Insulin-like peptides are not involved in maturation or functional recovery of neural circuits in the locust flight system
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Insulin-like peptides are not involved in maturation or functional recovery of neural circuits in the locust flight system. / Gee, C E; Robertson, R M.
In: CAN J PHYSIOL PHARM, Vol. 79, No. 4, 01.04.2001, p. 362-6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Insulin-like peptides are not involved in maturation or functional recovery of neural circuits in the locust flight system
AU - Gee, C E
AU - Robertson, R M
PY - 2001/4/1
Y1 - 2001/4/1
N2 - We sought to manipulate maturation and functional recovery of locust flight circuitry by treating locusts with pharmacological doses of bovine anti-insulin and insulin. Anti-insulin treatment of maturing locusts caused reduced growth of the thoracic nervous system, lower body weight, and softer cuticles compared with control locusts. We were unable to block either maturation or recovery of flight circuitry with anti-insulin. We propose that insulin-related peptides are involved in growth and cuticular changes during adult maturation, but have no role in promoting neuronal sprouting during this period or as a result of injury.
AB - We sought to manipulate maturation and functional recovery of locust flight circuitry by treating locusts with pharmacological doses of bovine anti-insulin and insulin. Anti-insulin treatment of maturing locusts caused reduced growth of the thoracic nervous system, lower body weight, and softer cuticles compared with control locusts. We were unable to block either maturation or recovery of flight circuitry with anti-insulin. We propose that insulin-related peptides are involved in growth and cuticular changes during adult maturation, but have no role in promoting neuronal sprouting during this period or as a result of injury.
KW - Animals
KW - Antibodies, Anti-Idiotypic
KW - Flight, Animal
KW - Grasshoppers
KW - Hypoglycemic Agents
KW - Insulin
KW - Insulin Antibodies
KW - Male
KW - Neuronal Plasticity
KW - Wing
M3 - SCORING: Journal article
C2 - 11332514
VL - 79
SP - 362
EP - 366
JO - CAN J PHYSIOL PHARM
JF - CAN J PHYSIOL PHARM
SN - 0008-4212
IS - 4
ER -