Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.
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Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation. / Raslan, Furat; Schwarz, Tobias; Meuth, Sven G; Austinat, Madeleine; Bader, Michael; Renné, Thomas; Roosen, Klaus; Stoll, Guido; Sirén, Anna-Leena; Kleinschnitz, Christoph.
in: J CEREBR BLOOD F MET, Jahrgang 30, Nr. 8, 8, 2010, S. 1477-1486.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.
AU - Raslan, Furat
AU - Schwarz, Tobias
AU - Meuth, Sven G
AU - Austinat, Madeleine
AU - Bader, Michael
AU - Renné, Thomas
AU - Roosen, Klaus
AU - Stoll, Guido
AU - Sirén, Anna-Leena
AU - Kleinschnitz, Christoph
PY - 2010
Y1 - 2010
N2 - Kinins are proinflammatory and vasoactive peptides that are released during tissue damage and may contribute to neuronal degeneration, inflammation, and edema formation after brain injury by acting on discrete bradykinin receptors, B1R and B2R. We studied the expression of B1R and B2R and the effect of their inhibition on lesion size, blood-brain barrier (BBB) disruption, and inflammatory processes after a focal cryolesion of the right parietal cortex in mice. B1R and B2R gene transcripts were significantly induced in the lesioned hemispheres of wild-type mice (P
AB - Kinins are proinflammatory and vasoactive peptides that are released during tissue damage and may contribute to neuronal degeneration, inflammation, and edema formation after brain injury by acting on discrete bradykinin receptors, B1R and B2R. We studied the expression of B1R and B2R and the effect of their inhibition on lesion size, blood-brain barrier (BBB) disruption, and inflammatory processes after a focal cryolesion of the right parietal cortex in mice. B1R and B2R gene transcripts were significantly induced in the lesioned hemispheres of wild-type mice (P
KW - Animals
KW - Mice
KW - Mice, Inbred C57BL
KW - Gene Deletion
KW - Gene Expression
KW - Inflammation/pathology
KW - Brain Injuries/prevention & control
KW - Blood-Brain Barrier/pathology
KW - Cerebral Cortex/metabolism/pathology
KW - Receptor, Bradykinin B1/antagonists & inhibitors/genetics/metabolism
KW - Receptor, Bradykinin B2/antagonists & inhibitors/genetics/metabolism
KW - Animals
KW - Mice
KW - Mice, Inbred C57BL
KW - Gene Deletion
KW - Gene Expression
KW - Inflammation/pathology
KW - Brain Injuries/prevention & control
KW - Blood-Brain Barrier/pathology
KW - Cerebral Cortex/metabolism/pathology
KW - Receptor, Bradykinin B1/antagonists & inhibitors/genetics/metabolism
KW - Receptor, Bradykinin B2/antagonists & inhibitors/genetics/metabolism
M3 - SCORING: Journal article
VL - 30
SP - 1477
EP - 1486
JO - J CEREBR BLOOD F MET
JF - J CEREBR BLOOD F MET
SN - 0271-678X
IS - 8
M1 - 8
ER -