Inference of neuronal functional circuitry with spike-triggered non-negative matrix factorization
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Inference of neuronal functional circuitry with spike-triggered non-negative matrix factorization. / Liu, Jian K; Schreyer, Helene M; Onken, Arno; Rozenblit, Fernando; Khani, Mohammad H; Krishnamoorthy, Vidhyasankar; Panzeri, Stefano; Gollisch, Tim.
In: NAT COMMUN, Vol. 8, No. 1, 26.07.2017, p. 149.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Inference of neuronal functional circuitry with spike-triggered non-negative matrix factorization
AU - Liu, Jian K
AU - Schreyer, Helene M
AU - Onken, Arno
AU - Rozenblit, Fernando
AU - Khani, Mohammad H
AU - Krishnamoorthy, Vidhyasankar
AU - Panzeri, Stefano
AU - Gollisch, Tim
PY - 2017/7/26
Y1 - 2017/7/26
N2 - Neurons in sensory systems often pool inputs over arrays of presynaptic cells, giving rise to functional subunits inside a neuron's receptive field. The organization of these subunits provides a signature of the neuron's presynaptic functional connectivity and determines how the neuron integrates sensory stimuli. Here we introduce the method of spike-triggered non-negative matrix factorization for detecting the layout of subunits within a neuron's receptive field. The method only requires the neuron's spiking responses under finely structured sensory stimulation and is therefore applicable to large populations of simultaneously recorded neurons. Applied to recordings from ganglion cells in the salamander retina, the method retrieves the receptive fields of presynaptic bipolar cells, as verified by simultaneous bipolar and ganglion cell recordings. The identified subunit layouts allow improved predictions of ganglion cell responses to natural stimuli and reveal shared bipolar cell input into distinct types of ganglion cells.How a neuron integrates sensory information requires knowledge about its functional presynaptic connections. Here the authors report a new method using non-negative matrix factorization to identify the layout of presynaptic bipolar cell inputs onto retinal ganglion cells and predict their responses to natural stimuli.
AB - Neurons in sensory systems often pool inputs over arrays of presynaptic cells, giving rise to functional subunits inside a neuron's receptive field. The organization of these subunits provides a signature of the neuron's presynaptic functional connectivity and determines how the neuron integrates sensory stimuli. Here we introduce the method of spike-triggered non-negative matrix factorization for detecting the layout of subunits within a neuron's receptive field. The method only requires the neuron's spiking responses under finely structured sensory stimulation and is therefore applicable to large populations of simultaneously recorded neurons. Applied to recordings from ganglion cells in the salamander retina, the method retrieves the receptive fields of presynaptic bipolar cells, as verified by simultaneous bipolar and ganglion cell recordings. The identified subunit layouts allow improved predictions of ganglion cell responses to natural stimuli and reveal shared bipolar cell input into distinct types of ganglion cells.How a neuron integrates sensory information requires knowledge about its functional presynaptic connections. Here the authors report a new method using non-negative matrix factorization to identify the layout of presynaptic bipolar cell inputs onto retinal ganglion cells and predict their responses to natural stimuli.
KW - Action Potentials/physiology
KW - Algorithms
KW - Ambystoma mexicanum
KW - Animals
KW - Female
KW - Male
KW - Models, Neurological
KW - Photic Stimulation
KW - Presynaptic Terminals/physiology
KW - Retina/cytology
KW - Retinal Ganglion Cells/physiology
KW - Visual Fields/physiology
U2 - 10.1038/s41467-017-00156-9
DO - 10.1038/s41467-017-00156-9
M3 - SCORING: Journal article
C2 - 28747662
VL - 8
SP - 149
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
IS - 1
ER -