Research ExplorerPublicationsInhibition of bradykinin receptor B1 protects mice from foca...

Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.

Standard

Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation. / Raslan, Furat; Schwarz, Tobias; Meuth, Sven G; Austinat, Madeleine; Bader, Michael; Renné, Thomas; Roosen, Klaus; Stoll, Guido; Sirén, Anna-Leena; Kleinschnitz, Christoph.

In: J CEREBR BLOOD F MET, Vol. 30, No. 8, 8, 2010, p. 1477-1486.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Raslan, F, Schwarz, T, Meuth, SG, Austinat, M, Bader, M, Renné, T, Roosen, K, Stoll, G, Sirén, A-L & Kleinschnitz, C 2010, 'Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.', J CEREBR BLOOD F MET, vol. 30, no. 8, 8, pp. 1477-1486. <http://www.ncbi.nlm.nih.gov/pubmed/20197781?dopt=Citation>

APA

Raslan, F., Schwarz, T., Meuth, S. G., Austinat, M., Bader, M., Renné, T., Roosen, K., Stoll, G., Sirén, A-L., & Kleinschnitz, C. (2010). Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation. J CEREBR BLOOD F MET, 30(8), 1477-1486. [8]. http://www.ncbi.nlm.nih.gov/pubmed/20197781?dopt=Citation

Vancouver

Raslan F, Schwarz T, Meuth SG, Austinat M, Bader M, Renné T et al. Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation. J CEREBR BLOOD F MET. 2010;30(8):1477-1486. 8.

Bibtex

@article{dbc268169e804f24a3920dad6481f755,
title = "Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.",
abstract = "Kinins are proinflammatory and vasoactive peptides that are released during tissue damage and may contribute to neuronal degeneration, inflammation, and edema formation after brain injury by acting on discrete bradykinin receptors, B1R and B2R. We studied the expression of B1R and B2R and the effect of their inhibition on lesion size, blood-brain barrier (BBB) disruption, and inflammatory processes after a focal cryolesion of the right parietal cortex in mice. B1R and B2R gene transcripts were significantly induced in the lesioned hemispheres of wild-type mice (P",
keywords = "Animals, Mice, Mice, Inbred C57BL, Gene Deletion, Gene Expression, Inflammation/*pathology, Brain Injuries/*prevention & control, Blood-Brain Barrier/*pathology, Cerebral Cortex/metabolism/pathology, Receptor, Bradykinin B1/*antagonists & inhibitors/genetics/*metabolism, Receptor, Bradykinin B2/antagonists & inhibitors/genetics/metabolism, Animals, Mice, Mice, Inbred C57BL, Gene Deletion, Gene Expression, Inflammation/*pathology, Brain Injuries/*prevention & control, Blood-Brain Barrier/*pathology, Cerebral Cortex/metabolism/pathology, Receptor, Bradykinin B1/*antagonists & inhibitors/genetics/*metabolism, Receptor, Bradykinin B2/antagonists & inhibitors/genetics/metabolism",
author = "Furat Raslan and Tobias Schwarz and Meuth, {Sven G} and Madeleine Austinat and Michael Bader and Thomas Renn{\'e} and Klaus Roosen and Guido Stoll and Anna-Leena Sir{\'e}n and Christoph Kleinschnitz",
year = "2010",
language = "English",
volume = "30",
pages = "1477--1486",
journal = "J CEREBR BLOOD F MET",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "8",

}

RIS

TY - JOUR

T1 - Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.

AU - Raslan, Furat

AU - Schwarz, Tobias

AU - Meuth, Sven G

AU - Austinat, Madeleine

AU - Bader, Michael

AU - Renné, Thomas

AU - Roosen, Klaus

AU - Stoll, Guido

AU - Sirén, Anna-Leena

AU - Kleinschnitz, Christoph

PY - 2010

Y1 - 2010

N2 - Kinins are proinflammatory and vasoactive peptides that are released during tissue damage and may contribute to neuronal degeneration, inflammation, and edema formation after brain injury by acting on discrete bradykinin receptors, B1R and B2R. We studied the expression of B1R and B2R and the effect of their inhibition on lesion size, blood-brain barrier (BBB) disruption, and inflammatory processes after a focal cryolesion of the right parietal cortex in mice. B1R and B2R gene transcripts were significantly induced in the lesioned hemispheres of wild-type mice (P

AB - Kinins are proinflammatory and vasoactive peptides that are released during tissue damage and may contribute to neuronal degeneration, inflammation, and edema formation after brain injury by acting on discrete bradykinin receptors, B1R and B2R. We studied the expression of B1R and B2R and the effect of their inhibition on lesion size, blood-brain barrier (BBB) disruption, and inflammatory processes after a focal cryolesion of the right parietal cortex in mice. B1R and B2R gene transcripts were significantly induced in the lesioned hemispheres of wild-type mice (P

KW - Animals

KW - Mice

KW - Mice, Inbred C57BL

KW - Gene Deletion

KW - Gene Expression

KW - Inflammation/pathology

KW - Brain Injuries/prevention & control

KW - Blood-Brain Barrier/pathology

KW - Cerebral Cortex/metabolism/pathology

KW - Receptor, Bradykinin B1/antagonists & inhibitors/genetics/metabolism

KW - Receptor, Bradykinin B2/antagonists & inhibitors/genetics/metabolism

KW - Animals

KW - Mice

KW - Mice, Inbred C57BL

KW - Gene Deletion

KW - Gene Expression

KW - Inflammation/pathology

KW - Brain Injuries/prevention & control

KW - Blood-Brain Barrier/pathology

KW - Cerebral Cortex/metabolism/pathology

KW - Receptor, Bradykinin B1/antagonists & inhibitors/genetics/metabolism

KW - Receptor, Bradykinin B2/antagonists & inhibitors/genetics/metabolism

M3 - SCORING: Journal article

VL - 30

SP - 1477

EP - 1486

JO - J CEREBR BLOOD F MET

JF - J CEREBR BLOOD F MET

SN - 0271-678X

IS - 8

M1 - 8

ER -