Influence of pyruvate on economy of contraction in isolated rabbit myocardium.
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Influence of pyruvate on economy of contraction in isolated rabbit myocardium. / Keweloh, Boris; Janssen, Paul M L; Siegel, Ulf; Datz, Nicolin; Zeitz, Oliver; Hermann, Hans-Peter.
in: EUR J HEART FAIL, Jahrgang 9, Nr. 8, 8, 2007, S. 754-761.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Influence of pyruvate on economy of contraction in isolated rabbit myocardium.
AU - Keweloh, Boris
AU - Janssen, Paul M L
AU - Siegel, Ulf
AU - Datz, Nicolin
AU - Zeitz, Oliver
AU - Hermann, Hans-Peter
PY - 2007
Y1 - 2007
N2 - BACKGROUND: Treatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which combines a favourable haemodynamic profile with low expenditure for energy metabolism. Pyruvate exhibits positive inotropic effects in vitro and in patients with heart failure. The effect on myocardial energy metabolism however remains unclear, but is meaningful in light of a clinical application. AIMS AND METHODS: We investigated the influence of pyruvate on contractility and oxygen consumption in isolated isometric contracting rabbit myocardium compared to beta-adrenergic stimulation with isoproterenol. RESULTS: Pyruvate (30 mM) increased developed force from 18.7+/-4.1 to 50.8+/-12.1 mN/mm2 (n=10, p
AB - BACKGROUND: Treatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which combines a favourable haemodynamic profile with low expenditure for energy metabolism. Pyruvate exhibits positive inotropic effects in vitro and in patients with heart failure. The effect on myocardial energy metabolism however remains unclear, but is meaningful in light of a clinical application. AIMS AND METHODS: We investigated the influence of pyruvate on contractility and oxygen consumption in isolated isometric contracting rabbit myocardium compared to beta-adrenergic stimulation with isoproterenol. RESULTS: Pyruvate (30 mM) increased developed force from 18.7+/-4.1 to 50.8+/-12.1 mN/mm2 (n=10, p
M3 - SCORING: Zeitschriftenaufsatz
VL - 9
SP - 754
EP - 761
JO - EUR J HEART FAIL
JF - EUR J HEART FAIL
SN - 1388-9842
IS - 8
M1 - 8
ER -