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Integrin β1 controls VE-cadherin localization and blood vessel stability

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Integrin β1 controls VE-cadherin localization and blood vessel stability. / Yamamoto, Hiroyuki; Ehling, Manuel; Kato, Katsuhiro; Kanai, Kenichi; van Lessen, Max; Frye, Maike; Zeuschner, Dagmar; Nakayama, Masanori; Vestweber, Dietmar; Adams, Ralf H.

In: NAT COMMUN, Vol. 6, 10.03.2015, p. 6429.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Yamamoto, H, Ehling, M, Kato, K, Kanai, K, van Lessen, M, Frye, M, Zeuschner, D, Nakayama, M, Vestweber, D & Adams, RH 2015, 'Integrin β1 controls VE-cadherin localization and blood vessel stability', NAT COMMUN, vol. 6, pp. 6429. https://doi.org/10.1038/ncomms7429

APA

Yamamoto, H., Ehling, M., Kato, K., Kanai, K., van Lessen, M., Frye, M., Zeuschner, D., Nakayama, M., Vestweber, D., & Adams, R. H. (2015). Integrin β1 controls VE-cadherin localization and blood vessel stability. NAT COMMUN, 6, 6429. https://doi.org/10.1038/ncomms7429

Vancouver

Yamamoto H, Ehling M, Kato K, Kanai K, van Lessen M, Frye M et al. Integrin β1 controls VE-cadherin localization and blood vessel stability. NAT COMMUN. 2015 Mar 10;6:6429. https://doi.org/10.1038/ncomms7429

Bibtex

@article{f3640706aa6a4763bac4cdfe743761c2,
title = "Integrin β1 controls VE-cadherin localization and blood vessel stability",
abstract = "Angiogenic blood vessel growth requires several distinct but integrated cellular activities. Endothelial cell sprouting and proliferation lead to the expansion of the vasculature and give rise to a highly branched, immature plexus, which is subsequently reorganized into a mature and stable network. Although it is known that integrin-mediated cell-matrix interactions are indispensable for embryonic angiogenesis, little is known about the function of integrins in different steps of vascular morphogenesis. Here, by investigating the integrin β1-subunit with inducible and endothelial-specific gene targeting in the postnatal mouse retina, we show that β1 integrin promotes endothelial sprouting but is a negative regulator of proliferation. In maturing vessels, integrin β1 is indispensable for proper localization of VE-cadherin and thereby cell-cell junction integrity. The sum of our findings establishes that integrin β1 has critical functions in the growing and maturing vasculature, and is required for the formation of stable, non-leaky blood vessels.",
keywords = "Animals, Antigens, CD, Blotting, Western, Brain, Cadherins, Cell Proliferation, Endothelium, Gene Targeting, Image Processing, Computer-Assisted, Immunohistochemistry, Immunoprecipitation, Integrin beta1, Intercellular Junctions, Mice, Microscopy, Electron, Morphogenesis, Neovascularization, Physiologic, RNA, Small Interfering, Real-Time Polymerase Chain Reaction, Retinal Vessels, Journal Article, Research Support, Non-U.S. Gov't",
author = "Hiroyuki Yamamoto and Manuel Ehling and Katsuhiro Kato and Kenichi Kanai and {van Lessen}, Max and Maike Frye and Dagmar Zeuschner and Masanori Nakayama and Dietmar Vestweber and Adams, {Ralf H}",
year = "2015",
month = mar,
day = "10",
doi = "10.1038/ncomms7429",
language = "English",
volume = "6",
pages = "6429",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Integrin β1 controls VE-cadherin localization and blood vessel stability

AU - Yamamoto, Hiroyuki

AU - Ehling, Manuel

AU - Kato, Katsuhiro

AU - Kanai, Kenichi

AU - van Lessen, Max

AU - Frye, Maike

AU - Zeuschner, Dagmar

AU - Nakayama, Masanori

AU - Vestweber, Dietmar

AU - Adams, Ralf H

PY - 2015/3/10

Y1 - 2015/3/10

N2 - Angiogenic blood vessel growth requires several distinct but integrated cellular activities. Endothelial cell sprouting and proliferation lead to the expansion of the vasculature and give rise to a highly branched, immature plexus, which is subsequently reorganized into a mature and stable network. Although it is known that integrin-mediated cell-matrix interactions are indispensable for embryonic angiogenesis, little is known about the function of integrins in different steps of vascular morphogenesis. Here, by investigating the integrin β1-subunit with inducible and endothelial-specific gene targeting in the postnatal mouse retina, we show that β1 integrin promotes endothelial sprouting but is a negative regulator of proliferation. In maturing vessels, integrin β1 is indispensable for proper localization of VE-cadherin and thereby cell-cell junction integrity. The sum of our findings establishes that integrin β1 has critical functions in the growing and maturing vasculature, and is required for the formation of stable, non-leaky blood vessels.

AB - Angiogenic blood vessel growth requires several distinct but integrated cellular activities. Endothelial cell sprouting and proliferation lead to the expansion of the vasculature and give rise to a highly branched, immature plexus, which is subsequently reorganized into a mature and stable network. Although it is known that integrin-mediated cell-matrix interactions are indispensable for embryonic angiogenesis, little is known about the function of integrins in different steps of vascular morphogenesis. Here, by investigating the integrin β1-subunit with inducible and endothelial-specific gene targeting in the postnatal mouse retina, we show that β1 integrin promotes endothelial sprouting but is a negative regulator of proliferation. In maturing vessels, integrin β1 is indispensable for proper localization of VE-cadherin and thereby cell-cell junction integrity. The sum of our findings establishes that integrin β1 has critical functions in the growing and maturing vasculature, and is required for the formation of stable, non-leaky blood vessels.

KW - Animals

KW - Antigens, CD

KW - Blotting, Western

KW - Brain

KW - Cadherins

KW - Cell Proliferation

KW - Endothelium

KW - Gene Targeting

KW - Image Processing, Computer-Assisted

KW - Immunohistochemistry

KW - Immunoprecipitation

KW - Integrin beta1

KW - Intercellular Junctions

KW - Mice

KW - Microscopy, Electron

KW - Morphogenesis

KW - Neovascularization, Physiologic

KW - RNA, Small Interfering

KW - Real-Time Polymerase Chain Reaction

KW - Retinal Vessels

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/ncomms7429

DO - 10.1038/ncomms7429

M3 - SCORING: Journal article

C2 - 25752958

VL - 6

SP - 6429

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -