Interaction of brain somatostatin receptors with the PDZ domains of PSD-95.
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Interaction of brain somatostatin receptors with the PDZ domains of PSD-95. / Christenn, Marcus; Kindler, Stefan; Schulz, Stefan; Buck, Friedrich; Richter, Dietmar; Kreienkamp, Hans-Jürgen.
in: FEBS LETT, Jahrgang 581, Nr. 27, 27, 2007, S. 5173-5177.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Interaction of brain somatostatin receptors with the PDZ domains of PSD-95.
AU - Christenn, Marcus
AU - Kindler, Stefan
AU - Schulz, Stefan
AU - Buck, Friedrich
AU - Richter, Dietmar
AU - Kreienkamp, Hans-Jürgen
PY - 2007
Y1 - 2007
N2 - Using peptide affinity purification, we identified an interaction between somatostatin receptors SSTR4 and SSTR1 and PDZ domains 1 and 2 of the postsynaptic proteins postsynaptic density protein of 95kDa (PSD-95) and PSD-93. The existence of the SSTR4/PSD-95 complex was verified by coimmunoprecipitation from transfected cells and solubilized brain membranes. In neurons, dendritically localized SSTR4 partially colocalizes with postsynaptic PSD-95. As functional parameters of the receptor, such as coupling to potassium channels, are not affected by the interaction with PSD-95, the association may serve to localize the receptor to postsynaptic sites.
AB - Using peptide affinity purification, we identified an interaction between somatostatin receptors SSTR4 and SSTR1 and PDZ domains 1 and 2 of the postsynaptic proteins postsynaptic density protein of 95kDa (PSD-95) and PSD-93. The existence of the SSTR4/PSD-95 complex was verified by coimmunoprecipitation from transfected cells and solubilized brain membranes. In neurons, dendritically localized SSTR4 partially colocalizes with postsynaptic PSD-95. As functional parameters of the receptor, such as coupling to potassium channels, are not affected by the interaction with PSD-95, the association may serve to localize the receptor to postsynaptic sites.
M3 - SCORING: Zeitschriftenaufsatz
VL - 581
SP - 5173
EP - 5177
JO - FEBS LETT
JF - FEBS LETT
SN - 0014-5793
IS - 27
M1 - 27
ER -