Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium.
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Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium. / Hasenfuss, Gerd; Maier, Lars S; Hermann, Hans-Peter; Lüers, Claus; Hünlich, Mark; Zeitz, Oliver; Janssen, Paul M L; Pieske, Burkert.
In: CIRCULATION, Vol. 105, No. 2, 2, 2002, p. 194-199.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium.
AU - Hasenfuss, Gerd
AU - Maier, Lars S
AU - Hermann, Hans-Peter
AU - Lüers, Claus
AU - Hünlich, Mark
AU - Zeitz, Oliver
AU - Janssen, Paul M L
AU - Pieske, Burkert
PY - 2002
Y1 - 2002
N2 - BACKGROUND: Application of pyruvate was shown to improve contractile function in isolated animal myocardium and hemodynamics in patients with congestive heart failure. We assessed the influence of pyruvate on systolic and diastolic myocardial function and its subcellular mode of action in isolated myocardium from end-stage failing human hearts. METHODS AND RESULTS: In muscle strip preparations, concentration-dependent effects of pyruvate on developed and diastolic force (n=6), aequorin light emission reflecting intracellular Ca(2+) transients (n=6), and rapid cooling contractures reflecting sarcoplasmic reticulum (SR) Ca(2+) content (n=11) were measured. Pyruvate resulted in a concentration-dependent increase in developed force and a decrease in diastolic force, with a maximum effect of 155% and 21%, respectively, at 20 mmol/L pyruvate (P
AB - BACKGROUND: Application of pyruvate was shown to improve contractile function in isolated animal myocardium and hemodynamics in patients with congestive heart failure. We assessed the influence of pyruvate on systolic and diastolic myocardial function and its subcellular mode of action in isolated myocardium from end-stage failing human hearts. METHODS AND RESULTS: In muscle strip preparations, concentration-dependent effects of pyruvate on developed and diastolic force (n=6), aequorin light emission reflecting intracellular Ca(2+) transients (n=6), and rapid cooling contractures reflecting sarcoplasmic reticulum (SR) Ca(2+) content (n=11) were measured. Pyruvate resulted in a concentration-dependent increase in developed force and a decrease in diastolic force, with a maximum effect of 155% and 21%, respectively, at 20 mmol/L pyruvate (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 105
SP - 194
EP - 199
JO - CIRCULATION
JF - CIRCULATION
SN - 0009-7322
IS - 2
M1 - 2
ER -