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Interaction of the TGGCA-binding protein with upstream sequences is required for efficient transcription of mouse mammary tumor virus

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Interaction of the TGGCA-binding protein with upstream sequences is required for efficient transcription of mouse mammary tumor virus. / Miksicek, R; Borgmeyer, U; Nowock, J.

In: EMBO J, Vol. 6, No. 5, 05.1987, p. 1355-60.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Miksicek, R, Borgmeyer, U & Nowock, J 1987, 'Interaction of the TGGCA-binding protein with upstream sequences is required for efficient transcription of mouse mammary tumor virus', EMBO J, vol. 6, no. 5, pp. 1355-60.

APA

Miksicek, R., Borgmeyer, U., & Nowock, J. (1987). Interaction of the TGGCA-binding protein with upstream sequences is required for efficient transcription of mouse mammary tumor virus. EMBO J, 6(5), 1355-60.

Vancouver

Miksicek R, Borgmeyer U, Nowock J. Interaction of the TGGCA-binding protein with upstream sequences is required for efficient transcription of mouse mammary tumor virus. EMBO J. 1987 May;6(5):1355-60.

Bibtex

@article{32faa9bce09d4d22b46d0a8e7349388c,
title = "Interaction of the TGGCA-binding protein with upstream sequences is required for efficient transcription of mouse mammary tumor virus",
abstract = "A high-affinity binding site for the TGGCA-binding protein, also known as nuclear factor I, has previously been shown to reside within the mouse mammary tumor virus (MMTV) long terminal repeat. We have introduced mutations into this binding site to test the importance of this ubiquitous nuclear protein in MMTV transcription. Mutations which abolish the binding of the TGGCA protein in vitro are shown to impair strongly glucocorticoid-induced transcription from this promoter in vivo. These data demonstrate that the TGGCA-binding protein is a multifunctional DNA-binding protein, capable of serving a transcriptional role in the case of MMTV, in addition to its known involvement in the replication of adenovirus.",
keywords = "Animals, Base Sequence, CCAAT-Enhancer-Binding Proteins, Cell Line, Cell Nucleus, DNA-Binding Proteins, Genes, Viral, Humans, Liver, Mammary Tumor Virus, Mouse, Mice, NFI Transcription Factors, Nuclear Proteins, Protein Binding, Proto-Oncogenes, Transcription Factors, Transcription, Genetic, Y-Box-Binding Protein 1",
author = "R Miksicek and U Borgmeyer and J Nowock",
year = "1987",
month = may,
language = "English",
volume = "6",
pages = "1355--60",
journal = "EMBO J",
issn = "0261-4189",
publisher = "NATURE PUBLISHING GROUP",
number = "5",

}

RIS

TY - JOUR

T1 - Interaction of the TGGCA-binding protein with upstream sequences is required for efficient transcription of mouse mammary tumor virus

AU - Miksicek, R

AU - Borgmeyer, U

AU - Nowock, J

PY - 1987/5

Y1 - 1987/5

N2 - A high-affinity binding site for the TGGCA-binding protein, also known as nuclear factor I, has previously been shown to reside within the mouse mammary tumor virus (MMTV) long terminal repeat. We have introduced mutations into this binding site to test the importance of this ubiquitous nuclear protein in MMTV transcription. Mutations which abolish the binding of the TGGCA protein in vitro are shown to impair strongly glucocorticoid-induced transcription from this promoter in vivo. These data demonstrate that the TGGCA-binding protein is a multifunctional DNA-binding protein, capable of serving a transcriptional role in the case of MMTV, in addition to its known involvement in the replication of adenovirus.

AB - A high-affinity binding site for the TGGCA-binding protein, also known as nuclear factor I, has previously been shown to reside within the mouse mammary tumor virus (MMTV) long terminal repeat. We have introduced mutations into this binding site to test the importance of this ubiquitous nuclear protein in MMTV transcription. Mutations which abolish the binding of the TGGCA protein in vitro are shown to impair strongly glucocorticoid-induced transcription from this promoter in vivo. These data demonstrate that the TGGCA-binding protein is a multifunctional DNA-binding protein, capable of serving a transcriptional role in the case of MMTV, in addition to its known involvement in the replication of adenovirus.

KW - Animals

KW - Base Sequence

KW - CCAAT-Enhancer-Binding Proteins

KW - Cell Line

KW - Cell Nucleus

KW - DNA-Binding Proteins

KW - Genes, Viral

KW - Humans

KW - Liver

KW - Mammary Tumor Virus, Mouse

KW - Mice

KW - NFI Transcription Factors

KW - Nuclear Proteins

KW - Protein Binding

KW - Proto-Oncogenes

KW - Transcription Factors

KW - Transcription, Genetic

KW - Y-Box-Binding Protein 1

M3 - SCORING: Journal article

C2 - 3038519

VL - 6

SP - 1355

EP - 1360

JO - EMBO J

JF - EMBO J

SN - 0261-4189

IS - 5

ER -