Insulin-like peptides are not involved in maturation or functional recovery of neural circuits in the locust flight system

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Insulin-like peptides are not involved in maturation or functional recovery of neural circuits in the locust flight system. / Gee, C E; Robertson, R M.

in: CAN J PHYSIOL PHARM, Jahrgang 79, Nr. 4, 01.04.2001, S. 362-6.

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@article{d126beab751c405a9c02b87081cef5d7,
title = "Insulin-like peptides are not involved in maturation or functional recovery of neural circuits in the locust flight system",
abstract = "We sought to manipulate maturation and functional recovery of locust flight circuitry by treating locusts with pharmacological doses of bovine anti-insulin and insulin. Anti-insulin treatment of maturing locusts caused reduced growth of the thoracic nervous system, lower body weight, and softer cuticles compared with control locusts. We were unable to block either maturation or recovery of flight circuitry with anti-insulin. We propose that insulin-related peptides are involved in growth and cuticular changes during adult maturation, but have no role in promoting neuronal sprouting during this period or as a result of injury.",
keywords = "Animals, Antibodies, Anti-Idiotypic, Flight, Animal, Grasshoppers, Hypoglycemic Agents, Insulin, Insulin Antibodies, Male, Neuronal Plasticity, Wing",
author = "Gee, {C E} and Robertson, {R M}",
year = "2001",
month = apr,
day = "1",
language = "English",
volume = "79",
pages = "362--6",
journal = "CAN J PHYSIOL PHARM",
issn = "0008-4212",
publisher = "National Research Council of Canada",
number = "4",

}

RIS

TY - JOUR

T1 - Insulin-like peptides are not involved in maturation or functional recovery of neural circuits in the locust flight system

AU - Gee, C E

AU - Robertson, R M

PY - 2001/4/1

Y1 - 2001/4/1

N2 - We sought to manipulate maturation and functional recovery of locust flight circuitry by treating locusts with pharmacological doses of bovine anti-insulin and insulin. Anti-insulin treatment of maturing locusts caused reduced growth of the thoracic nervous system, lower body weight, and softer cuticles compared with control locusts. We were unable to block either maturation or recovery of flight circuitry with anti-insulin. We propose that insulin-related peptides are involved in growth and cuticular changes during adult maturation, but have no role in promoting neuronal sprouting during this period or as a result of injury.

AB - We sought to manipulate maturation and functional recovery of locust flight circuitry by treating locusts with pharmacological doses of bovine anti-insulin and insulin. Anti-insulin treatment of maturing locusts caused reduced growth of the thoracic nervous system, lower body weight, and softer cuticles compared with control locusts. We were unable to block either maturation or recovery of flight circuitry with anti-insulin. We propose that insulin-related peptides are involved in growth and cuticular changes during adult maturation, but have no role in promoting neuronal sprouting during this period or as a result of injury.

KW - Animals

KW - Antibodies, Anti-Idiotypic

KW - Flight, Animal

KW - Grasshoppers

KW - Hypoglycemic Agents

KW - Insulin

KW - Insulin Antibodies

KW - Male

KW - Neuronal Plasticity

KW - Wing

M3 - SCORING: Journal article

C2 - 11332514

VL - 79

SP - 362

EP - 366

JO - CAN J PHYSIOL PHARM

JF - CAN J PHYSIOL PHARM

SN - 0008-4212

IS - 4

ER -