCORING: Journal article

C2 - 30031767

VL - 155

SP - 1366

EP - 1371

JO - GASTROENTEROLOGY

JF - GASTROENTEROLOGY

SN - 0016-5085

IS - 5

ER -