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Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium.

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Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium. / Hasenfuss, Gerd; Maier, Lars S; Hermann, Hans-Peter; Lüers, Claus; Hünlich, Mark; Zeitz, Oliver; Janssen, Paul M L; Pieske, Burkert.

in: CIRCULATION, Jahrgang 105, Nr. 2, 2, 2002, S. 194-199.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hasenfuss, G, Maier, LS, Hermann, H-P, Lüers, C, Hünlich, M, Zeitz, O, Janssen, PML & Pieske, B 2002, 'Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium.', CIRCULATION, Jg. 105, Nr. 2, 2, S. 194-199. <http://www.ncbi.nlm.nih.gov/pubmed/11790700?dopt=Citation>

APA

Hasenfuss, G., Maier, L. S., Hermann, H-P., Lüers, C., Hünlich, M., Zeitz, O., Janssen, P. M. L., & Pieske, B. (2002). Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium. CIRCULATION, 105(2), 194-199. [2]. http://www.ncbi.nlm.nih.gov/pubmed/11790700?dopt=Citation

Vancouver

Hasenfuss G, Maier LS, Hermann H-P, Lüers C, Hünlich M, Zeitz O et al. Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium. CIRCULATION. 2002;105(2):194-199. 2.

Bibtex

@article{9e9d155ab4d6404dbc8eb270035eae71,
title = "Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium.",
abstract = "BACKGROUND: Application of pyruvate was shown to improve contractile function in isolated animal myocardium and hemodynamics in patients with congestive heart failure. We assessed the influence of pyruvate on systolic and diastolic myocardial function and its subcellular mode of action in isolated myocardium from end-stage failing human hearts. METHODS AND RESULTS: In muscle strip preparations, concentration-dependent effects of pyruvate on developed and diastolic force (n=6), aequorin light emission reflecting intracellular Ca(2+) transients (n=6), and rapid cooling contractures reflecting sarcoplasmic reticulum (SR) Ca(2+) content (n=11) were measured. Pyruvate resulted in a concentration-dependent increase in developed force and a decrease in diastolic force, with a maximum effect of 155% and 21%, respectively, at 20 mmol/L pyruvate (P",
author = "Gerd Hasenfuss and Maier, {Lars S} and Hans-Peter Hermann and Claus L{\"u}ers and Mark H{\"u}nlich and Oliver Zeitz and Janssen, {Paul M L} and Burkert Pieske",
year = "2002",
language = "Deutsch",
volume = "105",
pages = "194--199",
journal = "CIRCULATION",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium.

AU - Hasenfuss, Gerd

AU - Maier, Lars S

AU - Hermann, Hans-Peter

AU - Lüers, Claus

AU - Hünlich, Mark

AU - Zeitz, Oliver

AU - Janssen, Paul M L

AU - Pieske, Burkert

PY - 2002

Y1 - 2002

N2 - BACKGROUND: Application of pyruvate was shown to improve contractile function in isolated animal myocardium and hemodynamics in patients with congestive heart failure. We assessed the influence of pyruvate on systolic and diastolic myocardial function and its subcellular mode of action in isolated myocardium from end-stage failing human hearts. METHODS AND RESULTS: In muscle strip preparations, concentration-dependent effects of pyruvate on developed and diastolic force (n=6), aequorin light emission reflecting intracellular Ca(2+) transients (n=6), and rapid cooling contractures reflecting sarcoplasmic reticulum (SR) Ca(2+) content (n=11) were measured. Pyruvate resulted in a concentration-dependent increase in developed force and a decrease in diastolic force, with a maximum effect of 155% and 21%, respectively, at 20 mmol/L pyruvate (P

AB - BACKGROUND: Application of pyruvate was shown to improve contractile function in isolated animal myocardium and hemodynamics in patients with congestive heart failure. We assessed the influence of pyruvate on systolic and diastolic myocardial function and its subcellular mode of action in isolated myocardium from end-stage failing human hearts. METHODS AND RESULTS: In muscle strip preparations, concentration-dependent effects of pyruvate on developed and diastolic force (n=6), aequorin light emission reflecting intracellular Ca(2+) transients (n=6), and rapid cooling contractures reflecting sarcoplasmic reticulum (SR) Ca(2+) content (n=11) were measured. Pyruvate resulted in a concentration-dependent increase in developed force and a decrease in diastolic force, with a maximum effect of 155% and 21%, respectively, at 20 mmol/L pyruvate (P

M3 - SCORING: Zeitschriftenaufsatz

VL - 105

SP - 194

EP - 199

JO - CIRCULATION

JF - CIRCULATION

SN - 0009-7322

IS - 2

M1 - 2

ER -