Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia

A Tinnermann; S Geuter; C Sprenger; J Finsterbusch; C Büchel

doi:10.1126/science.aan1221

Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia

Standard

Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia. / Tinnermann, A; Geuter, S; Sprenger, C ; Finsterbusch, J ; Büchel, C.

in: SCIENCE, Jahrgang 358, Nr. 6359, 06.10.2017, S. 105-108.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tinnermann, A, Geuter, S, Sprenger, C , Finsterbusch, J & Büchel, C 2017, 'Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia', SCIENCE, Jg. 358, Nr. 6359, S. 105-108. https://doi.org/10.1126/science.aan1221

APA

Tinnermann, A., Geuter, S., Sprenger, C., Finsterbusch, J., & Büchel, C. (2017). Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia. SCIENCE, 358(6359), 105-108. https://doi.org/10.1126/science.aan1221

Vancouver

Tinnermann A, Geuter S, Sprenger C , Finsterbusch J , Büchel C. Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia. SCIENCE. 2017 Okt 6;358(6359):105-108. https://doi.org/10.1126/science.aan1221

Bibtex

@article{024dbbe50c2c4ea3bc6c812aab176169,

title = "Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia",

abstract = "Value information about a drug, such as the price tag, can strongly affect its therapeutic effect. We discovered that value information influences adverse treatment outcomes in humans even in the absence of an active substance. Labeling an inert treatment as expensive medication led to stronger nocebo hyperalgesia than labeling it as cheap medication. This effect was mediated by neural interactions between cortex, brainstem, and spinal cord. In particular, activity in the prefrontal cortex mediated the effect of value on nocebo hyperalgesia. Value furthermore modulated coupling between prefrontal areas, brainstem, and spinal cord, which might represent a flexible mechanism through which higher-cognitive representations, such as value, can modulate early pain processing.",

keywords = "Adult, Brain Stem, Drug-Related Side Effects and Adverse Reactions, Female, Functional Neuroimaging, Humans, Hyperalgesia, Male, Nocebo Effect, Pain Measurement, Pain Perception, Pharmaceutical Preparations, Placebos, Prefrontal Cortex, Skin Cream, Spinal Cord, Young Adult, Journal Article, Research Support, Non-U.S. Gov't",

author = "A Tinnermann and S Geuter and C Sprenger and J Finsterbusch and C B{\"u}chel",

note = "Copyright {\textcopyright} 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",

year = "2017",

month = oct,

day = "6",

doi = "10.1126/science.aan1221",

language = "English",

volume = "358",

pages = "105--108",

journal = "SCIENCE",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6359",

}

RIS

TY - JOUR

T1 - Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia

AU - Tinnermann, A

AU - Geuter, S

AU - Sprenger, C

AU - Finsterbusch, J

AU - Büchel, C

PY - 2017/10/6

Y1 - 2017/10/6

N2 - Value information about a drug, such as the price tag, can strongly affect its therapeutic effect. We discovered that value information influences adverse treatment outcomes in humans even in the absence of an active substance. Labeling an inert treatment as expensive medication led to stronger nocebo hyperalgesia than labeling it as cheap medication. This effect was mediated by neural interactions between cortex, brainstem, and spinal cord. In particular, activity in the prefrontal cortex mediated the effect of value on nocebo hyperalgesia. Value furthermore modulated coupling between prefrontal areas, brainstem, and spinal cord, which might represent a flexible mechanism through which higher-cognitive representations, such as value, can modulate early pain processing.

AB - Value information about a drug, such as the price tag, can strongly affect its therapeutic effect. We discovered that value information influences adverse treatment outcomes in humans even in the absence of an active substance. Labeling an inert treatment as expensive medication led to stronger nocebo hyperalgesia than labeling it as cheap medication. This effect was mediated by neural interactions between cortex, brainstem, and spinal cord. In particular, activity in the prefrontal cortex mediated the effect of value on nocebo hyperalgesia. Value furthermore modulated coupling between prefrontal areas, brainstem, and spinal cord, which might represent a flexible mechanism through which higher-cognitive representations, such as value, can modulate early pain processing.

KW - Adult

KW - Brain Stem

KW - Drug-Related Side Effects and Adverse Reactions

KW - Female

KW - Functional Neuroimaging

KW - Humans

KW - Hyperalgesia

KW - Male

KW - Nocebo Effect

KW - Pain Measurement

KW - Pain Perception

KW - Pharmaceutical Preparations

KW - Placebos

KW - Prefrontal Cortex

KW - Skin Cream

KW - Spinal Cord

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1126/science.aan1221

DO - 10.1126/science.aan1221

M3 - SCORING: Journal article

C2 - 28983051

VL - 358

SP - 105

EP - 108

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 6359

ER -