Inference of neuronal functional circuitry with spike-triggered non-negative matrix factorization

TY - JOUR

T1 - Inference of neuronal functional circuitry with spike-triggered non-negative matrix factorization

AU - Liu, Jian K

AU - Schreyer, Helene M

AU - Onken, Arno

AU - Rozenblit, Fernando

AU - Khani, Mohammad H

AU - Krishnamoorthy, Vidhyasankar

AU - Panzeri, Stefano

AU - Gollisch, Tim

PY - 2017/7/26

Y1 - 2017/7/26

N2 - Neurons in sensory systems often pool inputs over arrays of presynaptic cells, giving rise to functional subunits inside a neuron's receptive field. The organization of these subunits provides a signature of the neuron's presynaptic functional connectivity and determines how the neuron integrates sensory stimuli. Here we introduce the method of spike-triggered non-negative matrix factorization for detecting the layout of subunits within a neuron's receptive field. The method only requires the neuron's spiking responses under finely structured sensory stimulation and is therefore applicable to large populations of simultaneously recorded neurons. Applied to recordings from ganglion cells in the salamander retina, the method retrieves the receptive fields of presynaptic bipolar cells, as verified by simultaneous bipolar and ganglion cell recordings. The identified subunit layouts allow improved predictions of ganglion cell responses to natural stimuli and reveal shared bipolar cell input into distinct types of ganglion cells.How a neuron integrates sensory information requires knowledge about its functional presynaptic connections. Here the authors report a new method using non-negative matrix factorization to identify the layout of presynaptic bipolar cell inputs onto retinal ganglion cells and predict their responses to natural stimuli.

AB - Neurons in sensory systems often pool inputs over arrays of presynaptic cells, giving rise to functional subunits inside a neuron's receptive field. The organization of these subunits provides a signature of the neuron's presynaptic functional connectivity and determines how the neuron integrates sensory stimuli. Here we introduce the method of spike-triggered non-negative matrix factorization for detecting the layout of subunits within a neuron's receptive field. The method only requires the neuron's spiking responses under finely structured sensory stimulation and is therefore applicable to large populations of simultaneously recorded neurons. Applied to recordings from ganglion cells in the salamander retina, the method retrieves the receptive fields of presynaptic bipolar cells, as verified by simultaneous bipolar and ganglion cell recordings. The identified subunit layouts allow improved predictions of ganglion cell responses to natural stimuli and reveal shared bipolar cell input into distinct types of ganglion cells.How a neuron integrates sensory information requires knowledge about its functional presynaptic connections. Here the authors report a new method using non-negative matrix factorization to identify the layout of presynaptic bipolar cell inputs onto retinal ganglion cells and predict their responses to natural stimuli.

KW - Action Potentials/physiology

KW - Algorithms

KW - Ambystoma mexicanum

KW - Animals

KW - Female

KW - Male

KW - Models, Neurological

KW - Photic Stimulation

KW - Presynaptic Terminals/physiology

KW - Retina/cytology

KW - Retinal Ganglion Cells/physiology

KW - Visual Fields/physiology

U2 - 10.1038/s41467-017-00156-9

DO - 10.1038/s41467-017-00156-9

M3 - SCORING: Journal article

C2 - 28747662

VL - 8

SP - 149

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -