Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture
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Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture. / Lunemann, Sebastian; Schöbel, Anja; Kah, Janine; Fittje, Pia; Hölzemer, Angelique; Langeneckert, Annika E; Hess, Leonard U; Poch, Tobias; Martrus, Gloria; Garcia-Beltran, Wilfredo F; Körner, Christian; Ziegler, Annerose E; Richert, Laura; Oldhafer, Karl J; Schulze Zur Wiesch, Julian; Schramm, Christoph; Dandri, Maura; Herker, Eva; Altfeld, Marcus.
in: GASTROENTEROLOGY, Jahrgang 155, Nr. 5, 11.2018, S. 1366-1371.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture
AU - Lunemann, Sebastian
AU - Schöbel, Anja
AU - Kah, Janine
AU - Fittje, Pia
AU - Hölzemer, Angelique
AU - Langeneckert, Annika E
AU - Hess, Leonard U
AU - Poch, Tobias
AU - Martrus, Gloria
AU - Garcia-Beltran, Wilfredo F
AU - Körner, Christian
AU - Ziegler, Annerose E
AU - Richert, Laura
AU - Oldhafer, Karl J
AU - Schulze Zur Wiesch, Julian
AU - Schramm, Christoph
AU - Dandri, Maura
AU - Herker, Eva
AU - Altfeld, Marcus
N1 - Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.
PY - 2018/11
Y1 - 2018/11
N2 - Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers, and primary liver tissue from HCV-infected individuals, we found that the KIR3DS1 ligand HLA-F is up-regulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer.
AB - Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers, and primary liver tissue from HCV-infected individuals, we found that the KIR3DS1 ligand HLA-F is up-regulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer.
KW - Cells, Cultured
KW - Hepacivirus
KW - Hepatitis C
KW - Histocompatibility Antigens Class I
KW - Humans
KW - Killer Cells, Natural
KW - Lymphocyte Activation
KW - Receptors, KIR3DS1
KW - Virus Replication
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1053/j.gastro.2018.07.019
DO - 10.1053/j.gastro.2018.07.019
M3 - SCORING: Journal article
C2 - 30031767
VL - 155
SP - 1366
EP - 1371
JO - GASTROENTEROLOGY
JF - GASTROENTEROLOGY
SN - 0016-5085
IS - 5
ER -