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Influence of female sex and fertile age on neuromyelitis optica spectrum disorders

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Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. / Borisow, Nadja; Kleiter, Ingo; Gahlen, Anna; Fischer, Katrin; Wernecke, Klaus-Dieter; Pache, Florence; Ruprecht, Klemens; Havla, Joachim; Krumbholz, Markus; Kümpfel, Tania; Aktas, Orhan; Ringelstein, Marius; Geis, Christian; Kleinschnitz, Christoph; Berthele, Achim; Hemmer, Bernhard; Angstwurm, Klemens; Weissert, Robert; Stellmann, Jan-Patrick; Schuster, Simon; Stangel, Martin; Lauda, Florian; Tumani, Hayrettin; Mayer, Christoph; Zeltner, Lena; Ziemann, Ulf; Linker, Ralf A; Schwab, Matthias; Marziniak, Martin; Then Bergh, Florian; Hofstadt-van Oy, Ulrich; Neuhaus, Oliver; Winkelmann, Alexander; Marouf, Wael; Rückriem, Lioba; Faiss, Jürgen; Wildemann, Brigitte; Paul, Friedemann; Jarius, Sven; Trebst, Corinna; Hellwig, Kerstin; NEMOS (Neuromyelitis Optica Study Group).

In: MULT SCLER J, Vol. 23, No. 8, 07.2017, p. 1092-1103.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Borisow, N, Kleiter, I, Gahlen, A, Fischer, K, Wernecke, K-D, Pache, F, Ruprecht, K, Havla, J, Krumbholz, M, Kümpfel, T, Aktas, O, Ringelstein, M, Geis, C, Kleinschnitz, C, Berthele, A, Hemmer, B, Angstwurm, K, Weissert, R, Stellmann, J-P, Schuster, S, Stangel, M, Lauda, F, Tumani, H, Mayer, C, Zeltner, L, Ziemann, U, Linker, RA, Schwab, M, Marziniak, M, Then Bergh, F, Hofstadt-van Oy, U, Neuhaus, O, Winkelmann, A, Marouf, W, Rückriem, L, Faiss, J, Wildemann, B, Paul, F, Jarius, S, Trebst, C, Hellwig, K & NEMOS (Neuromyelitis Optica Study Group) 2017, 'Influence of female sex and fertile age on neuromyelitis optica spectrum disorders', MULT SCLER J, vol. 23, no. 8, pp. 1092-1103. https://doi.org/10.1177/1352458516671203

APA

Borisow, N., Kleiter, I., Gahlen, A., Fischer, K., Wernecke, K-D., Pache, F., Ruprecht, K., Havla, J., Krumbholz, M., Kümpfel, T., Aktas, O., Ringelstein, M., Geis, C., Kleinschnitz, C., Berthele, A., Hemmer, B., Angstwurm, K., Weissert, R., Stellmann, J-P., ... NEMOS (Neuromyelitis Optica Study Group) (2017). Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. MULT SCLER J, 23(8), 1092-1103. https://doi.org/10.1177/1352458516671203

Vancouver

Borisow N, Kleiter I, Gahlen A, Fischer K, Wernecke K-D, Pache F et al. Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. MULT SCLER J. 2017 Jul;23(8):1092-1103. https://doi.org/10.1177/1352458516671203

Bibtex

@article{5db5841bddee46228397b8d6cc2ab09e,
title = "Influence of female sex and fertile age on neuromyelitis optica spectrum disorders",
abstract = "BACKGROUND: Gender and age at onset are important epidemiological factors influencing prevalence, clinical presentation, and treatment response in autoimmune diseases.OBJECTIVE: To evaluate the impact of female sex and fertile age on aquaporin-4-antibody (AQP4-ab) status, attack localization, and response to attack treatment in patients with neuromyelitis optica (NMO) and its spectrum disorders (neuromyelitis optica spectrum disorder (NMOSD)).METHODS: Female-to-male ratios, diagnosis at last visit (NMO vs NMOSD), attack localization, attack treatment, and outcome were compared according to sex and age at disease or attack onset.RESULTS: A total of 186 NMO/SD patients (82% female) were included. In AQP4-ab-positive patients, female predominance was most pronounced during fertile age (female-to-male ratio 23:1). Female patients were more likely to be positive for AQP4-abs (92% vs 55%; p < 0.001). Interval between onset and diagnosis of NMO/SD was longer in women than in men (mean 54 vs 27 months; p = 0.023). In women, attacks occurring ⩽40 years of age were more likely to show complete remission (p = 0.003) and better response to high-dose intravenous steroids (p = 0.005) compared to woman at >40 years.CONCLUSION: Our data suggest an influence of sex and age on susceptibility to AQP4-ab-positive NMO/SD. Genetic and hormonal factors might contribute to pathophysiology of NMO/SD.",
author = "Nadja Borisow and Ingo Kleiter and Anna Gahlen and Katrin Fischer and Klaus-Dieter Wernecke and Florence Pache and Klemens Ruprecht and Joachim Havla and Markus Krumbholz and Tania K{\"u}mpfel and Orhan Aktas and Marius Ringelstein and Christian Geis and Christoph Kleinschnitz and Achim Berthele and Bernhard Hemmer and Klemens Angstwurm and Robert Weissert and Jan-Patrick Stellmann and Simon Schuster and Martin Stangel and Florian Lauda and Hayrettin Tumani and Christoph Mayer and Lena Zeltner and Ulf Ziemann and Linker, {Ralf A} and Matthias Schwab and Martin Marziniak and {Then Bergh}, Florian and {Hofstadt-van Oy}, Ulrich and Oliver Neuhaus and Alexander Winkelmann and Wael Marouf and Lioba R{\"u}ckriem and J{\"u}rgen Faiss and Brigitte Wildemann and Friedemann Paul and Sven Jarius and Corinna Trebst and Kerstin Hellwig and {NEMOS (Neuromyelitis Optica Study Group)}",
note = "{\textcopyright} The Author(s), 2016.",
year = "2017",
month = jul,
doi = "10.1177/1352458516671203",
language = "English",
volume = "23",
pages = "1092--1103",
journal = "MULT SCLER J",
issn = "1352-4585",
publisher = "SAGE Publications",
number = "8",

}

RIS

TY - JOUR

T1 - Influence of female sex and fertile age on neuromyelitis optica spectrum disorders

AU - Borisow, Nadja

AU - Kleiter, Ingo

AU - Gahlen, Anna

AU - Fischer, Katrin

AU - Wernecke, Klaus-Dieter

AU - Pache, Florence

AU - Ruprecht, Klemens

AU - Havla, Joachim

AU - Krumbholz, Markus

AU - Kümpfel, Tania

AU - Aktas, Orhan

AU - Ringelstein, Marius

AU - Geis, Christian

AU - Kleinschnitz, Christoph

AU - Berthele, Achim

AU - Hemmer, Bernhard

AU - Angstwurm, Klemens

AU - Weissert, Robert

AU - Stellmann, Jan-Patrick

AU - Schuster, Simon

AU - Stangel, Martin

AU - Lauda, Florian

AU - Tumani, Hayrettin

AU - Mayer, Christoph

AU - Zeltner, Lena

AU - Ziemann, Ulf

AU - Linker, Ralf A

AU - Schwab, Matthias

AU - Marziniak, Martin

AU - Then Bergh, Florian

AU - Hofstadt-van Oy, Ulrich

AU - Neuhaus, Oliver

AU - Winkelmann, Alexander

AU - Marouf, Wael

AU - Rückriem, Lioba

AU - Faiss, Jürgen

AU - Wildemann, Brigitte

AU - Paul, Friedemann

AU - Jarius, Sven

AU - Trebst, Corinna

AU - Hellwig, Kerstin

AU - NEMOS (Neuromyelitis Optica Study Group)

N1 - © The Author(s), 2016.

PY - 2017/7

Y1 - 2017/7

N2 - BACKGROUND: Gender and age at onset are important epidemiological factors influencing prevalence, clinical presentation, and treatment response in autoimmune diseases.OBJECTIVE: To evaluate the impact of female sex and fertile age on aquaporin-4-antibody (AQP4-ab) status, attack localization, and response to attack treatment in patients with neuromyelitis optica (NMO) and its spectrum disorders (neuromyelitis optica spectrum disorder (NMOSD)).METHODS: Female-to-male ratios, diagnosis at last visit (NMO vs NMOSD), attack localization, attack treatment, and outcome were compared according to sex and age at disease or attack onset.RESULTS: A total of 186 NMO/SD patients (82% female) were included. In AQP4-ab-positive patients, female predominance was most pronounced during fertile age (female-to-male ratio 23:1). Female patients were more likely to be positive for AQP4-abs (92% vs 55%; p < 0.001). Interval between onset and diagnosis of NMO/SD was longer in women than in men (mean 54 vs 27 months; p = 0.023). In women, attacks occurring ⩽40 years of age were more likely to show complete remission (p = 0.003) and better response to high-dose intravenous steroids (p = 0.005) compared to woman at >40 years.CONCLUSION: Our data suggest an influence of sex and age on susceptibility to AQP4-ab-positive NMO/SD. Genetic and hormonal factors might contribute to pathophysiology of NMO/SD.

AB - BACKGROUND: Gender and age at onset are important epidemiological factors influencing prevalence, clinical presentation, and treatment response in autoimmune diseases.OBJECTIVE: To evaluate the impact of female sex and fertile age on aquaporin-4-antibody (AQP4-ab) status, attack localization, and response to attack treatment in patients with neuromyelitis optica (NMO) and its spectrum disorders (neuromyelitis optica spectrum disorder (NMOSD)).METHODS: Female-to-male ratios, diagnosis at last visit (NMO vs NMOSD), attack localization, attack treatment, and outcome were compared according to sex and age at disease or attack onset.RESULTS: A total of 186 NMO/SD patients (82% female) were included. In AQP4-ab-positive patients, female predominance was most pronounced during fertile age (female-to-male ratio 23:1). Female patients were more likely to be positive for AQP4-abs (92% vs 55%; p < 0.001). Interval between onset and diagnosis of NMO/SD was longer in women than in men (mean 54 vs 27 months; p = 0.023). In women, attacks occurring ⩽40 years of age were more likely to show complete remission (p = 0.003) and better response to high-dose intravenous steroids (p = 0.005) compared to woman at >40 years.CONCLUSION: Our data suggest an influence of sex and age on susceptibility to AQP4-ab-positive NMO/SD. Genetic and hormonal factors might contribute to pathophysiology of NMO/SD.

U2 - 10.1177/1352458516671203

DO - 10.1177/1352458516671203

M3 - SCORING: Journal article

C2 - 27758954

VL - 23

SP - 1092

EP - 1103

JO - MULT SCLER J

JF - MULT SCLER J

SN - 1352-4585

IS - 8

ER -