Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers.
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Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers. / Julg, B; Pereyra, F; Buzón, M J; Piechocka-Trocha, A; Clark, M J; Baker, B M; Lian, J; Miura, T; Martinez-Picado, J; Addo, Marylyn; Walker, B D.
In: CLIN INFECT DIS, Vol. 51, No. 2, 2, 2010, p. 233-238.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers.
AU - Julg, B
AU - Pereyra, F
AU - Buzón, M J
AU - Piechocka-Trocha, A
AU - Clark, M J
AU - Baker, B M
AU - Lian, J
AU - Miura, T
AU - Martinez-Picado, J
AU - Addo, Marylyn
AU - Walker, B D
PY - 2010
Y1 - 2010
N2 - BACKGROUND. Human immunodeficiency virus (HIV) elite controllers are able to control infection with HIV-1 spontaneously to undetectable levels in the absence of antiretroviral therapy, but the mechanisms leading to this phenotype are poorly understood. Although low frequencies of HIV-infected peripheral CD4(+) T cells have been reported in this group, it remains unclear to what extent these are due to viral attenuation, active immune containment, or intracellular host factors that restrict virus replication. METHODS. We assessed proviral DNA levels, autologous viral growth from and infectability of in vitro activated, CD8(+) T cell-depleted CD4(+) T cells from HIV elite controllers (mean viral load,
AB - BACKGROUND. Human immunodeficiency virus (HIV) elite controllers are able to control infection with HIV-1 spontaneously to undetectable levels in the absence of antiretroviral therapy, but the mechanisms leading to this phenotype are poorly understood. Although low frequencies of HIV-infected peripheral CD4(+) T cells have been reported in this group, it remains unclear to what extent these are due to viral attenuation, active immune containment, or intracellular host factors that restrict virus replication. METHODS. We assessed proviral DNA levels, autologous viral growth from and infectability of in vitro activated, CD8(+) T cell-depleted CD4(+) T cells from HIV elite controllers (mean viral load,
KW - Humans
KW - Cells, Cultured
KW - CD4-Positive T-Lymphocytes/immunology/virology
KW - Virus Replication
KW - Virulence
KW - HIV Infections/immunology/virology
KW - HIV Long-Term Survivors
KW - HIV-1/immunology/pathogenicity
KW - Humans
KW - Cells, Cultured
KW - CD4-Positive T-Lymphocytes/immunology/virology
KW - Virus Replication
KW - Virulence
KW - HIV Infections/immunology/virology
KW - HIV Long-Term Survivors
KW - HIV-1/immunology/pathogenicity
M3 - SCORING: Journal article
VL - 51
SP - 233
EP - 238
JO - CLIN INFECT DIS
JF - CLIN INFECT DIS
SN - 1058-4838
IS - 2
M1 - 2
ER -