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Influence of pyruvate on economy of contraction in isolated rabbit myocardium.

Standard

Influence of pyruvate on economy of contraction in isolated rabbit myocardium. / Keweloh, Boris; Janssen, Paul M L; Siegel, Ulf; Datz, Nicolin; Zeitz, Oliver; Hermann, Hans-Peter.

In: EUR J HEART FAIL, Vol. 9, No. 8, 8, 2007, p. 754-761.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Keweloh, B, Janssen, PML, Siegel, U, Datz, N, Zeitz, O & Hermann, H-P 2007, 'Influence of pyruvate on economy of contraction in isolated rabbit myocardium.', EUR J HEART FAIL, vol. 9, no. 8, 8, pp. 754-761. <http://www.ncbi.nlm.nih.gov/pubmed/17532261?dopt=Citation>

APA

Keweloh, B., Janssen, P. M. L., Siegel, U., Datz, N., Zeitz, O., & Hermann, H-P. (2007). Influence of pyruvate on economy of contraction in isolated rabbit myocardium. EUR J HEART FAIL, 9(8), 754-761. [8]. http://www.ncbi.nlm.nih.gov/pubmed/17532261?dopt=Citation

Vancouver

Keweloh B, Janssen PML, Siegel U, Datz N, Zeitz O, Hermann H-P. Influence of pyruvate on economy of contraction in isolated rabbit myocardium. EUR J HEART FAIL. 2007;9(8):754-761. 8.

Bibtex

@article{4fb616f21cf44af187721c4585e1628d,
title = "Influence of pyruvate on economy of contraction in isolated rabbit myocardium.",
abstract = "BACKGROUND: Treatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which combines a favourable haemodynamic profile with low expenditure for energy metabolism. Pyruvate exhibits positive inotropic effects in vitro and in patients with heart failure. The effect on myocardial energy metabolism however remains unclear, but is meaningful in light of a clinical application. AIMS AND METHODS: We investigated the influence of pyruvate on contractility and oxygen consumption in isolated isometric contracting rabbit myocardium compared to beta-adrenergic stimulation with isoproterenol. RESULTS: Pyruvate (30 mM) increased developed force from 18.7+/-4.1 to 50.8+/-12.1 mN/mm2 (n=10, p",
author = "Boris Keweloh and Janssen, {Paul M L} and Ulf Siegel and Nicolin Datz and Oliver Zeitz and Hans-Peter Hermann",
year = "2007",
language = "Deutsch",
volume = "9",
pages = "754--761",
journal = "EUR J HEART FAIL",
issn = "1388-9842",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Influence of pyruvate on economy of contraction in isolated rabbit myocardium.

AU - Keweloh, Boris

AU - Janssen, Paul M L

AU - Siegel, Ulf

AU - Datz, Nicolin

AU - Zeitz, Oliver

AU - Hermann, Hans-Peter

PY - 2007

Y1 - 2007

N2 - BACKGROUND: Treatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which combines a favourable haemodynamic profile with low expenditure for energy metabolism. Pyruvate exhibits positive inotropic effects in vitro and in patients with heart failure. The effect on myocardial energy metabolism however remains unclear, but is meaningful in light of a clinical application. AIMS AND METHODS: We investigated the influence of pyruvate on contractility and oxygen consumption in isolated isometric contracting rabbit myocardium compared to beta-adrenergic stimulation with isoproterenol. RESULTS: Pyruvate (30 mM) increased developed force from 18.7+/-4.1 to 50.8+/-12.1 mN/mm2 (n=10, p

AB - BACKGROUND: Treatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which combines a favourable haemodynamic profile with low expenditure for energy metabolism. Pyruvate exhibits positive inotropic effects in vitro and in patients with heart failure. The effect on myocardial energy metabolism however remains unclear, but is meaningful in light of a clinical application. AIMS AND METHODS: We investigated the influence of pyruvate on contractility and oxygen consumption in isolated isometric contracting rabbit myocardium compared to beta-adrenergic stimulation with isoproterenol. RESULTS: Pyruvate (30 mM) increased developed force from 18.7+/-4.1 to 50.8+/-12.1 mN/mm2 (n=10, p

M3 - SCORING: Zeitschriftenaufsatz

VL - 9

SP - 754

EP - 761

JO - EUR J HEART FAIL

JF - EUR J HEART FAIL

SN - 1388-9842

IS - 8

M1 - 8

ER -