Induction chemotherapy before chemoradiotherapy and surgery for locally advanced rectal cancer : is it time for a randomized phase III trial?
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Induction chemotherapy before chemoradiotherapy and surgery for locally advanced rectal cancer : is it time for a randomized phase III trial? / Rödel, Claus; Arnold, Dirk; Becker, Heinz; Fietkau, Rainer; Ghadimi, Michael; Graeven, Ullrich; Hess, Clemens; Hofheinz, Ralf; Hohenberger, Werner; Post, Stefan; Raab, Rudolf; Sauer, Rolf; Wenz, Frederick; Liersch, Torsten.
In: STRAHLENTHER ONKOL, Vol. 186, No. 12, 12, 2010, p. 658-664.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Induction chemotherapy before chemoradiotherapy and surgery for locally advanced rectal cancer : is it time for a randomized phase III trial?
AU - Rödel, Claus
AU - Arnold, Dirk
AU - Becker, Heinz
AU - Fietkau, Rainer
AU - Ghadimi, Michael
AU - Graeven, Ullrich
AU - Hess, Clemens
AU - Hofheinz, Ralf
AU - Hohenberger, Werner
AU - Post, Stefan
AU - Raab, Rudolf
AU - Sauer, Rolf
AU - Wenz, Frederick
AU - Liersch, Torsten
PY - 2010
Y1 - 2010
N2 - in the era of preoperative chemoradiotherapy (CRT) and total mesorectal excision (TME), the development of distant metastases is the predominant mode of failure in rectal cancer patients today. Integrating more effective systemic therapy into combined modality programs is the challenge. The question that needs to be addressed is how and when to apply systemic treatment with adequate dose and intensity.
AB - in the era of preoperative chemoradiotherapy (CRT) and total mesorectal excision (TME), the development of distant metastases is the predominant mode of failure in rectal cancer patients today. Integrating more effective systemic therapy into combined modality programs is the challenge. The question that needs to be addressed is how and when to apply systemic treatment with adequate dose and intensity.
KW - Humans
KW - Randomized Controlled Trials as Topic
KW - dosage
KW - Combined Modality Therapy
KW - Disease Progression
KW - Clinical Trials, Phase II as Topic
KW - Antineoplastic Combined Chemotherapy Protocols therapeutic use
KW - Neoadjuvant Therapy
KW - Neoplasm Staging
KW - Chemotherapy, Adjuvant
KW - Feasibility Studies
KW - Radiotherapy, Adjuvant
KW - Fluorouracil administration
KW - Clinical Trials, Phase III as Topic
KW - Rectal Neoplasms drug therapy
KW - Rectum pathology
KW - Humans
KW - Randomized Controlled Trials as Topic
KW - dosage
KW - Combined Modality Therapy
KW - Disease Progression
KW - Clinical Trials, Phase II as Topic
KW - Antineoplastic Combined Chemotherapy Protocols therapeutic use
KW - Neoadjuvant Therapy
KW - Neoplasm Staging
KW - Chemotherapy, Adjuvant
KW - Feasibility Studies
KW - Radiotherapy, Adjuvant
KW - Fluorouracil administration
KW - Clinical Trials, Phase III as Topic
KW - Rectal Neoplasms drug therapy
KW - Rectum pathology
M3 - SCORING: Zeitschriftenaufsatz
VL - 186
SP - 658
EP - 664
JO - STRAHLENTHER ONKOL
JF - STRAHLENTHER ONKOL
SN - 0179-7158
IS - 12
M1 - 12
ER -
