Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia
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Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia. / Tinnermann, A; Geuter, S; Sprenger, C; Finsterbusch, J; Büchel, C.
In: SCIENCE, Vol. 358, No. 6359, 06.10.2017, p. 105-108.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia
AU - Tinnermann, A
AU - Geuter, S
AU - Sprenger, C
AU - Finsterbusch, J
AU - Büchel, C
N1 - Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
PY - 2017/10/6
Y1 - 2017/10/6
N2 - Value information about a drug, such as the price tag, can strongly affect its therapeutic effect. We discovered that value information influences adverse treatment outcomes in humans even in the absence of an active substance. Labeling an inert treatment as expensive medication led to stronger nocebo hyperalgesia than labeling it as cheap medication. This effect was mediated by neural interactions between cortex, brainstem, and spinal cord. In particular, activity in the prefrontal cortex mediated the effect of value on nocebo hyperalgesia. Value furthermore modulated coupling between prefrontal areas, brainstem, and spinal cord, which might represent a flexible mechanism through which higher-cognitive representations, such as value, can modulate early pain processing.
AB - Value information about a drug, such as the price tag, can strongly affect its therapeutic effect. We discovered that value information influences adverse treatment outcomes in humans even in the absence of an active substance. Labeling an inert treatment as expensive medication led to stronger nocebo hyperalgesia than labeling it as cheap medication. This effect was mediated by neural interactions between cortex, brainstem, and spinal cord. In particular, activity in the prefrontal cortex mediated the effect of value on nocebo hyperalgesia. Value furthermore modulated coupling between prefrontal areas, brainstem, and spinal cord, which might represent a flexible mechanism through which higher-cognitive representations, such as value, can modulate early pain processing.
KW - Adult
KW - Brain Stem
KW - Drug-Related Side Effects and Adverse Reactions
KW - Female
KW - Functional Neuroimaging
KW - Humans
KW - Hyperalgesia
KW - Male
KW - Nocebo Effect
KW - Pain Measurement
KW - Pain Perception
KW - Pharmaceutical Preparations
KW - Placebos
KW - Prefrontal Cortex
KW - Skin Cream
KW - Spinal Cord
KW - Young Adult
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1126/science.aan1221
DO - 10.1126/science.aan1221
M3 - SCORING: Journal article
C2 - 28983051
VL - 358
SP - 105
EP - 108
JO - SCIENCE
JF - SCIENCE
SN - 0036-8075
IS - 6359
ER -