Influence of female sex and fertile age on neuromyelitis optica spectrum disorders
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Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. / Borisow, Nadja; Kleiter, Ingo; Gahlen, Anna; Fischer, Katrin; Wernecke, Klaus-Dieter; Pache, Florence; Ruprecht, Klemens; Havla, Joachim; Krumbholz, Markus; Kümpfel, Tania; Aktas, Orhan; Ringelstein, Marius; Geis, Christian; Kleinschnitz, Christoph; Berthele, Achim; Hemmer, Bernhard; Angstwurm, Klemens; Weissert, Robert; Stellmann, Jan-Patrick; Schuster, Simon; Stangel, Martin; Lauda, Florian; Tumani, Hayrettin; Mayer, Christoph; Zeltner, Lena; Ziemann, Ulf; Linker, Ralf A; Schwab, Matthias; Marziniak, Martin; Then Bergh, Florian; Hofstadt-van Oy, Ulrich; Neuhaus, Oliver; Winkelmann, Alexander; Marouf, Wael; Rückriem, Lioba; Faiss, Jürgen; Wildemann, Brigitte; Paul, Friedemann; Jarius, Sven; Trebst, Corinna; Hellwig, Kerstin; NEMOS (Neuromyelitis Optica Study Group).
in: MULT SCLER J, Jahrgang 23, Nr. 8, 07.2017, S. 1092-1103.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Influence of female sex and fertile age on neuromyelitis optica spectrum disorders
AU - Borisow, Nadja
AU - Kleiter, Ingo
AU - Gahlen, Anna
AU - Fischer, Katrin
AU - Wernecke, Klaus-Dieter
AU - Pache, Florence
AU - Ruprecht, Klemens
AU - Havla, Joachim
AU - Krumbholz, Markus
AU - Kümpfel, Tania
AU - Aktas, Orhan
AU - Ringelstein, Marius
AU - Geis, Christian
AU - Kleinschnitz, Christoph
AU - Berthele, Achim
AU - Hemmer, Bernhard
AU - Angstwurm, Klemens
AU - Weissert, Robert
AU - Stellmann, Jan-Patrick
AU - Schuster, Simon
AU - Stangel, Martin
AU - Lauda, Florian
AU - Tumani, Hayrettin
AU - Mayer, Christoph
AU - Zeltner, Lena
AU - Ziemann, Ulf
AU - Linker, Ralf A
AU - Schwab, Matthias
AU - Marziniak, Martin
AU - Then Bergh, Florian
AU - Hofstadt-van Oy, Ulrich
AU - Neuhaus, Oliver
AU - Winkelmann, Alexander
AU - Marouf, Wael
AU - Rückriem, Lioba
AU - Faiss, Jürgen
AU - Wildemann, Brigitte
AU - Paul, Friedemann
AU - Jarius, Sven
AU - Trebst, Corinna
AU - Hellwig, Kerstin
AU - NEMOS (Neuromyelitis Optica Study Group)
N1 - © The Author(s), 2016.
PY - 2017/7
Y1 - 2017/7
N2 - BACKGROUND: Gender and age at onset are important epidemiological factors influencing prevalence, clinical presentation, and treatment response in autoimmune diseases.OBJECTIVE: To evaluate the impact of female sex and fertile age on aquaporin-4-antibody (AQP4-ab) status, attack localization, and response to attack treatment in patients with neuromyelitis optica (NMO) and its spectrum disorders (neuromyelitis optica spectrum disorder (NMOSD)).METHODS: Female-to-male ratios, diagnosis at last visit (NMO vs NMOSD), attack localization, attack treatment, and outcome were compared according to sex and age at disease or attack onset.RESULTS: A total of 186 NMO/SD patients (82% female) were included. In AQP4-ab-positive patients, female predominance was most pronounced during fertile age (female-to-male ratio 23:1). Female patients were more likely to be positive for AQP4-abs (92% vs 55%; p < 0.001). Interval between onset and diagnosis of NMO/SD was longer in women than in men (mean 54 vs 27 months; p = 0.023). In women, attacks occurring ⩽40 years of age were more likely to show complete remission (p = 0.003) and better response to high-dose intravenous steroids (p = 0.005) compared to woman at >40 years.CONCLUSION: Our data suggest an influence of sex and age on susceptibility to AQP4-ab-positive NMO/SD. Genetic and hormonal factors might contribute to pathophysiology of NMO/SD.
AB - BACKGROUND: Gender and age at onset are important epidemiological factors influencing prevalence, clinical presentation, and treatment response in autoimmune diseases.OBJECTIVE: To evaluate the impact of female sex and fertile age on aquaporin-4-antibody (AQP4-ab) status, attack localization, and response to attack treatment in patients with neuromyelitis optica (NMO) and its spectrum disorders (neuromyelitis optica spectrum disorder (NMOSD)).METHODS: Female-to-male ratios, diagnosis at last visit (NMO vs NMOSD), attack localization, attack treatment, and outcome were compared according to sex and age at disease or attack onset.RESULTS: A total of 186 NMO/SD patients (82% female) were included. In AQP4-ab-positive patients, female predominance was most pronounced during fertile age (female-to-male ratio 23:1). Female patients were more likely to be positive for AQP4-abs (92% vs 55%; p < 0.001). Interval between onset and diagnosis of NMO/SD was longer in women than in men (mean 54 vs 27 months; p = 0.023). In women, attacks occurring ⩽40 years of age were more likely to show complete remission (p = 0.003) and better response to high-dose intravenous steroids (p = 0.005) compared to woman at >40 years.CONCLUSION: Our data suggest an influence of sex and age on susceptibility to AQP4-ab-positive NMO/SD. Genetic and hormonal factors might contribute to pathophysiology of NMO/SD.
U2 - 10.1177/1352458516671203
DO - 10.1177/1352458516671203
M3 - SCORING: Journal article
C2 - 27758954
VL - 23
SP - 1092
EP - 1103
JO - MULT SCLER J
JF - MULT SCLER J
SN - 1352-4585
IS - 8
ER -