Interaction of brain somatostatin receptors with the PDZ domains of PSD-95.

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Interaction of brain somatostatin receptors with the PDZ domains of PSD-95. / Christenn, Marcus; Kindler, Stefan; Schulz, Stefan; Buck, Friedrich; Richter, Dietmar; Kreienkamp, Hans-Jürgen.

In: FEBS LETT, Vol. 581, No. 27, 27, 2007, p. 5173-5177.

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@article{68986c4d052f4e41b2b1188bdfbe8583,
title = "Interaction of brain somatostatin receptors with the PDZ domains of PSD-95.",
abstract = "Using peptide affinity purification, we identified an interaction between somatostatin receptors SSTR4 and SSTR1 and PDZ domains 1 and 2 of the postsynaptic proteins postsynaptic density protein of 95kDa (PSD-95) and PSD-93. The existence of the SSTR4/PSD-95 complex was verified by coimmunoprecipitation from transfected cells and solubilized brain membranes. In neurons, dendritically localized SSTR4 partially colocalizes with postsynaptic PSD-95. As functional parameters of the receptor, such as coupling to potassium channels, are not affected by the interaction with PSD-95, the association may serve to localize the receptor to postsynaptic sites.",
author = "Marcus Christenn and Stefan Kindler and Stefan Schulz and Friedrich Buck and Dietmar Richter and Hans-J{\"u}rgen Kreienkamp",
year = "2007",
language = "Deutsch",
volume = "581",
pages = "5173--5177",
journal = "FEBS LETT",
issn = "0014-5793",
publisher = "Elsevier",
number = "27",

}

RIS

TY - JOUR

T1 - Interaction of brain somatostatin receptors with the PDZ domains of PSD-95.

AU - Christenn, Marcus

AU - Kindler, Stefan

AU - Schulz, Stefan

AU - Buck, Friedrich

AU - Richter, Dietmar

AU - Kreienkamp, Hans-Jürgen

PY - 2007

Y1 - 2007

N2 - Using peptide affinity purification, we identified an interaction between somatostatin receptors SSTR4 and SSTR1 and PDZ domains 1 and 2 of the postsynaptic proteins postsynaptic density protein of 95kDa (PSD-95) and PSD-93. The existence of the SSTR4/PSD-95 complex was verified by coimmunoprecipitation from transfected cells and solubilized brain membranes. In neurons, dendritically localized SSTR4 partially colocalizes with postsynaptic PSD-95. As functional parameters of the receptor, such as coupling to potassium channels, are not affected by the interaction with PSD-95, the association may serve to localize the receptor to postsynaptic sites.

AB - Using peptide affinity purification, we identified an interaction between somatostatin receptors SSTR4 and SSTR1 and PDZ domains 1 and 2 of the postsynaptic proteins postsynaptic density protein of 95kDa (PSD-95) and PSD-93. The existence of the SSTR4/PSD-95 complex was verified by coimmunoprecipitation from transfected cells and solubilized brain membranes. In neurons, dendritically localized SSTR4 partially colocalizes with postsynaptic PSD-95. As functional parameters of the receptor, such as coupling to potassium channels, are not affected by the interaction with PSD-95, the association may serve to localize the receptor to postsynaptic sites.

M3 - SCORING: Zeitschriftenaufsatz

VL - 581

SP - 5173

EP - 5177

JO - FEBS LETT

JF - FEBS LETT

SN - 0014-5793

IS - 27

M1 - 27

ER -